The Quartic Higgs Coupling at Hadron Colliders

The quartic Higgs self-coupling is the final measurement in the Higgs potential needed to fully understand electroweak symmetry breaking. None of the present or future colliders are known to be able to determine this parameter. We study the chances of measuring the quartic self-coupling at hadron colliders in general and at the VLHC in particular. We find the prospects challenging.Comment: 5 pages, 4 figure

Hypervelocity Stars: Predicting the Spectrum of Ejection Velocities

The disruption of binary stars by the tidal field of the black hole in the Galactic Center can produce the hypervelocity stars observed in the halo. We use numerical models to simulate the full spectrum of observable velocities of stars ejected into the halo by this binary disruption process. Our model includes a range of parameters for binaries with 3-4 M_Solar primaries, consideration of radial orbits of the ejected stars through an approximate mass distribution for the Galaxy, and the impact of stellar lifetimes. We calculate the spectrum of ejection velocities and reproduce previous results for the mean ejection velocity at the Galactic center. The model predicts that the full population of ejected stars includes both the hypervelocity stars with velocities large enough to escape from the Galaxy and a comparable number of ejected, but bound, stars of the same stellar type. The predicted median speeds of the population of ejected stars as a function of distance in the halo are consistent with current observations. Combining the model with the data also shows that interesting constraints on the properties of binaries in the Galactic Center and on the mass distribution in the Galaxy can be obtained even with modest samples of ejected stars.Comment: 26 pages, including 6 figures, accepted for publication in the Astrophysical Journa

Correlations in the (Sub)Mil1imeter Background from ACT x BLAST

We present measurements of the auto- and cross-frequency correlation power spectra of the cosmic (sub)millimeter background at: 250, 350, and 500 microns (1200, 860, and 600 GHz) from observations made with the Balloon-borne Large Aperture Submillimeter Telescope, BLAST; and at 1380 and 2030 microns (218 and 148 GHz) from observations made with the Atacama Cosmology Telescope, ACT. The overlapping observations cover 8.6 deg(sup 2) in an area relatively free of Galactic dust near the south ecliptic pole (SEP). The ACT bands are sensitive to radiation from the CMB, the Sunyaev-Zel'dovich (SZ) effect from galaxy clusters, and to emission by radio and dusty star-forming galaxies (DSFGs), while the dominant contribution to the BLAST bands is from DSFGs. We confirm and extend the BLAST analysis of clustering with an independent pipeline, and also detect correlations between the ACT and BLAST maps at over 25(sigma) significance, which we interpret as a detection of the DSFGs in the ACT maps. In addition to a Poisson component in the cross-frequency power spectra, we detect a clustered signal at 4(sigma), and using a model for the DSFG evolution and number counts, we successfully fit all our spectra with a linear clustering model and a bias that depends only on red shift and not on scale. Finally, the data are compared to, and generally agree with, phenomenological models for the DSFG population. This study represents a first of its kind, and demonstrates the constraining power of the cross-frequency correlation technique to constrain models for the DSFGs. Similar analyses with more data will impose tight constraints 011 future models

Clinical and statistical correlation of various lumbar pathological conditions

AbstractCurrent clinical evaluations often rely on static anatomic imaging modalities for diagnosis of mechanical low back pain, which provide anatomic snapshots and a surrogate analysis of a functional disease. Three dimensional in vivo motion is available with the use of digital fluoroscopy, which was used to capture kinematic data of the lumbar spine in order to identify coefficients of motion that may assist the physician in differentiating patient pathology. Forty patients distributed among 4 classes of lumbar degeneration, from healthy to degenerative, underwent CT, MRI, and digital x-ray fluoroscopy. Each patient underwent diagnosis by a neurosurgeon. Fluoroscopy was taken as the patient performed lateral bending (LB), axial rotation (AR) and flexion-extension (FE). Patient specific models were registered with the fluoroscopy images to obtain in vivo kinematic data. Motion coefficients, CLB, CAR, CFE, were calculated as the ratio of in-plane motion to total out-of-plane motion. Range of motion (ROM) was calculated about the axis of motion for each exercise. Inter- and Intra- group statistics were examined for each coefficient and a flexible Bayesian classifier was used to differentiate patients with degeneration. The motion coefficients CLB and CFE were significantly different (p<0.05) in 4 of 6 group comparisons. In plane motion, ROMLB, was significantly different in only 1 of 6 group comparisons. The classifier achieved 95% sensitivity and specificity using (CFE, CLB, ROMLB) as input features, and 40% specificity and 80% sensitivity using ROM variables. The new coefficients were better correlated with patient pathology than ROM measures. The coefficients suggest a relationship between pathology and measured motion which has not been reported previously

Binary star population of the Sculptor dwarf galaxy

Aims: We aim to compute the binary fraction of "classical" dwarf spheroidal galaxies (dSphs) that are satellites of the Milky Way (MW). This value can offer insights into the binary fraction in environments that are less dense and more metal-poor than our own galaxy. Additionally, knowledge of the binary fraction in dwarf galaxies is important with respect to avoiding overestimations of their dark matter content, inferred from stellar kinematics. Methods: We refined an existing method from the literature, placing an emphasis on providing robust uncertainties on the value of the binary fraction. We applied this modified method to a VLT/FLAMES dataset for Sculptor, specifically acquired for the purpose of velocity monitoring of individual stars, as well as to literature datasets for other six MW "classical" dSphs. In all cases, the targeted stars were mainly red giant branch stars (RGBs), with expected masses of around 0.8 M$_{\odot}$. The VLT/FLAMES dataset offers the most precise binary fractions compared to literature datasets, due to its time baseline of 12 years, along with at least nine repeated observations for each star. Results: We found that the binary fraction of Sculptor is 0.55$^{+0.17}_{-0.19}$. We find that it is important to take into account the Roche lobe overflow for constraining the period distribution of binary stars. In contrast to what has recently been proposed in the literature, our analysis indicates that there is no evidence to support varying the properties of the binary stellar population or their deviations from those established for the solar neighborhood, based on the sample of MW dSphs analyzed here.Comment: 17 pages, 14 figures, Accepted for publication in Astronomy & Astrophysic

Stellar Kinematics in the Complicated Inner Spheroid of M31: Discovery of Substructure Along the Southeastern Minor Axis and its Relationship to the Giant Southern Stream

We present the discovery of a kinematically-cold stellar population along the SE minor axis of the Andromeda galaxy (M31) that is likely the forward continuation of M31's giant southern stream. This discovery was made in the course of an on-going spectroscopic survey of red giant branch (RGB) stars in M31 using the DEIMOS instrument on the Keck II 10-m telescope. Stellar kinematics are investigated in eight fields located 9-30 kpc from M31's center (in projection). A likelihood method based on photometric and spectroscopic diagnostics is used to isolate confirmed M31 RGB stars from foreground Milky Way dwarf stars: for the first time, this is done without using radial velocity as a selection criterion, allowing an unbiased study of M31's stellar kinematics. The radial velocity distribution of the 1013 M31 RGB stars shows evidence for the presence of two components. The broad (hot) component has a velocity dispersion of 129 km/s and presumably represents M31's virialized spheroid. A significant fraction (19%) of the population is in a narrow (cold) component centered near M31's systemic velocity with a velocity dispersion that decreases with increasing radial distance, from 55.5 km/s at R_proj=12 kpc to 10.6 km/s at R_proj=18 kpc. The spatial and velocity distribution of the cold component matches that of the "Southeast shelf" predicted by the Fardal et al. (2007) orbital model of the progenitor of the giant southern stream. The metallicity distribution of the cold component matches that of the giant southern stream, but is about 0.2 dex more metal rich on average than that of the hot spheroidal component. We discuss the implications of our discovery on the interpretation of the intermediate-age spheroid population found in this region in recent ultra-deep HST imaging studies.Comment: 23 pages, 16 figures, 2 tables, accepted for publication in the Astrophysical Journal. Changes from previous version: expanded discussion in sections 4.2 and 7.2, removal of section 7.1.4 and associated figure (discussion moved to section 7.1.2

Membrane Association and Destabilization by Aggregatibacter Actinomycetemcomitans Leukotoxin Requires Changes in Secondary Structures

Aggregatibacter actinomycetemcomitans is a common inhabitant of the upper aerodigestive tract of humans and non-human primates and is associated with disseminated infections, including lung and brain abscesses, pediatric infective endocarditis in children, and localized aggressive periodontitis. A. actinomycetemcomitans secretes a repeats-in-toxin protein, leukotoxin, which exclusively kills lymphocyte function-associated antigen-1-bearing cells. The toxin\u27s pathological mechanism is not fully understood; however, experimental evidence indicates that it involves the association with and subsequent destabilization of the target cell\u27s plasma membrane. We have long hypothesized that leukotoxin secondary structure is strongly correlated with membrane association and/or destabilization. In this study, we tested this hypothesis by analyzing lipid-induced changes in leukotoxin conformation. Upon incubation of leukotoxin with lipids that favor leukotoxin-membrane association, we observed an increase in leukotoxin α-helical content that was not observed with lipids that favor membrane destabilization. The change in leukotoxin conformation after incubation with these lipids suggests that membrane binding and membrane destabilization have distinct secondary structural requirements, suggesting that they are independent events. These studies thus provide insight into the mechanism of cell damage that leads to disease progression by A. actinomycetemcomitans

Precision Epoch of Reionization studies with next-generation CMB experiments

Future arcminute resolution polarization data from ground-based Cosmic Microwave Background (CMB) observations can be used to estimate the contribution to the temperature power spectrum from the primary anisotropies and to uncover the signature of reionization near $\ell=1500$ in the small angular-scale temperature measurements. Our projections are based on combining expected small-scale E-mode polarization measurements from Advanced ACTPol in the range $300<\ell<3000$ with simulated temperature data from the full Planck mission in the low and intermediate $\ell$ region, $2<\ell<2000$. We show that the six basic cosmological parameters determined from this combination of data will predict the underlying primordial temperature spectrum at high multipoles to better than $1\%$ accuracy. Assuming an efficient cleaning from multi-frequency channels of most foregrounds in the temperature data, we investigate the sensitivity to the only residual secondary component, the kinematic Sunyaev-Zel'dovich (kSZ) term. The CMB polarization is used to break degeneracies between primordial and secondary terms present in temperature and, in effect, to remove from the temperature data all but the residual kSZ term. We estimate a $15 \sigma$ detection of the diffuse homogeneous kSZ signal from expected AdvACT temperature data at $\ell>1500$, leading to a measurement of the amplitude of matter density fluctuations, $\sigma_8$, at $1\%$ precision. Alternatively, by exploring the reionization signal encoded in the patchy kSZ measurements, we bound the time and duration of the reionization with $\sigma(z_{\rm re})=1.1$ and $\sigma(\Delta z_{\rm re})=0.2$. We find that these constraints degrade rapidly with large beam sizes, which highlights the importance of arcminute-scale resolution for future CMB surveys.Comment: 10 pages, 10 figure