Infusão contínua de remifentanil em paciente cardiopata para correção de hérnia perianal

O remifentanil é um analgésico opioide µ de ação muito curta.  Na medicina humana, o remifentanil tem sido amplamente utilizado para sedação e anestesia de pacientes com condições cardíacas críticas. Em cães estudos anteriores demonstraram que o remifentanil diminui significativamente o índice cardíaco acompanhado de bradicardia em cães anestesiados com anestésicos inalatórios. Assim, temos uma melhora da recuperação anestésica e estabilidade cardiovascular quando administrado por infusão contínua. Este relato tem como objetivo mostrar os efeitos da infusão contínua de remifentanil em paciente cardiopata atendido em uma clínica veterinária particular submetido a cirurgia para correção de hérnia perineal. Durante a realização do procedimento o animal apresentou pouca resposta ao estímulo de dor durante a anestesia. Todavia, apresentou bradicardia e hipotensão, que foram responsivas a atropina e noradrenalina, mantendo o animal com a pressão e frequência cardíacas adequadas durante todo o procedimento. Conclui-se que a utilização de remifentanil em doses baixas em paciente cardiopata funciona como um adjuvante no controle da dor permitindo ao paciente uma rápida recuperação após o procedimento

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

EBV-encoded microRNAs (miRNAs) have been identified and their functions are being studied. The expression pattern of these miRNAs in clinical samples of EBV-associated non–Hodgkin’s lymphomas is unknown. We analyzed five primary “endemic” pediatric Burkitt’s lymphomas (BL), two acquired immunodeficiency syndrome (AIDS)-related type I latency BL lines, a type III latency line, three EBV+ primary effusion lymphomas (PEL), and three AIDS-related diffuse large B-cell lymphomas (DLBCL) for expression of EBV-encoded miRNAs. A markedly elevated expression of miRNA BHRF1-3 in type III relative to its parental type I BL line was found. Primary unmanipulated type I BLs and EBV+ PELs expressed high levels of BART2 miRNA, whereas DLBCLs expressed both BART2 and BHRF1-3 species. BHRF1-3 miRNA expression inversely correlated with levels of a putative cellular target, the IFN-inducible T-cell attracting chemokine CXCL-11/I-TAC, and suppression of this factor was reversed by transfection of an antisense oligo to the EBV miRNA BHRF1-3. EBV-encoded miRNAs are expressed in primary lymphomas classically linked to the virus and are associated with the viral latency status. Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors

Ticks infesting wild small rodents in three areas of the state of São Paulo, Brazil Carrapatos infestando pequenos roedores silvestres em três municípios do estado de São Paulo, Brasil

ABSTRACT From May to September 2011, a total of 138 wild rodents of the Cricetidae family were collected in the cities o

Occurrence of eggs and oocysts of gastrointestinal parasites in passerine birds kept in captivity in Para State, Brazil Ocorrência de ovos e oocistos de parasitos gastrointestinais em aves Passeriformes mantidas em cativeiro no estado do Pará, Brasil

ABSTRACT The objective of this study was to detect helminth eggs and protozoan oocysts in samples of feces from birds of the orde

Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease

Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD). Objective To describe the association between codon 129 polymorphisms and AD. Methods We investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated. Results Codon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups. Conclusion Codon 129 polymorphism is not a risk factor for AD in Brazilian patients