Refactoring software development process terminology through the use of ontology

In work that is ongoing, the authors are examining the extent of software development process terminology drift. Initial findings suggest there is a degree of term confusion, with the mapping of concepts to terms lacking precision in some instances. Ontologies are concerned with identifying the concepts of relevance to a field of endeavour and mapping those concepts to terms such that term confusion is reduced. In this paper, we discuss how ontologies are developed. We also identify various sources of software process terminology. Our work to date indicates that the systematic development of a software development process ontology would be of benefit to the entire software development community. The development of such an ontology would in effect represent a systematic refactoring of the terminology and concepts produced over four decades of software process innovation

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A new species of Schindler's fish (Teleostei: Gobiidae: Schindleria) from the Malay Archipelago (Southeast Asia), with notes on the caudal fin complex of Schindleria

Ahnelt, Harald, Sauberer, Michael (2018): A new species of Schindler's fish (Teleostei: Gobiidae: Schindleria) from the Malay Archipelago (Southeast Asia), with notes on the caudal fin complex of Schindleria. Zootaxa 4531 (1): 95-108, DOI: https://doi.org/10.11646/zootaxa.4531.1.

Deep-water, offshore, and new records of Schindler's fishes, Schindleria (Teleostei, Gobiidae), from the Indo-west Pacific collected during the Dana-Expedition, 1928 - 1930

Ahnelt, Harald, Sauberer, Michael (2020): Deep-water, offshore, and new records of Schindler's fishes, Schindleria (Teleostei, Gobiidae), from the Indo-west Pacific collected during the Dana-Expedition, 1928 - 1930. Zootaxa 4731 (4): 451-470, DOI: https://doi.org/10.11646/zootaxa.4731.4.

Two new deep-water species of the genus Thorogobius (Teleostei: Gobiidae) from the upper continental slope of the Eastern Central Atlantic

Sauberer, Michael, Iwamoto, Tomio, Ahnelt, Harald (2018): Two new deep-water species of the genus Thorogobius (Teleostei: Gobiidae) from the upper continental slope of the Eastern Central Atlantic. Zootaxa 4429 (2): 357-371, DOI: https://doi.org/10.11646/zootaxa.4429.2.1

Forming a European Innovation Cluster as a Think Tank and Knowledge Pool

International audienc

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs. We used positron emission tomography (PET) with the metabolically stable P-gp/BCRP substrates [11C]tariquidar, [11C]erlotinib, and [11C]elacridar to assess whether a similar functional redundancy as at the BBB exists in the liver, where both transporters mediate the biliary excretion of drugs. Wild-type, Abcb1a/b(−/−), Abcg2(−/−), and Abcb1a/b(−/−)Abcg2(−/−) mice underwent dynamic whole-body PET scans after i.v. injection of either [11C]tariquidar, [11C]erlotinib, or [11C]elacridar. Brain uptake of all three radiotracers was markedly higher in Abcb1a/b(−/−)Abcg2(−/−) mice than in wild-type mice, while only moderately changed in Abcb1a/b(−/−) and Abcg2(−/−) mice. The transfer of radioactivity from liver to excreted bile was significantly lower in Abcb1a/b(−/−)Abcg2(−/−) mice and almost unchanged in Abcb1a/b(−/−) and Abcg2(−/−) mice (with the exception of [11C]erlotinib, for which biliary excretion was also significantly reduced in Abcg2(−/−) mice). Our data provide evidence for redundancy between P-gp and BCRP in controlling both the brain distribution and biliary excretion of dual P-gp/BCRP substrates and highlight the utility of PET as an upcoming tool to assess the effect of transporters on drug disposition at a whole-body level