12,508 research outputs found
Predatory Hiring as Exclusionary Conduct: A New Perspective
The showing of predatory or exclusionary conduct is a necessary element to prove an attempted monopolization claim under section 2 of the Sherman Act. Predatory hiring as a form of exclusionary conduct has not been extensively analyzed from legal or economic perspectives. Most litigated cases have followed Universal Analytics, Inc. v. MacNeal-Schwendler Corp., where the court held that unlawful predatory hiring occurs when talent is acquired not for purposes of using that talent, but for purposes of denying it to a competitor. An anticompetitive act by a single firm is an act that is not profit maximizing but for the monopoly rents the act creates or maintains, but that is profit maximizing inclusive of those monopoly rents. However, a monopolist likely will use and derive profits from important labor talent once acquired, even if the effect of the hiring is anticompetitive. Thus, the current legal standard for proving predatory hiring as an element of an attempted monopolization claim may prevent plaintiffs from successfully prosecuting cases in which antitrust impact and injury exist. Therefore, we argue that the current legal standard required to prove a predatory-hiring claim should be revised. We use a recently litigated matter in the ambulance industry, ICare-EMS v. Rural/Metro, as a case study to make our argument. This case study is particularly revealing because, unlike most litigated matters, internal company documents and deposition testimony from plaintiff and defendant firm witnesses were not designated confidential. Therefore, we are able to illuminate the bases for the firms\u27 internal business decisions in great detail. These decisions reveal the companies\u27 intentions in ways not normally observable by antitrust scholars
Remote capacitive sensing in two-dimension quantum-dot arrays
We investigate gate-defined quantum dots in silicon on insulator nanowire
field-effect transistors fabricated using a foundry-compatible fully-depleted
silicon-on-insulator (FD-SOI) process. A series of split gates wrapped over the
silicon nanowire naturally produces a bilinear array of quantum
dots along a single nanowire. We begin by studying the capacitive coupling of
quantum dots within such a 22 array, and then show how such couplings
can be extended across two parallel silicon nanowires coupled together by
shared, electrically isolated, 'floating' electrodes. With one quantum dot
operating as a single-electron-box sensor, the floating gate serves to enhance
the charge sensitivity range, enabling it to detect charge state transitions in
a separate silicon nanowire. By comparing measurements from multiple devices we
illustrate the impact of the floating gate by quantifying both the charge
sensitivity decay as a function of dot-sensor separation and configuration
within the dual-nanowire structure.Comment: 9 pages, 3 figures, 35 cites and supplementar
Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA transcripts is an important antiviral target and is the site of interaction of the HIV-1 Tat protein together with host cellular factors. Oligonucleotides and their analogues targeted to TAR are potential antiviral candidates. We have investigated a range of cell penetrating peptide (CPP) conjugates of a 16mer peptide nucleic acid (PNA) analogue targeted to the apical stem–loop of TAR and show that disulfide-linked PNA conjugates of two types of CPP (Transportan or a novel chimeric peptide R(6)-Penetratin) exhibit dose-dependent inhibition of Tat-dependent trans-activation in a HeLa cell assay when incubated for 24 h. Activity is reached within 6 h if the lysosomotropic reagent chloroquine is co-administered. Fluorescein-labelled stably-linked conjugates of Tat, Transportan or Transportan TP10 with PNA were inactive when delivered alone, but attained trans-activation inhibition in the presence of chloroquine. Confocal microscopy showed that such fluorescently labelled CPP–PNA conjugates were sequestered in endosomal or membrane-bound compartments of HeLa cells, which varied in appearance depending on the CPP type. Co-administration of chloroquine was seen in some cases to release fluorescence from such compartments into the nucleus, but with different patterns depending on the CPP. The results show that CPP–PNA conjugates of different types can inhibit Tat-dependent trans-activation in HeLa cells and have potential for development as antiviral agents. Endosomal or membrane release is a major factor limiting nuclear delivery and trans-activation inhibition
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity
The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is limited by lack of biomarkers to optimize patient selection. We have recently identified the tumor suppressor tuberous sclerosis complex 1 (Tsc1) as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Highly variable mutations of TSC1 have been previously identified in bladder cancer and correlate with sensitivity to the Hsp90 inhibitors. Here we showed loss of TSC1 leads to hypoacetylation of Hsp90-K407/K419 and subsequent decreased binding to the Hsp90 inhibitor ganetespib. Pharmacologic inhibition of histone deacetylases (HDACs) restores acetylation of Hsp90 and sensitizes Tsc1-mutant bladder cancer cells to ganetespib, resulting in apoptosis. Our findings suggest that TSC1 status may predict response to Hsp90 inhibitors in patients with bladder cancer, and co-targeting HDACs can sensitize tumors with Tsc1 mutations to Hsp90 inhibitors
SWAS and Arecibo observations of H2O and OH in a diffuse cloud along the line-of-sight to W51
Observations of W51 with the Submillimeter Wave Astronomy Satellite (SWAS)
have yielded the first detection of water vapor in a diffuse molecular cloud.
The water vapor lies in a foreground cloud that gives rise to an absorption
feature at an LSR velocity of 6 km/s. The inferred H2O column density is
2.5E+13 cm-2. Observations with the Arecibo radio telescope of hydroxyl
molecules at ten positions in W51 imply an OH column density of 8E+13 cm-2 in
the same diffuse cloud. The observed H2O/OH ratio of ~ 0.3 is significantly
larger than an upper limit derived previously from ultraviolet observations of
the similar diffuse molecular cloud lying in front of HD 154368. The observed
variation in H2O/OH likely points to the presence in one or both of these
clouds of a warm (T > 400) gas component in which neutral-neutral reactions are
important sources of OH and/or H2O.Comment: 15 pages (AASTeX) including 4 (eps) figures. To appear in the
Astrophysical Journa
MASE: A New Data--Reduction Pipeline for the Magellan Echellette Spectrograph
We introduce a data reduction package written in Interactive Data Language
(IDL) for the Magellan Echellete Spectrograph (MAGE). MAGE is a
medium-resolution (R ~4100), cross-dispersed, optical spectrograph, with
coverage from ~3000-10000 Angstroms. The MAGE Spectral Extractor (MASE)
incorporates the entire image reduction and calibration process, including bias
subtraction, flat fielding, wavelength calibration, sky subtraction, object
extraction and flux calibration of point sources. We include examples of the
user interface and reduced spectra. We show that the wavelength calibration is
sufficient to achieve ~5 km/s RMS accuracy and relative flux calibrations
better than 10%. A light-weight version of the full reduction pipeline has been
included for real-time source extraction and signal-to-noise estimation at the
telescope.Comment: 10 pages (ApJ format), accepted PAS
Hybrid photonic circuit for multiplexed heralded single photons
A key resource for quantum optics experiments is an on-demand source of
single and multiple photon states at telecommunication wavelengths. This letter
presents a heralded single photon source based on a hybrid technology approach,
combining high efficiency periodically poled lithium niobate waveguides,
low-loss laser inscribed circuits, and fast (>1 MHz) fibre coupled
electro-optic switches. Hybrid interfacing different platforms is a promising
route to exploiting the advantages of existing technology and has permitted the
demonstration of the multiplexing of four identical sources of single photons
to one output. Since this is an integrated technology, it provides scalability
and can immediately leverage any improvements in transmission, detection and
photon production efficiencies.Comment: 5 pages, double column, 3 figure
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