Frontal fibrosing alopecia development in two patients after botulinum toxin applications: relationship or coincidence?

Frontal fibrous alopecia is a primary lymphocytic scarring alopecia that is difficult to control, with a perifollicular lichenoid infiltrate marking its histology. Since its description in 1994 by Kossard, there has been an increase in cases reported worldwide. This article reports two cases that underwent incisional biopsies with longitudinal and transverse sections in areas presenting higher disease activity and reviews some aspects of this dermatosis. It also addresses the suspicion of a possible relationship with the application of botulinum toxin – a question already raised by other authors but with no established confirmation

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change

Made available in DSpace on 2019-09-11T20:58:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2019Abstract: Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Cutaneous metastases from follicular carcinoma are rare and occur mainly in the head and neck area. We report a case of cutaneous metastasis in a patient with follicular thyroid carcinoma and breast carcinoma. Because of the association of these two neoplasms, the possibility of Cowden Syndrome - multiple hamartoma syndrome - was raised, but was excluded by genetic analysis of PTEN gene.[Rocha, Jeanine Alvarenga] Laboratório Bacchi, BrazilLira, Marcia Lanzoni Alvarenga] Laboratório do Vale, BrazilAlmeida, Mariana Abdo de] Universidade de Taubaté, BrazilReis-Feroldi, Michele Maria] Private practice, Brazi