315 research outputs found
La maladie de Chagas en Bolivie : données préliminaires sur les cycles domestiques : méthodes simplifiées de captures des triatomes
Antigenic diversity and the transmission dynamics of Plasmodium falciparum : the clonality/sexuality debate revisited
Considérations sur les propriétés immunologiques des enzymes de parasites (en particulier Trypanosoma cruzi) et sur leurs applications possibles
Note préliminaire sur les isoenzymes de Triatoma infestans (Hemiptera, Reduviidae), vecteur majeur de la maladie de Chagas en Amérique latine
Reproductive clonality of pathogens : a perspective on pathogenic viruses, bacteria, fungi, and parasitic protozoa
We propose that clonal evolution in micropathogens be defined as restrained recombination on an evolutionary scale, with genetic exchange scarce enough to not break the prevalent pattern of clonal population structure, a definition already widely used for all kinds of pathogens, although not clearly formulated by many scientists and rejected by others. The two main manifestations of clonal evolution are strong linkage disequilibrium (LD) and widespread genetic clustering ("near-clading"). We hypothesize that this pattern is not mainly due to natural selection, but originates chiefly from in-built genetic properties of pathogens, which could be ancestral and could function as alternative allelic systems to recombination genes ("clonality/sexuality machinery") to escape recombinational load. The clonal framework of species of pathogens should be ascertained before any analysis of biomedical phenotypes (phylogenetic character mapping). In our opinion, this model provides a conceptual framework for the population genetics of any micropathogen
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Isozyme variability in Trypanosoma cruzi, the agent of Chagas' disease : genetical, taxonomical, and epidemiological significance
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