Muscle composition in relation to the ACE I/D genotype.

<p>Whisker plots of capillary density (A), capillary-to-fibre ratio (B), and mean cross-sectional area of slow (C) and fast fibre types (D) in <i>vastus lateralis</i> muscle in relation to ACE-I/D genotypes for group 1. $, p < 0.05 vs. ACE-DD (ANOVA with post-hoc test of Fisher). Swung bracket indicates effect for combined ACE-II and ACE-ID genotypes.</p

ACE I/D genotype effects on muscle metabolism post exercise.

<p>Whisker box plots visualizing the median + standard error (boxes) and minima/maxima (Whiskers) of muscle glycogen concentration pre and post the exhaustive one leg exercise for group 1. *, p < 0.05 vs. pre; **, p < 0.001 vs. pre; $, p < 0.05 vs. ACE-DD post exercise (repeated ANOVA with post-hoc test of Fisher).</p

ACE I/D-related alterations in serum after the marathon.

<p>Whisker box plots of glucose (A) and triglyceride concentration (B) before and after the Chester Marathon for each ACE-I/D genotype for group 2. *, p < 0.05 vs. pre; $$ $, p < 0.0001 vs. ACE-DD post exercise (repeated ANOVA with post-hoc test of Fisher).</p

Genotype effects on exercise induced metabolism.

<p>Whisker box plots visualizing the median + standard error (box and central line) and minima/maxima (whisker) of serum glucose (A) and RER (B) pre and post the exhaustive one leg exercise for group 1. *, p < 0.05 vs. pre; **, p < 0.001 vs. pre; $, p < 0.05 vs. ACE-DD post exercise (repeated ANOVA with post-hoc test of Fisher). Swung bracket indicates effect for combined ACE-II and ACE-ID genotypes.</p

Muscle metabolites after exercise in relation to the ACE I/D genotype.

<p>(A-G) Whisker box plots of muscle metabolite levels being associated with pyruvate metabolism (A,B), glutathione metabolism (C,D) and amino acid metabolism (E,F), pre and post exercise per ACE-I/D genotype for group 1. Levels reflect the relative fraction of ion abundance for the respective compound (i.e. metabolite). Respective HMDB entries are provided in brackets. The main function/ ontology of each metabolite is provided in the heading. *, p < 0.05 vs. pre; $, p < 0.05 for fold changes vs. ACE-DD (SAM).</p