Relative Survival of Patients Diagnosed with Pancreatic Ductal Adenocarcinoma using SEER 9 data from 1988–2006.

<p>Survival of patients with pancreatic ductal adenocarcinoma (PC) can be separated into two qualitative phases. The first phase occurs in the initial 3 years post-PC diagnosis in which patient survival declines steeply. After 3 years post-diagnosis, PC patient survival declines much more slowly in what can be considered the second phase of the PC survival curve. The nature of these phases allows for 3-year survival to be considered a reasonable endpoint for evaluation of long-term PC patient survival. Annual survival estimates were calculated using monthly intervals.</p

Kaplan-Meier Survival Curves Comparing Patient Marital Status among patients who did not undergo cancer-directed surgery.

<p>A Kaplan-Meier survival curve comparing survival based on marital status among all patients diagnosed with pancreatic ductal adenocarcinoma (PC) between 1998 and 2003 with known marital status who <i>did not undergo</i> cancer-directed surgery. This comparison illustrates that the increased survival among married patients as compared to those who were non-married at the time of diagnosis continues to be significant regardless of if the patient was not surgically treated for his or her primary tumor. RED indicates patients who were married at the time of diagnosis and BLUE represents patients who were not married at the time of diagnosis. Total patients for each patient group, as well as total and censored patients at 12, 24, and 36 months are indicated. For each time point, “total” indicates the number of patients with ample follow-up information to determine survival at the respective time point. “Censored” indicates the number of patients who lived beyond the respective time point. This method of data representation was chosen rather than indicating at-risk patients for each time point to allow for easier interpretation of overall survival at 12, 24, and 36 months. Total patient number indicated at 0 months is equivalent to total at-risk for each patient group. For each time point, “at-risk” can be considered the number of “censored” patients from the previous time point minus the number of patients lost to follow-up between the previous and current time points. Patients lost to follow-up between time points are indicated by the respective decrease in “total” values.</p

Kaplan-Meier Survival Curves Comparing Patient Marital Status.

<p>A Kaplan-Meier survival curve comparing survival based on marital status among all patients diagnosed with pancreatic ductal adenocarcinoma (PC) between 1998 and 2003 with known marital status shows increased survival among married patients as compared to those who were non-married at the time of diagnosis. RED indicates patients who were married at the time of diagnosis and BLUE represents patients who were not married at the time of diagnosis. Total patients for each patient group, as well as total and censored patients at 12, 24, and 36 months are indicated. For each time point, “total” indicates the number of patients with ample follow-up information to determine survival at the respective time point. “Censored” indicates the number of patients who lived beyond the respective time point. This method of data representation was chosen rather than indicating at-risk patients for each time point to allow for easier interpretation of overall survival at 12, 24, and 36 months. Total patient number indicated at 0 months is equivalent to total at-risk for each patient group. For each time point, “at-risk” can be considered the number of “censored” patients from the previous time point minus the number of patients lost to follow-up between the previous and current time points. Patients lost to follow-up between time points are indicated by the respective decrease in “total” values.</p

Patient Characteristics.

<p>EBRT indicates external beam radiation therapy; A race of Other indicates Asian, or Asian-Pacific Islander.</p

Multivariate Analysis of Marital Status on Overall 2 Month and 3 year Survival in Patients with Pancreatic Ductal Adenocarcinoma With Cancer-Directed Surgery.

<p>HR indicates hazard ratio; CI indicates confidence interval; EBRT, external beam radiation therapy; A race of Other indicates Asian, or Asian-Pacific Islander.</p>≠<p>Variable shown to not be predictive of 3 year survival.</p

Univariate and Multivariate Analysis of Overall 2 month Survival in Patients with Pancreatic Ductal Adenocarcinoma.

<p>HR indicates hazard ratio; CI indicates confidence interval; EBRT, external beam radiation therapy; A race of Other indicates Asian, or Asian-Pacific Islander.</p><p>*Variable shown to not be predictive of survival in univariate analysis.</p><p>≠Variable shown to not be predictive of survival in multivariate analysis.</p

Univariate and Multivariate Analysis of Overall 3 year Survival in Patients with Pancreatic Ductal Adenocarcinoma.

<p>HR indicates hazard ratio; CI indicates confidence interval; EBRT, external beam radiation therapy; A race of Other indicates Asian, or Asian-Pacific Islander.</p><p>*Variable shown to not be predictive of survival in univariate analysis.</p><p>≠Variable shown to not be predictive of survival in multivariate analysis.</p

Kaplan-Meier Survival Curves Comparing Patient Marital Status among patients who underwent cancer-directed surgery.

<p>A Kaplan-Meier survival curve comparing survival based on marital status among all patients diagnosed with pancreatic ductal adenocarcinoma (PC) between 1998 and 2003 with known marital status who <i>underwent</i> cancer-directed surgery. This comparison illustrates that the pro-survival effects of marriage hold true among patients who underwent tumor resection, a procedure that is considered the greatest prognostic factor among patients diagnosed with pancreatic cancer. RED indicates patients who were married at the time of diagnosis and BLUE represents patients who were not married at the time of diagnosis. Total patients for each patient group, as well as total and censored patients at 12, 24, and 36 months are indicated. For each time point, “total” indicates the number of patients with ample follow-up information to determine survival at the respective time point. “Censored” indicates the number of patients who lived beyond the respective time point. This method of data representation was chosen rather than indicating at-risk patients for each time point to allow for easier interpretation of overall survival at 12, 24, and 36 months. Total patient number indicated at 0 months is equivalent to total at-risk for each patient group. For each time point, “at-risk” can be considered the number of “censored” patients from the previous time point minus the number of patients lost to follow-up between the previous and current time points. Patients lost to follow-up between time points are indicated by the respective decrease in “total” values.</p