Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy-3

<p><b>Copyright information:</b></p><p>Taken from "Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy"</p><p>http://www.biomedcentral.com/1471-2415/7/13</p><p>BMC Ophthalmology 2007;7():13-13.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2040130.</p><p></p>ucted comparing PC vs no PC in eyes operated on before 7 months only. The survival plot is supportive of the statement that intact PCs may be associated with lower risk of AG. The observed difference is not statistically significant but this is not surprising given that only 3 patients operated on within 7 months had their PC intact

Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy-0

<p><b>Copyright information:</b></p><p>Taken from "Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy"</p><p>http://www.biomedcentral.com/1471-2415/7/13</p><p>BMC Ophthalmology 2007;7():13-13.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2040130.</p><p></p>rate of AG was higher in eyes operated on within 4 weeks. The log rank test revealed strong evidence of an association between timing of surgery and rate of AG (P = 0.028)

Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy-2

<p><b>Copyright information:</b></p><p>Taken from "Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy"</p><p>http://www.biomedcentral.com/1471-2415/7/13</p><p>BMC Ophthalmology 2007;7():13-13.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2040130.</p><p></p>ucted comparing PC vs no PC in eyes operated on after 4 weeks only. Log rank tests revealed that these differences persisted (P = 0.048)

Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy-1

<p><b>Copyright information:</b></p><p>Taken from "Glaucoma following congenital cataract surgery – the role of early surgery and posterior capsulotomy"</p><p>http://www.biomedcentral.com/1471-2415/7/13</p><p>BMC Ophthalmology 2007;7():13-13.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2040130.</p><p></p>

Additional file 1: of Investigation of SLA4A3 as a candidate gene for human retinal disease

Molecularly unsolved patients with autozygosity data indicating a homozygous region containing SLC4A3. In eight of the individuals studied, previous autozygosity mapping had identified loci associated with retinal disease. Here we list the sizes of the loci and the number of genes in each. (PDF 16 kb

The baseline, 12 and 24 months best corrected visual acuity and central macular thickness broken down by categories.

<p>ETDRS –early treatment diabetic retinopathy study; CMT- central retinal macular thickness.</p

Visual acuity and anatomical outcome measures at 24 months compared to baseline.

<p><b>BOLD = significant p<0.05</b> VA-visual acuity; SD- standard deviation; CMT –central macular thickness.</p

Outcomes measures in terms of visual acuity and anatomical changes at 12 months from baseline.

<p>BOLD = significant p<0.05;</p>$<p>1 missing value; VA-visual acuity; SD- standard deviation; CMT –central macular thickness.</p

The evolution patterns of diabetic macular oedema at 12 and 24 months.

<p>The evolution patterns of diabetic macular oedema at 12 and 24 months.</p

Generation of <i>Guca1a</i>^COD3 ‘knock-in’ mice with E155G mutation in GCAP1.

<p>(<b>a</b>) A vector targeting the endogenous <i>Guca1a</i> locus was constructed to include an A-to-G transversion at nucleotide position 19 in exon 4 of <i>Guca1a</i> (red circle), as well as a <i>loxP</i>-flanked (blue arrow heads) neomycin resistance gene within intron 3. Following <i>Cre</i>-mediated excision of the <i>Neo</i> selectable marker, the resulting locus contained the A-to-G change in exon 4 plus a residual 34 bp <i>loxP</i> sequence in intron 3. This was used to distinguish between mutant and native alleles by PCR – the position of the primers used is indicated by the small blue arrows on the <i>Cre</i>-deleted <i>Guca1a</i> locus. (<b>b</b>) PCR amplicons from wild-type, <i>Guca1a</i>^+/COD3 and <i>Guca1a</i>^COD3/COD3 mice (lanes 3, 4 and 5 respectively), with 1 kb DNA ladder (lane 1) and no-DNA control (lane 2). The wild type allele generates a band at 734 bp whereas the mutant allele generates a 768 bp band which includes the residual intronic <i>loxP</i> sequence. Wild-type mice have therefore a single band at 734 bp, homozygous <i>Guca1a</i>^COD3/COD3 mice have a single band at 768 bp, and heterozygous <i>Guca1a</i>^+/COD3 mice have both bands. (<b>c</b>) Sequence of wild type and targeted <i>Guca1a</i> allele showing A-to-G transversion at nucleotide position 19 of exon 4.</p