13 research outputs found
Universal resonant ultracold molecular scattering
The elastic scattering amplitudes of indistinguishable, bosonic,
strongly-polar molecules possess universal properties at the coldest
temperatures due to wave propagation in the long-range dipole-dipole field.
Universal scattering cross sections and anisotropic threshold angular
distributions, independent of molecular species, result from careful tuning of
the dipole moment with an applied electric field. Three distinct families of
threshold resonances also occur for specific field strengths, and can be both
qualitatively and quantitatively predicted using elementary adiabatic and
semi-classical techniques. The temperatures and densities of heteronuclear
molecular gases required to observe these univeral characteristics are
predicted. PACS numbers: 34.50.Cx, 31.15.ap, 33.15.-e, 34.20.-bComment: 4 pages, 5 figure
Response of Rubredoxin from Pyrococcus furiosus to Environmental Changes: Implications for the Origin of Hyperthermostability
The bases of the hyperthermostability of rubredoxin from Pyrococcus furiosus (RdPf) have been probed by structural perturbations induced by solution pH and ionic strength changes. Comparison of the solution behavior at pH 7 and pH 2, as probed by far- and near-UV circular dichroism, Trp
fluorescence emission, l-anilinonaphthalene-8-sulfonate (ANS) binding, and NMR spectroscopy, reveals the presence of only minimal structural variations at room temperature. At pH 2, the protein displays a surprising nearly native-like behavior at high ionic strength while, at low ionic strength, it is capable of strongly binding the hydrophobic probe ANS. All the secondary and tertiary structural features, including the environment of the hydrophobic core, appear to be intact regardless of pH and ionic strength. The apparent "melting" or denaturation temperature at pH 2, however, is 42 °C lower than at pH 7. This is attributed to the perturbation of many electrostatic interactions, including the disruption of all the ion pairs, which is complete at pH 2, as indicated by electrometric pH titrations. The implications of these
findings for the origins of the hyperthermostability of rubredoxin are discussed
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Unconventional ST2- and CD127-negative lung ILC2 populations are induced by the fungal allergen Alternaria alternata
We demonstrate that unconventional ST2- and CD127-negative ILC2 populations are present in mouse lung and are induced by Alternaria, suggesting commonly used ILC2 identification practices do not accurately enumerate the total burden of type 2 cytokine producing ILC2s