Adjoint "quarks" on coarse anisotropic lattices: Implications for string breaking in full QCD

A detailed study is made of four dimensional SU(2) gauge theory with static adjoint ``quarks'' in the context of string breaking. A tadpole-improved action is used to do simulations on lattices with coarse spatial spacings $a_s$, allowing the static potential to be probed at large separations at a dramatically reduced computational cost. Highly anisotropic lattices are used, with fine temporal spacings $a_t$, in order to assess the behavior of the time-dependent effective potentials. The lattice spacings are determined from the potentials for quarks in the fundamental representation. Simulations of the Wilson loop in the adjoint representation are done, and the energies of magnetic and electric ``gluelumps'' (adjoint quark-gluon bound states) are calculated, which set the energy scale for string breaking. Correlators of gauge-fixed static quark propagators, without a connecting string of spatial links, are analyzed. Correlation functions of gluelump pairs are also considered; similar correlators have recently been proposed for observing string breaking in full QCD and other models. A thorough discussion of the relevance of Wilson loops over other operators for studies of string breaking is presented, using the simulation results presented here to support a number of new arguments.Comment: 22 pages, 14 figure

The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a single systemic dose of MAM acetate display DNA damage (O6-methyldeoxyguanosine lesions, O6-mG) that remains constant up to 7 days post-treatment. By contrast, MAM-treated mice lacking a functional gene encoding the DNA repair enzyme O6-mG DNA methyltransferase (MGMT) showed elevated O6-mG DNA damage starting at 48 hours post-treatment. The DNA damage was linked to changes in the expression of genes in cell-signaling pathways associated with cancer, human neurodegenerative disease, and neurodevelopmental disorders. These data are consistent with the established developmental neurotoxic and carcinogenic properties of MAM in rodents. They also support the hypothesis that early-life exposure to MAM-glucoside (cycasin) has an etiological association with a declining, prototypical neurodegenerative disease seen in Guam, Japan, and New Guinea populations that formerly used the neurotoxic cycad plant for food or medicine, or both. These findings suggest environmental genotoxins, specifically MAM, target common pathways involved in neurodegeneration and cancer, the outcome depending on whether the cell can divide (cancer) or not (neurodegeneration). Exposure to MAM-related environmental genotoxins may have relevance to the etiology of related tauopathies, notably, Alzheimer's disease

Aneuploidy rate is not related with the number of embryos generated in an ART cycle

Bu çalışma, 01-04 Haziran 2012 tarihleri arasında İstanbul[Türkiye]’da düzenlenen 28. Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE)’da bildiri olarak sunulmuştur.European Soc Human Reprod & Embryo

Polymer surface patterning via Diels-Alder trapping of photo-generated thioaldehydes

An efficient method for polymer surface patterning via Diels-Alder trapping of photo-generated thioaldehydes is presented. It is demonstrated that thioaldehyde end-groups generated by photolysis of phenacyl sulfides can be quantitatively trapped with various dienes. Poly(ethylene glycol) is immobilized on a surface in a spatially controlled fashion via irradiation through a shadow mask. © 2013 The Royal Society of Chemistry

(Ultra)Fast Catalyst-Free Macromolecular Conjugation in Aqueous Environment at Ambient Temperature

Tailor-made water-soluble macromolecules, including a glycopolymer, obtained by living/controlled RAFT-mediated polymerization are demonstrated to react in water with diene-functionalized poly­(ethylene glycol)­s without pre- or post-functionalization steps or the need for a catalyst at ambient temperature. As previously observed in organic solvents, hetero-Diels–Alder (HDA) conjugations reached quantitative conversion within minutes when cyclopentadienyl moieties were involved. However, while catalysts and elevated temperatures were previously necessary for open-chain diene conjugation, additive-free HDA cycloadditions occur in water within a few hours at ambient temperature. Experimental evidence for efficient conjugations is provided via unambiguous ESI-MS, UV/vis, NMR, and SEC data

Rendering, Complexity, and Perception

this paper, we propose a rendering system that is designed around these two problems. We do not claim to have a solution, rather we have a partial solution made from current technology, and a direction for future development. In Section 2 we examine the qualities required by typical computer graphics applications. Section 3 discusses how these qualities impact our modeling techniques. In Section 4 the importance of perception is expanded. Section 5 summarizes the the requirements for future renderers. In Section 6, we present our framework for a renderer satisfying these requirements. Section 7 presents directions for further work