13 research outputs found

    Classification of nonoscillatory solutions of higher order neutral type difference equations

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    summary:The authors consider the difference equation Δm[ynpnynk]+δqnyσ(n+m1)=0() \Delta ^{m} [y_{n} - p_{n} y_{n - k}] + \delta q_{n} y_{\sigma (n + m - 1)} = 0 \qquad \mathrm {(\ast )} where m2m \ge 2, δ=±1\delta = \pm 1, kN0={0,1,2,}k \in N_0 = \lbrace 0,1, 2, \dots \rbrace , Δyn=yn+1yn\Delta y_{n} = y_{n + 1} - y_{n}, qn>0q_{n} > 0, and {σ(n)}\lbrace \sigma (n)\rbrace is a sequence of integers with σ(n)n\sigma (n) \le n and limnσ(n)=\lim _{n \rightarrow \infty } \sigma (n) = \infty . They obtain results on the classification of the set of nonoscillatory solutions of (\ast ) and use a fixed point method to show the existence of solutions having certain types of asymptotic behavior. Examples illustrating the results are included

    Involucrin modulates vitamin D receptor activity in the epidermis

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    Terminally differentiated keratinocytes are critical for epidermal function and are surrounded by involucrin (IVL). Increased IVL expression is associated with a near-selective sweep in European populations compared with those in Africa. This positive selection for increased IVL in the epidermis identifies human adaptation outside of Africa. The functional significance is unclear. We hypothesize that IVL modulates the environmentally sensitive vitamin D receptor (VDR) in the epidermis. We investigated VDR activity in Iv

    Classification of nonoscillatory solutions of higher order neutral type difference equations

    Get PDF
    summary:The authors consider the difference equation Δm[ynpnynk]+δqnyσ(n+m1)=0() \Delta ^{m} [y_{n} - p_{n} y_{n - k}] + \delta q_{n} y_{\sigma (n + m - 1)} = 0 \qquad \mathrm {(\ast )} where m2m \ge 2, δ=±1\delta = \pm 1, kN0={0,1,2,}k \in N_0 = \lbrace 0,1, 2, \dots \rbrace , Δyn=yn+1yn\Delta y_{n} = y_{n + 1} - y_{n}, qn>0q_{n} > 0, and {σ(n)}\lbrace \sigma (n)\rbrace is a sequence of integers with σ(n)n\sigma (n) \le n and limnσ(n)=\lim _{n \rightarrow \infty } \sigma (n) = \infty . They obtain results on the classification of the set of nonoscillatory solutions of (\ast ) and use a fixed point method to show the existence of solutions having certain types of asymptotic behavior. Examples illustrating the results are included

    Involucrin modulates vitamin D receptor activity in the epidermis

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    Terminally differentiated keratinocytes are critical for epidermal function and surrounded by involucrin (IVL). Increased IVL expression is associated with a near selective sweep in European populations compared to African. This positive selection for increased IVL in the epidermis identifies human adaptation out-of-Africa. The functional significance is unclear. We hypothesize Ivl to modulate the environmentally sensitive Vitamin D receptor (Vdr) in the epidermis. We investigated Vdr activity in Ivl -/- and wild-type (WT) mice using vitamin D agonist (MC903) treatment and comprehensively determined the inflammatory response using single-cell RNA sequencing (scRNA-seq) and associated skin microbiome changes using 16S bacterial phylotyping. Vdr activity and target gene expression were reduced in Ivl -/- mouse skin, with decreased MC903-mediated skin inflammation and significant reductions in CD4+ T cells, basophils, macrophages, monocytes, and type II basal keratinocytes and increase in suprabasal keratinocytes. Coinciding with the dampened MC903-mediated inflammation, skin microbiota of Ivl -/- mice was more stable compared to WT mice, which exhibited a MC903-responsive increase in Bacteroidetes and decrease in Firmicutes. Together, our studies in Ivl -/- mice identify a functional role for Involucrin to positively impact Vdr activity and suggest an emerging IVL/VDR paradigm for adaptation in the human epidermis

    Development and design of automated hospital bed with incremental panels for bedsore prevention

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    The common causes of Bedsores are constant pressure and moisture build-up. To prevent the development of these causes, the researchers have decided to modify the typical hospital bed into an electronically automated prototype. The prototype was built with 50 incremental panels that has the capability to move the patient on the by the combination of the Chain and Sprocket Method and the Lead Screw. These incremental panels were implemented with Temperature Sensors to monitor the ambient temperature on the bed surface and IR Proximity sensors to detect the location of the patient in the prototype. The data gathered by these sensors are processed through the use of a microcontroller. The microcontroller will then relay the processed data to the stepper motor driver which will manipulate the stepper motors to cause movement to the incremental panels. © 2014 IEEE

    Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

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    ©2019American Society for Bone andMineral Research. Osteoporosis-related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to develop clinical recommendations for the optimal prevention of secondary fractureamong people aged 65 years and older with a hip or vertebral fracture. The coalition developed 13 recommendations (7 primary and 6 secondary) strongly supported by the empirical literature. The coalition recommends increased communication with patients regarding fracture risk, mortality and morbidity outcomes, and fracture risk reduction. Risk assessment (including fall history) should occur at regular intervals with referral to physical and/or occupational therapy as appropriate. Oral, intravenous, andsubcutaneous pharmacotherapies are efficaciousandcanreduce risk of future fracture.Patientsneededucation,however, about thebenefitsandrisks of both treatment and not receiving treatment. Oral bisphosphonates alendronate and risedronate are first-line options and are generally well tolerated; otherwise, intravenous zoledronic acid and subcutaneous denosumab can be considered. Anabolic agents are expensive butmay be beneficial for selected patients at high risk.Optimal duration of pharmacotherapy is unknown but because the risk for second fractures is highest in the earlypost-fractureperiod,prompt treatment is recommended.Adequate dietary or supplemental vitaminDand calciumintake shouldbe assured. Individuals beingtreatedfor osteoporosis shouldbe reevaluated for fracture risk routinely, includingvia patienteducationabout osteoporosisandfracturesandmonitoringfor adverse treatment effects.Patients shouldbestronglyencouraged to avoid tobacco, consume alcohol inmoderation atmost, and engage in regular exercise and fall prevention strategies. Finally, referral to endocrinologists or other osteoporosis specialists may be warranted for individuals who experience repeated fracture or bone loss and those with complicating comorbidities (eg, hyperparathyroidism, chronic kidney disease)
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