8 research outputs found
Molecular medicine and concepts of disease: the ethical value of a conceptual analysis of emerging biomedical technologies
Although it is now generally acknowledged that new biomedical technologies often produce new definitions and sometimes even new concepts of disease, this observation is rarely used in research that anticipates potential ethical issues in emerging technologies. This article argues that it is useful to start with an analysis of implied concepts of disease when anticipating ethical issues of biomedical technologies. It shows, moreover, that it is possible to do so at an early stage, i.e. when a technology is only just emerging. The specific case analysed here is that of âmolecular medicineâ. This group of emerging technologies combines a âcascade modelâ of disease processes with a âpersonal patternâ model of bodily functioning. Whereas the ethical implications of the first are partly familiar from earlierâalbeit controversialâforms of preventive and predictive medicine, those of the second are quite novel and potentially far-reaching
RELATIONSHIP BETWEEN HISTOPATHOLOGICAL LESIONS AND MAGNETIC RESONANCE IMAGING (MRI) IN DISEASES OF THE FOOT OF THE HORSE
Le nombre croissant dâĂ©tudes histopathologiques portant sur les tissus du pied a permis dâexpliquer
et de valider les variations des signaux obtenus par lâimagerie de rĂ©sonance magnĂ©tique (IRM) dans
la pratique Ă©quine clinique. En particulier, lâIRM a permis dâĂ©lucider les diffĂ©rents grades des anomalies
histologiques et peut-ĂȘtre aussi les diffĂ©rentes Ă©tapes de la progression de la dĂ©gĂ©nĂ©rescence du tendon
flĂ©chisseur profond et de lâos naviculaire. Cependant, des travaux supplĂ©mentaires sont nĂ©cessaires
pour continuer dâamĂ©liorer nos connaissances sur les diffĂ©rentes causes de boiterie du pied et leur
pathogénie.Le nombre croissant d'études
histopathologiques portant sur les tissus du pied a permis d'expliquer et de valider les
variations des signaux obtenus par l'imagerie de résonance magnétique (IRM) dans la pratique
équine clinique. En particulier, l'IRM a permis d'élucider les différents grades des
anomalies histologiques et peut-ĂȘtre aussi les diffĂ©rentes Ă©tapes de la progression de la
dégénérescence du tendon fléchisseur profond et de l'os naviculaire. Cependant, des travaux
supplémentaires sont nécessaires pour continuer d'améliorer nos connaissances sur les
différentes causes de boiterie du pied et leur pathogénie
RĂ©sultats cliniques, techniques chirurgicales, facteurs pronostiques de survie Ă court- et long-terme pour des chevaux avec hernie inguinale acquise: 98 cas (2005-2020).
peer reviewed[en] OBJECTIVE: To report findings, outcome and determine variables associated with survival in horses with acquired inguinal hernia (AIH).
STUDY DESIGN: Retrospective study.
ANIMALS: A total of 98 cases in 97 horses.
METHODS: The medical records (2005-2020) of horses diagnosed with AIH were reviewed. Retrieved data included signalment, history, clinical variables, surgical aspects, postoperative complications, and short- and long-term outcomes. Logistic regression analyses were used to determine factors associated with short-term survival (pâ<â.05).
RESULTS: Manual reduction was attempted in a third of the cases (32/98, 33%) and emergency surgery to reduce the hernia was performed in 64 of 98 (65%) cases. Concurrent small intestinal (SI) volvulus was identified in 26 (26/98, 27%) cases. Castration was the most common technique used to prevent recurrence (64/94, 68%). Overall AIH recurrence rate was 11% (11/98). A total of 59 (59/98, 60%) cases survived to hospital discharge and 49 of 52 (94%) cases were still alive after 12âmonths. Cases admitted within 10âh of colic signs had increased odds of survival (72%) compared to those admitted after 10âh (26%; pâ<â.001). Draft breeds (pâ=â.021), high heart rate on admission (pâ=â.001) and concurrent SI volvulus (pâ=â.048) were associated with reduced survival to hospital discharge.
CONCLUSIONS: Horses with AIH had a higher risk of concurrent SI volvulus and lower survival than reported. Draft breeds, high heart rate on admission and concurrent SI volvulus were associated with reduced short-term survival.
CLINICAL SIGNIFICANCE: The results of this study should help in prognostication for horses with AIH