Mentoring Interventions to Affect Juvenile Delinquency and Associated Problems: A Systematic Review

Mentoring is one of the most commonly used interventions to prevent, divert, and remediate youth engaged in, or thought to be at risk for delinquent behavior, school failure, aggression, or other antisocial behavior. In this update we report on a meta-analytic review of selective and indicated mentoring interventions that have been evaluated for their effects on delinquency outcomes for youth (e.g., arrest or conviction as a delinquent, self-reported involvement) and key associated outcomes (aggression, drug use, academic functioning). Of 164 identified studies published between 1970 and 2011, 46 met criteria for inclusion. Mean effects sizes were significant and positive for delinquency and academic functioning with trends (marginal significance level) for aggression and drug use. Effect sizes were modest by Cohen’s differentiation. However, there was heterogeneity in effect sizes across studies for each outcome. The obtained patterns of effects suggest mentoring may be valuable for those at-risk or already involved in delinquency and for associated outcomes. Comparison of study design (RCT vs. QE) did not show significant differences in effects. Moderator analysis showed larger effects when professional development was the motivation of the mentors for involvement, but not for basis of inclusion of participants (environmental vs. person basis of risk), presence of other interventions, or assessment of quality of fidelity. We also undertook the first systematic evaluation of key processes that seem to define how mentoring may aid youth (e.g. identification/modeling, teaching, emotional support, advocacy) to see if these related to effects. Based on studies we could code for the presence or absence of each as part of the program effort, analyses found stronger effects when emotional support and advocacy were emphasized. These results suggest mentoring is as effective for high-risk youth in relation to delinquency as many other preventive and treatment approaches and that emphasis on some theorized key processes may be more valuable than others. However, the collected set of studies is less informative than expected with quite limited specification about what comprised the mentoring program and implementation features. The juxtaposition of popular interest in mentoring and empirical evidence of benefits with the limited reporting of important features of the interventions is seen highlights the importance of more careful and extensive evaluations. Including features to understand testing of selection basis, program organization and features, implementation variations, and theorized processes for effects will greatly improve understanding of this intervention. All are essential to guide effective practice of this popular and very promising approach

Impact of Donor Milk on Short- and Long-Term Growth of Very Low Birth Weight Infants

Mother’s own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20–24 months corrected age in VLBW infants who received MOM supplements of preterm formula (n = 160) versus fortified DM (n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27.3 weeks. Multilevel linear growth models assessed changes in growth z-scores short-term (to NICU discharge) and long-term (post-discharge), controlling for amount of DM or formula received in first 28 days of life, NICU length of stay (LOS), birth GA, and sex. Z-scores for weight and length decreased during hospitalization but increased for all parameters including head circumference post-discharge. Short-term growth was positively associated with LOS and birth GA. A higher preterm formula proportion, but not DM proportion, was associated with slower rates of decline in short-term growth trajectories, but feeding type was unrelated to long-term growth. In conclusion, controlling for total human milk fed, DM did not affect short- or long-term growth

The Multisite Violence Prevention Project: Impact of a Universal School-Based Violence Prevention Program on Social-Cognitive Outcomes

This study evaluated the impact of a universal school-based violence prevention program on social-cognitive factors associated with aggression and nonviolent behavior in early adolescence. The effects of the universal intervention were evaluated within the context of a design in which two cohorts of students at 37 schools from four sites (N=5,581) were randomized to four conditions: (a) a universal intervention that involved implementing a student curriculum and teacher training with sixth grade students and teachers; (b) a selective intervention in which a family intervention was implemented with a subset of sixth grade students exhibiting high levels of aggression and social influence; (c) a combined intervention condition; and (d) a no-intervention control condition. Short-term and long-term (i.e., 2-year post-intervention) universal intervention effects on social-cognitive factors targeted by the intervention varied as a function of students' pre-intervention level of risk. High-risk students benefited from the intervention in terms of decreases in beliefs and attitudes supporting aggression, and increases in self-efficacy, beliefs and attitudes supporting nonviolent behavior. Effects on low-risk students were in the opposite direction. The differential pattern of intervention effects for low- and high-risk students may account for the absence of main effects in many previous evaluations of universal interventions for middle school youth. These findings have important research and policy implications for efforts to develop effective violence prevention programs

microbeMASST: A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms’ role in ecology and human health

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without a priori knowledge, will vastly enhance the understanding of microorganisms’ role in ecology and human health

Accuracy and Bias in Adolescents' Perceptions of Friends' Substance Use

This study tested competing hypotheses related to the false consensus effect and pluralistic ignorance by examining the accuracy and bias of adolescents’ perceptions of peer substance use, and the effects of their own substance use, gender, and age on perceptions of peer behavior. Two samples (Ns = 163 and 2,194) that collected data on peer nominations, perceptions of peer substance use, and self-reports of substance use were used in analyses. Results from both samples provided evidence supporting the false consensus effect, that is, adolescents’ reports of their friends’ substance use were biased in the direction of their own use. Users and non-users did not differ in accuracy of perceptions; however, across all substances and samples, they differed significantly in bias. Substance users displayed nearly perfect liberal bias, assuming their friends also used substances. Non-users displayed an opposite, conservative bias, assuming their friends did not use substances. Gender and age differences in bias also were observed, with older adolescents and females having more liberal biases than younger adolescents and males. Results suggest the importance of differentiating the effects of actual and perceived peer substance use

High-Dose Human Milk Feedings Decrease Oxidative Stress in Premature Infant

Background: Premature infants are susceptible to oxidative stress, increasing the risk of serious morbidities. High-dose human milk (HM) feedings decrease morbidity risks and may reduce oxidative stress in this population. The purpose of this study was to compare oxidative stress using serial urinary F2-isoprostane concentrations in predominantly HM and preterm formula (PF) fed premature infants over the first 21 days of life (DOL), while controlling for perinatal oxidative stress exposures including bovine-based human milk fortifier (HMF) or PF introduction to predominantly HM-fed infants. Methods: This was a quasi-experimental design that categorized 22 premature infants into mutually-exclusive comparison groups based on exposure to HM and PF. Serial urine samples (pre- and post-first feeding, and DOL 7, 14, and 21) were used to determine urine F2-isoprostane concentrations measured by ELISA. We analyzed data using Mann Whitney U, Wilcoxon rank test and multilevel models. Results: Comparing the predominantly HM-fed and predominantly PF-fed groups over time, median F2-isoprostane concentrations decreased significantly in the predominantly HM group (p = 0.003) and increased significantly in the predominantly PF group (p=0.01). Perinatal oxidant exposures and the introduction of HMF did not affect results. Conclusion: Our results demonstrate that predominantly HM feedings were associated with decreased oxidative stress while PF feedings increased oxidative stress in premature infants, even after controlling for perinatal oxidant exposures of HMF or PF introduction