Talarazines A–E: Noncytotoxic Iron(III) Chelators from an Australian Mud Dauber Wasp-Associated Fungus, <i>Talaromyces</i> sp. (CMB-W045)

Chemical analysis of an Australian mud dauber wasp-associated fungus, <i>Talaromyces</i> sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A–E (<b>1</b>–<b>5</b>), together with dimerumic acid (<b>6</b>), desferricoprogen (<b>7</b>), and elutherazine B (<b>8</b>). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C₃ Marfey’s method. We report on the noncytotoxic Fe­(III) chelation properties of <b>1</b>–<b>8</b> and demonstrate that biosynthesis is regulated by available Fe­(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe­(III) binding metabolites (i.e., <b>8</b>) from complex extracts

Afurika nanbu ni okeru gengo no kiki - Matthias Brenzinger-shi ni kiku [Language Endangerment ion Southern Africa - Interview with Matthias Brenzinger]

Viridicatumtoxins, which belong to a rare class of fungal tetracycline-like mycotoxins, were subjected to comprehensive spectroscopic and chemical analysis, leading to reassignment/assignment of absolute configurations and characterization of a remarkably acid-stable antibiotic scaffold. Structure activity relationship studies revealed exceptional growth inhibitory activity against vancomycin-resistant Enterococci (IC₅₀ 40 nM), >270-fold more potent than the commercial antibiotic oxytetracycline

Waspergillamide A, a Nitro <i>depsi</i>-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated <i>Aspergillus</i> sp. (CMB-W031)

Chemical profiling of extracts from a mud dauber wasp-associated fungus, <i>Aspergillus</i> sp. (CMB-W031), revealed a remarkably diverse array of secondary metabolites, with many biosynthetic gene clusters being transcriptionally responsive to specific culture conditions. Chemical fractionation of a jasmine rice cultivation yielded many known fungal metabolites, including the highly cytotoxic (−)-stephacidin B and an unprecedented nonribosomal peptide synthase derived nitro <i>depsi</i>-tetrapeptide diketopiperazine, waspergillamide A (<b>1</b>). All structures were assigned by detailed spectroscopic analysis and, where appropriate, chemical degradation and Marfey’s analysis

Rare <i>Streptomyces N</i>-Formyl Amino-salicylamides Inhibit Oncogenic K‑Ras

During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of <i>Streptomyces orinoci</i>, and reassigned/assigned structures to all based on detailed spectroscopic analysis and microscale C₃ Marfey’s and C₃ Mosher chemical degradation/derivatization/analysis. SAR investigations inclusive of the biosynthetically related antimycins and respirantin, and synthetic benzoxazolone, documented a unique <i>N</i>-formyl amino-salicylamide pharmacophore as a potent inhibitor of oncogenic K-Ras

Photographs of study species displaying conspicuous colour patterns.

<p>Photographs of study species displaying conspicuous colour patterns.</p

Anti-feedant assay.

<p>rejection of pellets (%) by palaemon shrimp, <i>Palaemon serenus</i>.</p

Structures of compounds identified.

<p>latrunculin A (<b>1</b>), puupehenone (<b>2</b>), deoxymanoalide (<b>3</b>) and deoxysecomanoalide (<b>4</b>), pallescensone (<b>5</b>), dendrillolide A (<b>6</b>), aplyviolene (<b>7</b>) and aplysulphurin (<b>8</b>).</p

Cytotoxic activities.

<p>against SW620, NCHI420 and KN3-1 cancer cell lines.</p