1,531 research outputs found

    International Laser Ranging Service: Supporting Geodetic and Geophysical Research and Applications Through Satellite Laser Ranging

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    The International Laser Ranging Service: Supporting geodetic and geophysical research and applications through Satellite Laser Ranging

    Coherence between Water and Energy Policies

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    Validation of Alternating Kernel Mixture Method: Application to Tissue Segmentation of Cortical and Subcortical Structures

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    This paper describes the application of the alternating Kernel mixture (AKM) segmentation algorithm to high resolution MRI subvolumes acquired from a 1.5T scanner (hippocampus, n = 10 and prefrontal cortex, n = 9) and a 3T scanner (hippocampus, n = 10 and occipital lobe, n = 10). Segmentation of the subvolumes into cerebrospinal fluid, gray matter, and white matter tissue is validated by comparison with manual segmentation. When compared with other segmentation methods that use traditional Bayesian segmentation, AKM yields smaller errors (P < .005, exact Wilcoxon signed rank test) demonstrating the robustness and wide applicability of AKM across different structures. By generating multiple mixtures for each tissue compartment, AKM mimics the increased variation of manual segmentation in partial volumes due to the highly folded tissues. AKM's superior performance makes it useful for tissue segmentation of subcortical and cortical structures in large-scale neuroimaging studies

    Gender and Depression Moderate Response to Brief Motivational Intervention for Alcohol Misuse Among College Students

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    Objective: Brief motivational interventions (BMIs) effectively reduce problematic drinking in college students. However, not all students benefit, and little is known about the subgroups of students for whom BMIs are most effective. In the present study, we examined 2 factors that may influence BMI efficacy: gender and depression. Method: We reanalyzed data from a clinical trial in which heavy drinking students (N ϭ 330; 65% female) were randomized to a BMI (n ϭ 165) or an assessment only control (n ϭ 165). Depression was assessed at baseline; past-month typical drinks per week, heavy drinking frequency, and consequences were assessed at baseline and 1 month. Three-and 2-way interactions among intervention condition (BMI vs. control), gender (male vs. female), and depression (low vs. high) were tested. Results: We observed 3-way interaction effects on 2 outcomes: (a) typical drinks per week and (b) frequency of heavy drinking at 1 month. Relative to controls and adjusting for baseline drinking, low-depression women reduced their drinking more after a BMI whereas high-depression women did not show differential improvement. In contrast, high-depression men showed significant reductions in weekly drinks following the BMI whereas low-depression men did not show differential improvement. In addition, higher levels of depression were associated with higher levels of consequences at follow-up across conditions. Conclusions: BMIs are indicated for heavy drinking, depressed men, consistent with recommendations for implementing screening and brief intervention in mental health settings. However, BMIs may need to be refined to enhance their efficacy for depressed women
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