4 research outputs found
Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77–1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63–2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29–4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AM
Association of the 894G > T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
Background: This study was designed to investigate the association of
the 894G>T polymorphism in the eNOS gene with risk of acute myocardial
infarction ( AMI), extent of coronary artery disease ( CAD) on coronary
angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the
GEMIG study. The control group was comprised by 727 individuals, who
were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to
be significantly and independently associated with risk of AMI ( RR =
1.08, 95% CI = 0.77-1.51, P = 0.663), extent of CAD on angiography ( OR
= 1.18, 95% CI = 0.63-2.23, P = 0.605) and in-hospital mortality ( RR =
1.08, 95% CI = 0.29-4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298
variant of the 894G>T polymorphism in the eNOS gene was not found to be
associated with risk of AMI, extent of CAD and in-hospital mortality
after AMI