Preprocessing by <i>OR</i>.

<p>Rows represent the three classes fusiform, epithelioid and cobblestone. <i>Left</i>: original image; <i>right</i>: the three oriented images.</p

Texture descriptors and their parameter sets.

<p>Texture descriptors and their parameter sets.</p

Performance (<i>AUC</i>) comparison among different <i>Bsif</i>-based approaches.

<p>Performance (<i>AUC</i>) comparison among different <i>Bsif</i>-based approaches.</p

Comparison of <i>Full_Bsif</i> and the ensemble <i>F</i> of the best methods investigate in this section (<i>AUC</i> is reported).

<p>Comparison of <i>Full_Bsif</i> and the ensemble <i>F</i> of the best methods investigate in this section (<i>AUC</i> is reported).</p

Preprocessing by <i>Wa</i>.

<p>Rows represent the three classes fusiform, epithelioid and cobblestone. <i>Left</i>: original image; <i>right</i>: horizontal, vertical and diagonal details.</p

Class properties used for building the ground truth.

<p>Class properties used for building the ground truth.</p

Preprocessing by Gabor filters.

<p>Rows represent the three classes fusiform, epithelioid and cobblestone. <i>Left</i>: original image; <i>right</i>: convolved images at scale 4.</p

Preprocessing approaches.

<p>Preprocessing approaches.</p

<i>Loci</i> of points defining the different neighborhood topologies.

<p>For each geometric <i>locus</i> defined in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149399#pone.0149399.ref012" target="_blank">12</a>], its formal definition and parameters are reported.</p

Constant parameters and initial conditions.

<p>Most of the parameters were taken from the models of Lemon et al. 2003[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128434#pone.0128434.ref021" target="_blank">21</a>] for P₂Y₂ receptor, LeBeau et al. 1999[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128434#pone.0128434.ref022" target="_blank">22</a>] for IP₃R₃, and Keizer & Levine 1996[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128434#pone.0128434.ref023" target="_blank">23</a>] for RyR. Reference ‘fitted’ means that the parameter was optimized in this study.</p><p>Constant parameters and initial conditions.</p