Fast High Resolution Echelle Spectroscopy Of A Laboratory Plasma

An echelle diffraction grating and a multianode photomultiplier tube are paired to construct a high resolution (R=lambda/delta lambda approximate to 2.5x10(4)) spectrograph with fast time response for use from the UV through the visible. This instrument has analyzed the line shape of C III impurity ion emission at 229.687 nm over the lifetime (approximate to 100 mu s) of the hydrogen plasmas produced at SSX. The ion temperature and line of sight average velocity are inferred from the observed thermal broadening and Doppler shift of the line. The time resolution of these measurements is about 1 mu s, sufficient to observe the fastest magnetohydrodynamic activity

Three-Dimensional Magnetohydrodynamics Simulations Of Counter-Helicity Spheromak Merging In The Swarthmore Spheromak Experiment

Recent counter-helicity spheromak merging experiments in the Swarthmore Spheromak Experiment (SSX) have produced a novel compact torus (CT) with unusual features. These include a persistent antisymmetric toroidal magnetic field profile and a slow, nonlinear emergence of the n = 1 tilt mode. Experimental measurements are inconclusive as to whether this unique CT is a fully merged field-reversed configuration (FRC) with strong toroidal field or a partially merged doublet CT configuration with both spheromak- and FRC-like characteristics. In this paper, the SSX merging process is studied in detail using three-dimensional resistive MHD simulations from the Hybrid Magnetohydrodynamics (HYM) code. These simulations show that merging plasmas in the SSX parameter regime only partially reconnect, leaving behind a doublet CT rather than an FRC. Through direct comparisons, we show that the magnetic structure in the simulations is highly consistent with the SSX experimental observations. We also find that the n = 1 tilt mode begins as a fast growing linear mode that evolves into a slower-growing nonlinear mode before being detected experimentally. A simulation parameter scan over resistivity, viscosity, and line-tying shows that these parameters can strongly affect the behavior of both the merging process and the tilt mode. In fact, merging in certain parameter regimes is found to produce a toroidal-field-free FRC rather than a doublet CT. (C) 2011 American Institute of Physics. [doi:10.1063/1.3660533

Why Compact Tori For Fusion?

A compact torus (CT) has a toroidal magnetic and plasma geometry, but is contained within a simply-connected vacuum vessel such as a cylinder. Spheromaks and field-reversed configurations fall into this category. Compact tori are translatable and have a high engineering beta. The primary benefit of CTs for fusion is the absence of toroidal field and Ohmic Heating coils and the many problems brought on by them. Studying fusion-relevant plasma in simply-connected geometries affords the world fusion program both physics and technology opportunities not found in other configurations. This paper outlines the technology and physics opportunities of compact tori, and presents a cost model based on geometry for comparison with less compact configurations

Observation Of A Helical Self-Organized State In A Compact Toroidal Plasma

A nonaxisymmetric stable magnetohydrodynamic (MHD) equilibrium within a prolate cylindrical conducting boundary has been produced experimentally. It has m=1 azimuthal symmetry, helical distortion, and flat lambda profile, all in agreement with the computed magnetically relaxed minimum magnetic energy Taylor state. Despite varied initial conditions determined by two helicity injectors on the device, this same equilibrium consistently emerges as the final state. These results therefore describe a new example of self-organization in an MHD plasma

Stable Spheromak Formation By Merging In An Oblate Flux Conserver

An axisymmetric spheromak formed by the dynamic merging of two smaller spheromaks of the same magnetic helicity in the Swarthmore Spheromak Experiment (SSX) [M. R. Brown, Phys. Plasmas 6, 1717 (1999)] has been observed and characterized. The spheromak is formed in an oblate (tilt stable), trapezoidal, 6 mm wall copper flux conserver in SSX, which is 0.5 m in diameter and L=0.4 m in length at its largest dimensions. This configuration is formed by cohelicity merging of two spheromaks (either both right-handed or both left-handed) in which the merging poloidal fluxes are parallel (i.e., no field reversal for reconnection to occur initially). After a period of dynamic and nonaxisymmetric activity, the configuration ultimately relaxes to an axisymmetric state. A nonaxisymmetric tilted state, very close in total energy to the axisymmetric state, is also sometimes observed. This configuration is characterized by a suite of magnetic probe arrays for magnetic structure B(r,t), ion Doppler spectroscopy for T(i) and flow, and interferometry for ne. The magnetic structures of both states match well to computed eigenstates. (C) 2010 American Institute of Physics. [doi:10.1063/1.3334324

Spheromak Merging And Field Reversed Configuration Formation At The Swarthmore Spheromak Experiment

The initial results of coaxial co- and counter-helicity spheromak merging studies at the Swarthmore Spheromak Experiment (SSX) [M. R. Brown, Phys. Plasmas 6, 1717 (1999)] are reported. In its new configuration, SSX is optimized to study field reversed configuration (FRC) formation and stability by counter-helicity spheromak merging. A pair of midplane coils magnetically restricts the merging process to determine how the stability of the resulting magnetic configuration depends upon the quantity of toroidal flux remaining from the initial spheromaks. The diagnostic set at SSX, featuring the capability of measuring up to 600 magnetic field components at 800 ns time resolution, permits detailed studies of the dynamic three-dimensional magnetic structures produced during these experiments. A compact array of magnetic probes examines the local reconnection process, while a distributed array of probes examines global magnetic structure. Counter-helicity merging produces a FRC that persists for several Alfvén times, although the oppositely directed toroidal field of the initial spheromaks does not completely annihilate. The m=1 (toroidal) mode dominates late in the evolution, and is consistent with the tilt instability. Co-helicity merging produces a single elongated spheromak that rapidly tilts

Observation Of A Nonaxisymmetric Magnetohydrodynamic Self-Organized State

A nonaxisymmetric stable magnetohydrodynamic(MHD) equilibrium within a prolate cylindrical conducting boundary has been produced experimentally at Swarthmore Spheromak Experiment (SSX) [M. R. Brown et al., Phys. Plasmas6, 1717 (1999)]. It has m=1toroidal symmetry, helical distortion, and flat λ profile. Each of these observed characteristics are in agreement with the magnetically relaxed minimum magnetic energy Taylor state. The Taylor state is computed using the methods described by A. Bondeson et al. [Phys. Fluids24, 1682 (1981)] and by J. M. Finn et al. [Phys. Fluids24, 1336 (1981)] and is compared in detail to the measured internal magnetic structure. The lifetime of this nonaxisymmetric compact torus (CT) is comparable to or greater than that of the axisymmetric CTs produced at SSX; thus suggesting confinement is not degraded by its nonaxisymmetry. For both one- and two-spheromak initial state plasmas, this same equilibrium consistently emerges as the final state

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy

BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis. METHODS. The mechanism of calcipotriol action against skin carcinogenesis was examined in genetically engineered mouse models. The efficacy and safety of 0.005% calcipotriol ointment combined with 5% 5-FU cream were compared with Vaseline plus 5-FU for the field treatment of actinic keratosis in a randomized, double-blind clinical trial involving 131 participants. The assigned treatment was self-applied to the entirety of the qualified anatomical sites (face, scalp, and upper extremities) twice daily for 4 consecutive days. The percentage of reduction in the number of actinic keratoses (primary outcome), local skin reactions, and immune activation parameters were assessed. RESULTS. Calcipotriol suppressed skin cancer development in mice in a TSLP-dependent manner. Four-day application of calcipotriol plus 5-FU versus Vaseline plus 5-FU led to an 87.8% versus 26.3% mean reduction in the number of actinic keratoses in participants (P < 0.0001). Importantly, calcipotriol plus 5-FU treatment induced TSLP, HLA class II, and natural killer cell group 2D (NKG2D) ligand expression in the lesional keratinocytes associated with a marked CD4(+) T cell infiltration, which peaked on days 10–11 after treatment, without pain, crusting, or ulceration. CONCLUSION. Our findings demonstrate the synergistic effects of calcipotriol and 5-FU treatment in optimally activating a CD4(+) T cell–mediated immunity against actinic keratoses and, potentially, cancers of the skin and other organs. TRIAL REGISTRATION. ClinicalTrials.gov NCT02019355. FUNDING. Not applicable (investigator-initiated clinical trial)