3 research outputs found
Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis
Detailed in this
Communication is the enantioselective synthesis of 1,1-diarylalkanes,
a structure found in a range of pharmaceutical drug agents and natural
products, through the employment of copper(I) hydride and palladium
catalysis. Judicious choice of ligand for both Cu and Pd enabled this
hydroarylation protocol to work for an extensive array of aryl bromides
and styrenes, including β-substituted vinylarenes and six-membered
heterocycles, under relatively mild conditions
Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles
We
report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation
of vinylarenes and vinyl heterocycles. This method has a broad scope
and enables both the synthesis of isolable silanes and the conversion
of crude products to chiral alcohols. Density functional theory calculations
support a mechanism proceeding by hydrocupration followed by σ-bond
metathesis with a hydrosilane
Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles
We
report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation
of vinylarenes and vinyl heterocycles. This method has a broad scope
and enables both the synthesis of isolable silanes and the conversion
of crude products to chiral alcohols. Density functional theory calculations
support a mechanism proceeding by hydrocupration followed by σ-bond
metathesis with a hydrosilane