Stress and nausea during the experiment.

<p>Comparison of KAB stress symptom and nausea scores between participants with and without motion sickness during the parabolic flight experiment.</p><p>*p<0.01 and</p>#<p>p<0.005 when compared to participants without motion sickness. Data are mean±SD.</p>a<p>German Kurzfragebogen zur aktuellen Beanspruchung (short questionnaire of current stress; KAB) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010752#pone.0010752-Mueller1" target="_blank">[21]</a>.</p>b<p>Nausea was quantified on a verbal rating scale ranging from 1 =  no nausea to 6 =  maximal nausea.</p

MOESM1 of Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism

Additional file 1: Table S1. Baseline characteristics of the control study population. Table S2. Kinetic of plasma parameter and infusion rate of the surgical study population over time

Comparison of leukocyte cannabinoid receptor mRNA between volunteers with and without motion sickness during the parabolic flight experiment.

<p>RNA was prepared from whole blood and subjected to quantitative RT-PCR (triplicate determinations). Data were calculated relative to GAPDH and RPL13A-mRNA using an efficiency-corrected algorithm. *indicates a significant decline in CB1-receptor mRNA (W = −26.0, T+ = 1.0, T- = −27.0, p = 0.03, Wilcoxon Signed Rank Test) in volunteers with motion sickness when compared to 24 h pre-flight values. CB1-receptor mRNA in individuals without motion sickness remained unchanged over time (W = −8.0, T+ = 10.0, T- = −18.0, p = 0.58) as was CB2-receptor expression before and after the experiment. Horizontal black bars in the boxplots indicate median values; upper and lower lines of the boxes show the 5^th and 95^th percentile.</p

Whole blood endocannabinoid concentrations during a parabolic flight experiment in 21 male volunteers.

<p><i>Panel A</i> compares blood concentrations of the endocannabinoid anandamide between volunteers who developed motion sickness accompanied by severe N&V (n = 7, red lines) and those who did not (n = 14, blue lines). After the 10^th parabolic maneuver (T1), anandamide blood concentrations dropped in individuals with motion sickness but increased in volunteers without (Mann-Whitney U Statistic  = 14.5, T = 42.5, *p = 0.02). After the 20^th maneuver (T2), this difference remained significant (Mann-Whitney U Statistic  = 14.0, T = 42.0, *p = 0.01). <i>Panel B</i> shows the same comparison with regard to the endocannabinoid 2-AG. 2-AG values in volunteers with motion sickness remained almost constant and non-reactive but increased in individuals without. *indicates significantly higher 2-AG blood concentrations in individuals without motion sickness after termination of parabolic maneuvers (Mann-Whitney U Statistic = 0.0, T = 85.0, p = 0.04).</p

Additional file 3: of Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

PK/PD target attainment.pdf. (PDF 65 kb

Effect of comorbid depression or the use of antidepressants on plasma EC/NAE concentrations.

<p>Effect of comorbid depression or the use of antidepressants on plasma EC/NAE concentrations.</p

Correlation between the number of CAPS traumatic event types and OLDA plasma concentrations (r = −0.50, p = 0.03, n = 19).

<p>The solid line represents the regression line and dotted lines 95% confidence intervals.</p

Relationship between OLDA plasma concentrations and CAPS scores.

<p>Panel A: CAPS sum score (r = −0.68, p<0.01, n = 19); Panel B: CAPS – intrusion subscore (r = −0.65, p<0.01); Panel C: CAPS – avoidance subscore (r = −0.59, p<0.01); Panel D: CAPS – hyperarousal subscore (r = −0.66, p<0.01). Solid line indicates regression line and dotted lines 95% confidence intervals.</p

EC/NAE concentrations in smokers vs. non-smokers.

<p>EC/NAE concentrations in smokers vs. non-smokers.</p

Correlation between CAPS scores and PEA plasma levels in individuals after trauma exposure (n = 19).

<p>Panel A: CAPS sum score (r = 0.54, p = 0.02); Panel B: CAPS – intrusion subscore (r = 0.65, p<0.01); Panel C: CAPS – avoidance subscore (r = 0.21, p = 0.40); Panel D: CAPS - hyperarousal subscore (r = 0.29, p = 0.23). Solid line indicates regression line and dotted lines 95% confidence intervals.*marks significant correlations.</p