The Meaning of Patent Citations: Report on the NBER/Case-Western Reserve Survey of Patentees

A survey of recent patentees was conducted to elicit their perceptions regarding the importance of their inventions, the extent of their communication with other inventors, and the relationship of both importance and communication to observed patent citations. A cohort of 1993 patentees were asked specifically about 2 patents that they had cited, and a third placebo' patent that was similar but which they did not cite. One of the two cited inventors was also surveyed. We find that inventors report significant communication, at least some of which is in forms that suggests spillovers from the cited inventor to the citing inventor. The perception of such communication was substantively and statistically significantly greater for the cited patents than for the placebos. There is, however, a large amount of noise in citations data; it appears that something like one-half of all citations do not correspond to any perceived communication, or even necessarily to a perceptible technological relationship between the inventions. We also find a significant correlation between the number of citations a patent received and its importance (both economic and technological) as perceived by the inventor.

Evidence from Patents and Patent Citations on the Impact of NASA and Other Federal Labs on Commercial Innovation

We explore the commercialization of government-generated technology by analyzing patents awarded to the U.S. government and the citations to those patents from subsequent patents. We use information on citations to federal patents in two ways: (1) to compare the average technological impact of NASA patents, other Federal' patents, and a random sample of all patents using measures of importance' and generality;' and (2) to trace the geographic location of commercial development by focusing on the location of inventors who cite NASA and other federal patents. We find, first, that the evidence is consistent with increased effort to commercialize federal lab technology generally and NASA specifically. The data reveal a striking NASA golden age' during the second half of the 1970s which remains a puzzle. Second, spillovers are concentrated within a federal lab complex of states representing agglomerations of labs and companies. The technology complex links five NASA states through patent citations: California, Texas, Ohio, DC/Virginia-Maryland, and Alabama. Third, qualitative evidence provides some support for the use of patent citations as proxies for both technological impact and knowledge spillovers.

Analyticity and the Isgur-Wise Function

We reconsider the recent derivation by de Rafael and Taron of bounds on the slope of the Isgur-Wise function. We argue that one must be careful to include cuts starting below the heavy meson pair production threshold, arising from heavy quark-antiquark bound states, and that if such cuts are properly accounted for then no constraints may be derived.Comment: 8 pages, uses harvmac, SLAC-PUB-5956, UCSD/PTH 92-35, CALT-68-183

The glueball spectrum from an anisotropic lattice study

The spectrum of glueballs below 4 GeV in the SU(3) pure-gauge theory is investigated using Monte Carlo simulations of gluons on several anisotropic lattices with spatial grid separations ranging from 0.1 to 0.4 fm. Systematic errors from discretization and finite volume are studied, and the continuum spin quantum numbers are identified. Care is taken to distinguish single glueball states from two-glueball and torelon-pair states. Our determination of the spectrum significantly improves upon previous Wilson action calculations.Comment: 14 pages, 8 figures, uses REVTeX and epsf.sty (final version published in Physical Review D

Characterizing Young Brown Dwarfs using Low Resolution Near-IR Spectra

We present near-infrared (1.0-2.4 micron) spectra confirming the youth and cool effective temperatures of 6 brown dwarfs and low mass stars with circumstellar disks toward the Chamaeleon II and Ophiuchus star forming regions. The spectrum of one of our objects indicates that it has a spectral type of ~L1, making it one of the latest spectral type young brown dwarfs identified to date. Comparing spectra of young brown dwarfs, field dwarfs, and giant stars, we define a 1.49-1.56 micron H2O index capable of determining spectral type to within 1 sub-type, independent of gravity. We have also defined an index based on the 1.14 micron sodium feature that is sensitive to gravity, but only weakly dependent on spectral type for field dwarfs. Our 1.14 micron Na index can be used to distinguish young cluster members (t <~ 5 Myr) from young field dwarfs, both of which may have the triangular H-band continuum shape which persists for at least tens of Myr. Using effective temperatures determined from the spectral types of our objects along with luminosities derived from near and mid-infrared photometry, we place our objects on the H-R diagram and overlay evolutionary models to estimate the masses and ages of our young sources. Three of our sources have inferred ages (t ~= 10-30 Myr) significantly older than the median stellar age of their parent clouds (1-3 Myr). For these three objects, we derive masses ~3 times greater than expected for 1-3 Myr old brown dwarfs with the bolometric luminosities of our sources. The large discrepancies in the inferred masses and ages determined using two separate, yet reasonable methods, emphasize the need for caution when deriving or exploiting brown dwarf mass and age estimates.Comment: 11 pages, Accepted to Ap

Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?)

Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics. This paper explores the limitations of such aggregated data in relation to the substance and quantification of funding for emerging technologies. Using biotechnology as an illustrative case, we test the utility of a novel taxonomy to demonstrate the endemic weaknesses in the availability and quality of data from public and private sources. Using the same taxonomy, we consider the extent to which tech-mining presents an alternative, or potentially complementary, way to determine support for emerging technologies using proxy measures such as patents and scientific publications

Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial.

BackgroundThe AspireAssist is the first Food and Drug Administration-approved endoluminal device indicated for treatment of class II and III obesity.ObjectivesWe earlier reported 1-year results of the PATHWAY study. Here, we report 4-year outcomes.SettingUnited States-based, 10-center, randomized controlled trial involving 171 participants with the treatment arm receiving Aspiration Therapy (AT) plus Lifestyle Therapy and the control arm receiving Lifestyle Therapy (2:1 randomization).MethodsAT participants were permitted to continue in the study for an additional year up to a maximum of 5 years providing they maintained at least 10% total weight loss (TWL) from baseline at each year end. For AT participants who continued the study, 5 medical monitoring visits were provided at weeks 60, 68, 76, 90, and 104 and thereafter once every 13 weeks up to week 260. Exclusion criteria were a history of eating disorder or evidence of eating disorder on a validated questionnaire. Follow-up weight, quality of life, and co-morbidities were compared with the baseline levels. In addition, rates of serious adverse event, persistent fistula, withdrawal, and A-tube replacement were reported. All analyses were performed using a per-protocol analysis.ResultsOf the 82 AT participants who completed 1 year, 58 continued to this phase of the trial. Mean baseline body mass index of these 58 patients was 41.6 ± 4.5 kg/m2. At the end of first year (at the beginning of the follow-up study), these 58 patients had a body mass index of 34.1 ± 5.4 kg/m2 and had achieved an 18.3 ± 8.0% TWL. On a per protocol basis, patients experienced 14.2%, 15.3%, 16.6%, and 18.7% TWL at 1, 2, 3, and 4 years, respectively (P &lt; .01 for all). Forty of 58 patients (69%) achieved at least 10% TWL at 4 years or at time of study withdrawal. Improvements in quality of life scores and select cardiometabolic parameters were also maintained through 4 years. There were 2 serious adverse events reported in the second through fourth years, both of which resolved with removal or replacement of the A tube. Two persistent fistulas required surgical repair, representing approximately 2% of all tube removals. There were no clinically significant metabolic or electrolytes disorders observed, nor any evidence for development of any eating disorders.ConclusionsThe results of this midterm study have shown that AT is a safe, effective, and durable weight loss alternative for people with class II and III obesity and who are willing to commit to using the therapy and adhere to adjustments in eating behavior

Summary: Combating Climate Change with Section 115 of the Clean Air Act

The scale and scope of the climate crisis calls for comprehensive nationwide efforts to reduce greenhouse gas emissions. New legislation, passed by Congress and signed by the President, is the first and best option for climate action at the federal level. This could be a version of the Green New Deal, a carbon tax, sectoral limits, an emissions cap with compliance trading, or another approach. What matters most is that the legislation effectively cut the greenhouse gas emissions driving the world’s temperatures ever higher. Unfortunately, the prospect for federal legislation is uncertain, while strong and decisive action is needed now. A president committed to tackling climate change will need a backup plan in case Congress remains gridlocked, one that relies on existing statutes to achieve the deep emission reductions the science says we need

Laser treatment in diabetic retinopathy

Diabetic retinopathy is a leading cause of visual impairment and blindness in developed countries due to macular edema and proliferative diabetic retinopathy (PDR). For both complications laser treatment may offer proven therapy: the Diabetic Retinopathy Study demonstrated that panretinal scatter photocoagulation reduces the risk of severe visual loss by >= 50% in eyes with high-risk characteristics. Pan-retinal scatter coagulation may also be beneficial in other PDR and severe nonproliferative diabetic retinopathy (NPDR) under certain conditions. For clinically significant macular edema the Early Treatment of Diabetic Retinopathy Study could show that immediate focal laser photocoagulation reduces the risk of moderate visual loss by at least 50%. When and how to perform laser treatment is described in detail, offering a proven treatment for many problems associated with diabetic retinopathy based on a high evidence level. Copyright (c) 2007 S. Karger AG, Basel

Morphological assessment of the retina in uveitis

BACKGROUND: The objective of this study is to describe a system for color photograph evaluation in uveitis and report baseline morphologic findings for the Multicenter Uveitis Steroid Treatment (MUST) Trial. Four-hundred seventy-nine eyes of 255 subjects with intermediate, posterior, and panuveitis had stereoscopic color fundus photographs obtained by certified photographers and evaluated by certified graders using standardized procedures to evaluate morphologic characteristics of uveitis. The posterior pole was evaluated for macular edema, vitreoretinal interface abnormalities, and macular pigment disturbance/atrophy; the optic disk was assessed for edema, pallor, or glaucomatous changes. The presence of neovascularization, vascular occlusion, vascular sheathing, and tractional retinal changes was determined. A random subset of 77 images was re-graded to determine the percentage agreement with the original grading on a categorical scale. RESULTS: At baseline, 437/479 eyes had images available to grade. Fifty-three eyes were completely ungradable due to media opacity. Common features of intermediate and posterior/panuveitis were epiretinal membrane (134 eyes, 35 %), and chorioretinal lesions (140 eyes, 36 %). Macular edema was seen in 16 %. Optic nerve head and vascular abnormalities were rare. Reproducibility evaluation found exact agreement for the presence of chorioretinal lesions was 78 %, the presence and location of macular edema was 71 %, and the presence of epiretinal membrane was 71 %. Vertical cup-to-disk ratio measurement had intra-class correlation of 0.75. CONCLUSIONS: The MUST system for evaluating stereoscopic color fundus photographs describes the morphology of uveitis and its sequelae, in a standardized manner, is highly reproducible, and allows monitoring of treatment effect and safety evaluation regarding these outcomes in clinical trials