5 research outputs found

    Specific IgG1 production and inhibition of enzymatic activity of rSh28GST by sera of vaccinated volunteers.

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    <p>Adult human volunteers received three administrations of rSh28GST of 100 ”g respectively at D0, D28 and D150. IgG1 production is expressed as mean +/− SEM of titers at each time. Titer was defined as the highest dilution yielding an absorbance three times above background. Enzymatic inhibition is expressed in % (histograms). Percentage of inhibition was calculated by the ratio GST activity after serum incubation to GST activity control. This value was considered significantly positive above 10%.</p

    Anti-Sh28GST antibody levels in healthy adult volunteers after administration of rSh28GST 100 ”g.

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    a<p>Specific Ig antibody levels are expressed as the mean of individual titer (± SEM). Number of responders after vaccination is indicated in parentheses.</p>b<p>Day of Sh28GST administration (D<sub>0</sub>; D<sub>28</sub>; D<sub>150</sub>).</p>*<p>Significantly different (P<0.05) compared to D<sub>0</sub> (comparison of mean using the Wilcoxon test).</p>**<p>Significantly different (P<0.05) compared to D<sub>150</sub> (comparison of mean using the Wilcoxon test).</p

    Anti-Sh28GST antibody levels in healthy adult volunteers after administration of Alum (comparator group).

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    a<p>Specific Ig antibody levels are expressed as the mean of individual titer (± SEM). Number of responders after vaccination is indicated in parentheses.</p>b<p>Day of comparator administration (D<sub>0</sub>; D<sub>28</sub>; D<sub>150</sub>).</p

    Main baseline laboratory results.

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    <p>Abbreviations: WBC, white blood cell count; PTT, partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase. Data are presented as mean ± standard deviation.</p>*<p>Local laboratory values. All other biological tests were in normal ranges.</p
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