Characteristics of asthma patients with and without obstructive sleep apnoea (OSA).

<p>Characteristics of asthma patients with and without obstructive sleep apnoea (OSA).</p

Characteristics of OSA for OSA and non-OSA patients.

<p>Characteristics of OSA for OSA and non-OSA patients.</p

Airway inflammation variables in induced sputum from OSA and non-OSA patients.

<p>Airway inflammation variables in induced sputum from OSA and non-OSA patients.</p

Correlation between reticular basement membrane (RBM) thickness and apnoea-hypopnoea index (AHI).

<p>Correlation between reticular basement membrane (RBM) thickness and apnoea-hypopnoea index (AHI).</p

Flow of participants through the study.

<p>FOB: fibre optic bronchoscopy.</p

Airway remodelling and inflammation features in bronchial biopsies.

<p>Airway remodelling and inflammation features in bronchial biopsies.</p

Changes in the serum levels of the significantly-regulated proteins between COPD patients from Cluster 1 and Cluster 2.

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COPD Clusters are observed in an independent patient cohort, but not in healthy controls.

(A) Heatmap showing levels of differentially expressed proteins in the MLCC cohort. Yellow indicates high expression and cyan indicates low expression. (B) Overlap of the Cluster 2-associated up-regulated proteins (Fold change >1.5 for Cluster 2 vs Cluster 1 and FDR <0.05) between COBRA and MLCC cohorts. (C) Protein score (defined in CORBA cohort) in Cluster 1- and 2 in the MLCC cohort.</p

Methods and supplementary tables.

(PDF)</p

Characteristics of COPD patients of the COBRA cohort.

(PDF)</p