Alien Registration- Poirier, Michael E. (Madison, Somerset County)

https://digitalmaine.com/alien_docs/7025/thumbnail.jp

Coping with conflicting perceptions of risk in hazardous waste facility siting disputes

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1984.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Vita.Bibliography: leaves 261-291.by Michael Lawrence Poirier Elliott.Ph.D

Guidelines for Manuscripts Describing Instructional Design or Assessment: The IDEAS Format

The article focuses on guidelines for manuscripts describing instructional design. The academic success of faculty members in higher education has been primarily based on the scholarship of research and its resultant publication. A Task Force of the American Association of Colleges of Pharmacy was charged to develop standardized criteria for manuscripts submitted to the American Journal of Pharmaceutical Education (AJPE) for the category of Instructional Design and Assessment. These guidelines apply to innovations that describe and evaluate instructional design and include new courses, parts of courses, integration of selected competencies across the curriculum (e.g., service learning, critical thinking, communication), assessment of instructional outcomes, and the use of technologies and new delivery methods

AdaWCT: Adaptive Whitening and Coloring Style Injection

Adaptive instance normalization (AdaIN) has become the standard method for style injection: by re-normalizing features through scale-and-shift operations, it has found widespread use in style transfer, image generation, and image-to-image translation. In this work, we present a generalization of AdaIN which relies on the whitening and coloring transformation (WCT) which we dub AdaWCT, that we apply for style injection in large GANs. We show, through experiments on the StarGANv2 architecture, that this generalization, albeit conceptually simple, results in significant improvements in the quality of the generated images.Comment: 4 pages + ref

Mechanism of DNA origami folding elucidated by mesoscopic simulations.

Many experimental and computational efforts have sought to understand DNA origami folding, but the time and length scales of this process pose significant challenges. Here, we present a mesoscopic model that uses a switchable force field to capture the behavior of single- and double-stranded DNA motifs and transitions between them, allowing us to simulate the folding of DNA origami up to several kilobases in size. Brownian dynamics simulations of small structures reveal a hierarchical folding process involving zipping into a partially folded precursor followed by crystallization into the final structure. We elucidate the effects of various design choices on folding order and kinetics. Larger structures are found to exhibit heterogeneous staple incorporation kinetics and frequent trapping in metastable states, as opposed to more accessible structures which exhibit first-order kinetics and virtually defect-free folding. This model opens an avenue to better understand and design DNA nanostructures for improved yield and folding performance

Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage

AbstractPoly(ADP-ribosyl)ation is a very early cellular response to DNA damage. Poly(ADP-ribose) (PAR) accumulation is transient since PAR is rapidly hydrolyzed by poly(ADP-ribose) glycohydrolase (PARG). PARG may play a prominent role in DNA damage response and repair by removing PAR from modified proteins including PARP-1. Using living cells, we provide evidence that in response to DNA damage induced by γ-irradiation the cytoplasmic 103 kDa PARG isoform translocates into the nucleus. We further observed that the nuclear GFP-hPARG110 enzyme relocalizes to the cytoplasm in response to DNA damage. Using different GFP-PARG fusion proteins specific for the nuclear and cytoplasmic forms, we demonstrate their dynamic distribution between cytoplasm and nucleoplasm and a high mobility of major PARG isoforms by fluorescence recovery after photobleaching (FRAP). The dynamic relocation of all PARG isoforms presented in this report reveals a novel biological mechanism by which PARG could be involved in DNA damage response