Circumstances in which OIB Occurred and their Concurrent Behaviors according to the Parental Evaluation in Individuals with Autism (N = 74).

<p><i>Note:</i> Data are frequency of patients (% of group) for each circumstance of occurrence and concurrent behavior.</p

Circumstances in which OIB occurred and their Concurrent Behaviors according to the Caregiver Evaluation in Individuals with Autism (N = 74).

<p><i>Note:</i> Data are frequency of patients (% of group) for each circumstance of occurrence and concurrent behavior.</p

Caregiver and Parental Evaluations of different Types of Other-Injurious Behavior (OIB) and Spearman Correlations between Caregiver and Parental Evaluations of OIB in individuals with Autism (n = 74).

<p><i>Note:</i> Data are frequency of patients (% of group) for each type of others-injurious behavior.</p><p>A same patient can present different types of other-injurious behavior. Spearman correlations were calculated on the quantitative scores of OIB provided by the OIB scale.</p

Brain β-Endorphin and plasma Testosterone concentrations (Mean ± SEM) in 11 inbred mouse strains (<i>n</i> = 5).

<p><i>Note:</i> Comparisons between the 11 strains for β-Endorphin and Testosterone concentrations were performed using ANOVA with F values indicated in the table; <i>n</i> = 5 animals for each strain, except for NBZ/BINj (<i>n</i> = 6); <i>SEM</i> = standard error of the mean.</p

Brain BE concentration (mean ±SEM) in NZB and CBA/H and their consomic strains for <i>Y^NPAR</i>.

<p>The N.H-<i>Y^NPAR</i> differs only from the NZB by the <i>Y^NPAR</i> from CBA/H, and the H.N- <i>Y^NPAR</i> differs only from the CBA/H by the <i>Y^NPAR</i> from NZB. Partial comparisons with Student's t test showed that the parental NZB and CBA/H strains differed significantly (<i>P</i><0.05), and each parental strain differed significantly from its consomic strain (CBA/H <i>vs.</i>H.N-<i>Y^NPAR</i>: <i>P</i><0.001; NZB <i>vs.</i> N.H-<i>Y^NPAR</i>: <i>P</i><0.01); <i>n</i> = 5 animals for each strain, except for NZB (<i>n</i> = 6); <i>SEM</i> = standard error of the mean.</p

Plasma testosterone concentration (mean ±SEM) in NZB and CBA/H and their consomic strains for <i>Y^NPAR</i>.

<p>The N.H-<i>Y^NPAR</i> differs only from the NZB by the <i>Y^NPAR</i> from CBA/H, and the H.N-<i>Y^NPAR</i> differs only from the CBA/H by the <i>Y^NPAR</i> from NZB. Partial comparisons with Student's t test showed that the parental NZB and CBA/H strains differed significantly (<i>P</i><0.0001), and the parental NZB strain differed significantly from its consomic strain (NZB <i>vs.</i> N.H-<i>Y^NPAR</i>: <i>P</i><0.001); <i>n</i> = 10 animals for each strain; <i>SEM</i> = standard error of the mean.</p

Evolution of the autistic behavioral domains (social interaction, communication and stereotypies) and subdomains based on the ADI-R algorithm for the 4–5 years old period, and on the ADI-R algorithm completed by the ADOS algorithm for the current period.

<p>Evolution of the autistic behavioral domains (social interaction, communication and stereotypies) and subdomains based on the ADI-R algorithm for the 4–5 years old period, and on the ADI-R algorithm completed by the ADOS algorithm for the current period.</p

Demographics, autistic behavioral domains and main physical features of the patients.

*<p>According to the ADI-R (Autism Diagnostic Interview-Revised) or the ADOS (Autism Diagnostic Observation Schedule) algorithm, the DSM-IV and the ICD-10 diagnostic criteria for autistic disorder are fulfilled when the total scores of each domain reach the cut-off.</p>**<p>YES: Limited expressive language and severe delay.</p>***<p>NL: normal; PS: pulmonary stenosis; S for SVAS: supravalvular aortic stenosis. Patient 6 had also a ventricular septal defect, an aortic coartation, a patent ductors arteriosus and a mitral insufficiency. Patient 7 had also a mitral stenosis and a tricuspid endocarditis with valvular involvment.</p>****<p>NL: normal; TRI: terminal renal insufficiency.</p

Overall Behavioral Pain Reactivity in Autism According to Rater/Setting.

<p>Types/classes of pain reactivity are described in detail in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005289#pone-0005289-t003" target="_blank">Table 3</a> and the numerical data are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005289#pone-0005289-t004" target="_blank">Table 4</a>.</p

Types of Pain Reactivity assessed by the PL-BPRS (Pre-Linguistic Behavioral Pain Reactivity Scale).

<p>Types of Pain Reactivity assessed by the PL-BPRS (Pre-Linguistic Behavioral Pain Reactivity Scale).</p