Model-adjusted mean difference in ABPM for rosiglitazone compared to sulfonylurea and to metformin in combination therapy

Model-adjusted mean difference in ABPM for rosiglitazone compared to sulfonylurea and to metformin in combination therapy. <p> </p> <p><b>Copyright information:</b></p><p>Taken from "Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: A randomized controlled trial (the RECORD study)"</p><p>Cardiovascular Diabetology 2008;7():10-10.</p><p>Published online 24 Apr 2008</p><p>PMCID:PMC2390513.</p><p></p

Representative immunolocalization of intercalated disc proteins in ARVD/C patient right ventricles.

<p>Representative pictures of plakophilin-2, β-catenin, plakoglobin, desmoglein-2 and desmocollin-2 labeling are shown (in green). Cardiac myosin-binding protein C (cMyBP-C) and α-actinin-2 (both red labeling) were used as cardiomyocyte specific markers. The figure shows heart tissue from two patients with ARVD/C compared to a representative (non ARVD/C) control.</p

Quantitative immunoblotting of selected intercalated disk proteins; plakophilin-2, plakoglobin and β-catenin.

<p>Representative immunoblots obtained for (a) plakoglobin (left Ventricle), (b) β-catenin (septum) and (c) plakophilin-2 (septum). Bar graphs indicate the mean ± SEM following quantification of protein signals from all blots from the seven patient tissue samples and all compartments after normalization to the cardiac protein α-actinin-2 (ACTN2) or cardiac myosin-binding protein C (cMyBP-C) and to the control with the strongest signal level. NS for <i>p</i>>0.05, Mann Whitney test.</p

Quantitative RT-PCR analysis of <i>DSG2</i> and <i>DSC2</i> relative to <i>ACTN2</i> mRNA transcripts.

<p>Relative quantification was performed using RNA isolated from the septum or right ventricle of heart samples. Bar graphs show the mean ± SEM of six samples (2^-ΔΔCT method). <i>p</i>>0.05, Mann Whitney Test.</p

Electron microscopy of heart samples from ARVD/C 6.

<p>The electronic microscopy study of heart tissue from the p.Arg46Trp mutation-carrier (ARVD/C6) showed the presence of small desmosomes (white arrows) associated with abnormal inter-membrane vacuoles (black stars) in both ventricles (LV; left ventricle, RV; right ventricles).</p

Gene-level association analysis of genes identified in the SNP-level analysis

<p>Gene-level association analysis of genes identified in the SNP-level analysis</p

Forest Plots of odd-ratios (log) in the different populations.

<p>The results show that the associations were largely homogeneous across populations (See also heterogeneity column in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172995#pone.0172995.t002" target="_blank">Table 2</a>)</p

Manhattan Plot of association P-values.

<p>95,499 variants were investigated for association with DCM by logistic regression analysis. Associations are summarized in a Manhattan plot (R/qqman package) which displays the eleven SNVs significantly associated with DCM (Q-values < 0.01) as green dots. Note that the applied logistic model assumed an additive mode of inheritance. For variants on chromosome 15 in the <i>ALPK3</i> region, a dominant mode of inheritance was better supported by the data (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172995#pone.0172995.t001" target="_blank">Table 1</a> for corresponding P-values)</p

Variants associated with DCM.

<p>Variants associated with DCM.</p

DCM gene set association analysis

<p>DCM gene set association analysis</p