Radioiodination via isotope exchange in pivalic acid

A variety of benzoic and aryl aliphatic mono and polyiodinated acids and esters (sterol, triglyceride) were radioiodinated in 55-99% radiochemical yield by isotope exchange with Na 125I in a melt of pivalic acid. In general, the reaction was complete in 1 h at 155[deg]C with little or no substrate decompostion. High specific activity studies afforded 125I-labeled iopanoic acid with a specific activity of over 700 Ci/mmol.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26445/1/0000533.pd

An unexpected product from the cyclodesulfurization of 5‐[1‐(3‐methoxycarbonyl)thioureido]‐1‐(β‐D‐ribofuranosyl)imidazole‐4‐ carboxamide with dicyclohexylcarbodiimide

The treatment of 5‐[1‐(3‐methoxycarbonyl)thioureido]‐1‐(β‐D‐ribofuranosyl)imidazole‐4‐carboxamide with N,N' ‐dicyclohexylcarbodiimide in N,N ‐dimethylformamide has afforded 4‐cyano‐5‐[1‐(3‐methoxycarbonyl)‐ureido]‐1‐(β‐D‐ribofuranosyl)imidazole.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96319/1/5570230131_ftp.pd