40 research outputs found
Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer
BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) stabilizes oxyhaemoglobin, causing a reversible left-shift of the oxygen saturation curve (OSC) and tissue hypoxia. The activity of mitomycin C (MMC) is enhanced by hypoxia. In this phase II study, 17 patients with metastatic colorectal cancer resistant to 5-fluorouracil (5-FU) received BW12C and MMC. BW12C was given as a bolus loading dose of 45 mg kgâ1over 1 h, followed by a maintenance infusion of 4 mg kgâ1hâ1for 5 h. MMC 6 mg mâ2was administered over 15 min immediately after the BW12C bolus. The 15 evaluable patients had progressive disease after a median of 2 (range 1â4) cycles of chemotherapy. Haemoglobin electrophoresis 3 and 5 h after the BW12C bolus dose showed a fast moving band consistent with the BW12C-oxyhaemoglobin complex, accounting for approximately 50% of total haemoglobin. The predominant toxicities â nausea/vomiting and vein pain â were mild and did not exceed CTC grade 2. Liver31P magnetic resonance spectroscopy of patients with hepatic metastases showed no changes consistent with tissue hypoxia. The principle of combining a hypoxically activated drug with an agent that increases tissue hypoxia is clinically feasible, producing an effect equivalent to reducing tumour oxygen delivery by at least 50%. However, BW12C in combination with MMC for 5-FU-resistant colorectal cancer is not an effective regimen. This could be related to drug resistance rather than a failure to enhance cytotoxicity. © 2000 Cancer Research Campaig
Das persische Volk im Wandel : Studien zur Sozialgeschichte der Zeit von NÄáčŁiru'd-DÄ«n Ć Äh (1848 - 1896)
Heinz-Georg Migeo
Die persische Gesellschaft unter NÄáčŁiruÊŸd-DÄ«n Ć Äh : (1848 - 1896)
Zugl.: Göttingen, Univ., Diss., 1956Heinz-Georg Migeod. Mit einer Vorbemerkung von Bert G. FragnerOriginally presented as the author's thesis (doctoral)--UniversitÀt Göttinge
The Mende language, containing useful phrases, elementary grammar, short vocabularies, reading materials,
Mode of access: Internet