20 research outputs found
The influence of endoscopic procedures upon the contamination of Helicobacter pylori cultures
Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer
Metronidazole resistance: A predictor of failure of Helicobacter pylori eradication by triple therapy
Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease
NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE-TYPE GASTRIC CANCER IN YOUNG PATIENTS
Metronidazole- and clarithromycin-resistant Helicobacter pylori in dyspeptic patients in western Sydney as determined by testing multiple isolates from different gastric sites
Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?
Modification of drug delivery to improve antibiotic targeting to the stomach
The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach