FlexHH: A flexible hardware library for Hodgkin-Huxley-based neural simulations

In the field of computational neuroscience, complex mathematical models are used to replicate brain behavior with the goal of understanding the biological processes involved. The simulation of such models are computationally expensive and therefore, in recent years, high-performance computing systems have been identified as a possible solution to accelerate their execution. However, most of those implementations are model-specific and thus non-reusable for other modeling efforts, requiring a completely new development effort per model used. The challenge lies in offering high-performance and scalable libraries (so as to support the construction and simulation of large-scale brain models) while at the same time offering high degrees of modeling flexibility and parameterization. This thesis presents flexHH, a scalable hardware library implementing five accelerated and highly parameterizable instances of the Hodgkin-Huxley neuron model, one of the most widely used biophysically-meaningful neuron representations. As a result, the user is able to instantiate custom models using flexHH and immediately take advantage of the acceleration without the mediation of the engineer. The five flexHH implementations target the Maxeler Data-Flow Engine(DFE), an FPGA-based acceleration solution, and incrementally support a number of features such as custom ion channels, multiple cell compartments and inter-neuron gap-junction connectivity. Furthermore, for each of the five implementations it is possible to select either the forward-Euler, second, or third-order Runge-Kutta numerical method. A speedup between 14x-36x has been achieved compared to a sequential C implementation, when run on a 2.5-GHz Intel Core-i7 CPU, while no practical performance drop is observed when compared to a hard-coded version of a DFE, an Intel Xeon-Phi CPU, and a NVidia Titan X GPU. In this thesis, flexHH kernels are rigorously validated, an evaluation of the influence of the numerical methods is done, and a comprehensive resources usage, performance, and power-consumption evaluation of the various DFE implementations is presented

FlexHH: A Flexible Hardware Library for Hodgkin-Huxley-Based Neural Simulations

The Hodgkin-Huxley (HH) neuron is one of the most biophysically-meaningful models used in computational neuroscience today. Ironically, the model's high experimental value is offset by its disproportional computational complexity. To such an extent that neuroscientists have either resorted to simpler models, losing precious neuron detail, or to using high-performance computing systems, to gain acceleration, for complex models. However, multicore/multinode CPU-based systems have proven too slow while FPGA-based ones have proven too time-consuming to (re)deploy to. Clearly, a solution that bridges user friendliness and high speedups is necessary. This paper presents flexHH, a flexible FPGA library implementing five popular, highly parameterizable variants of the HH neuron model. flexHH is the first crucial step towards making FPGA-based simulations of compute-intensive neural models available to neuroscientists without the debilitating penalty of re-engineering and re-synthesis. Through flexHH, the user can instantiate custom models and immediately take advantage of the acceleration without the mediation of an engineer, which has proven to be a major inhibitor to full adoption of FPGAs in neuroscience labs. In terms of performance, flexHH achieves speedups between 8 × - 20 × compared to sequential-C implementations, while only a small drop in real-time capabilities is observed when compared to hardcoded FPGA-based versions of the models tested. Computer EngineeringNumerical AnalysisBio-Electronic