Reliability of HES data; Internal reliability: Intra-class correlation coefficient for each comorbidity; external reliability: Proportion of agreement for the diagnosis of the index cancer between the diagnostic fields of HES and the cancer registration data, by cancer and year of diagnosis.

<p>Reliability of HES data; Internal reliability: Intra-class correlation coefficient for each comorbidity; external reliability: Proportion of agreement for the diagnosis of the index cancer between the diagnostic fields of HES and the cancer registration data, by cancer and year of diagnosis.</p

Numbers and proportions of patients with comorbidities detected at selected time points through the ten years preceding laryngeal cancer diagnosis made in 2013, given three restriction windows, N = 1,789.

<p>Numbers and proportions of patients with comorbidities detected at selected time points through the ten years preceding laryngeal cancer diagnosis made in 2013, given three restriction windows, N = 1,789.</p

Graphical representation of data management and time-related assumptions.

<p>Graphical representation of data management and time-related assumptions.</p

Hazard Ratios (HR) for the effects of cancer-related^* and non-cancer related^* comorbidities on the overall hazard of death, laryngeal cancer patients diagnosed in England in 2013, N = 1,789.

<p>Hazard Ratios (HR) for the effects of cancer-related^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172814#t004fn002" target="_blank">*</a>} and non-cancer related^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172814#t004fn002" target="_blank">*</a>} comorbidities on the overall hazard of death, laryngeal cancer patients diagnosed in England in 2013, N = 1,789.</p

Association of Body Mass Index with Hypertensive Disorders during Pregnancy Stratified by Smoking Status.

<p>Association of Body Mass Index with Hypertensive Disorders during Pregnancy Stratified by Smoking Status.</p

Demographic and Pregnancy Characteristics of Cases and Controls^*.

<p>Demographic and Pregnancy Characteristics of Cases and Controls<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152187#t001fn002" target="_blank">^*</a>.</p

Association of Body Mass Index with Hypertensive Disorders during Pregnancy.

<p>Association of Body Mass Index with Hypertensive Disorders during Pregnancy.</p

Patients characteristics at study entry and crude rates of progression to death/loss to follow-up and virologic rebound by club participation.

*<p>Restricted to patients who had virologic suppression at study entry, n = 2517.</p>**<p>Patients who went on to enrol in a club contributed analysis time to the “not in club” group until they were enrolled in the club. There is no single point in time where characteristics of patients who enrol in clubs and other patients can be formally compared due to the progressive nature of club enrolment. Instead predictors of club participation are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056088#pone-0056088-t002" target="_blank">Table 2</a>. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056088#pone-0056088-t001" target="_blank">Table 1</a> shows event rates since study entry to the outcome endpoint or censoring.</p><p>ART: Antiretroviral therapy; WHO: World Health Organization; CI: Confidence interval; IQR (inter-quartile range).</p

A directed acyclic graph representing the causal relationships between adherence club participation, outcomes, baseline and time-updated covariates.

<p>A directed acyclic graph representing the causal relationships between adherence club participation, outcomes, baseline and time-updated covariates.</p

Estimated effect of club participation from unweighted and weighted Cox models.

<p>Weighted model with baseline covariates estimates the parameters of a marginal structural model, adjusting for confounding due to measured time-dependent covariates.</p