7 research outputs found
Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana.
BACKGROUND:Vitamin D plays a major role in physiological processes that modulate mineral metabolism and immune function with probable link to several chronic and infectious conditions. Emerging data suggests a possible influence of vitamin D on glucose homeostasis. This study sought to provide preliminary information on vitamin D status among Ghanaian type 2 diabetics and assessed its association with glucose homeostasis. METHODS:In a case control study, 118 clinically diagnosed Type 2 Diabetes Mellitus (T2DM) patients attending Diabetic Clinic at the Nkawie Government Hospital were enrolled between October and December 2015. Hundred healthy non-diabetics living in Nkawie district were selected as controls. Structured questionnaires were administered to obtain socio-demographic data. Venous blood samples were taken from both cases and controls to estimate their FBG, Lipid profile spectrophotometrically and IPTH, 25OHD by ELISA. Statistical analyses were performed using SPSS v20.0 Statistics. RESULTS:The average age of the study participants was 58.81years for cases and 57.79year for controls. There was vitamin D deficiency of 92.4% among T2DM cases and 60.2% among the non diabetic controls. Vitamin D deficiency did not significantly associate with HOMA-β [T2DM: r2 = 0.0209, p = 0.1338 and Control: r2 = 0.0213, p = 0.2703] and HOMA-IR [T2DM: r2 = 0.0233, p = 0.1132 and Control: r2 = 0.0214, p = 0.2690] in both the controls and the cases. CONCLUSION:Vitamin D deficiency is prevalent in both T2DM and non-diabetics. There is no association between vitamin D deficiency and insulin resistance or beta cell function in our study population. Vitamin D supplementation among type 2 diabetics is recommended
Socio-demographic and clinical characteristics of study participants.
<p>Socio-demographic and clinical characteristics of study participants.</p
Prevalence and vitamin D status among T2DM and non-T2DM participants.
<p>Prevalence and vitamin D status among T2DM and non-T2DM participants.</p
Anthropometric and biochemical profile of study participants.
<p>Anthropometric and biochemical profile of study participants.</p
Linear regression between vitamin D levels and HOMA-IR in deficient and non-deficient T2DM and controls.
<p>Vitamin D deficiency did not have any statistically significant association with HOMA-IR in both the T2DM and control groups [T2DM: r<sup>2</sup> = 0.0233, p = 0.1132 and Control: r<sup>2</sup> = 0.0214, p = 0.2690] respectively Fig 1A and Fig 1C. Significant positive association was seen in T2DM with non-deficient vitamin D levels and HOMA-IR levels Fig 1B [T2DM: r<sup>2</sup> = 0.8103, p = 0.0009] but no significant association was observed for Control: r<sup>2</sup> = 0.0689, p = 0.1064] Fig 1D.</p
Baseline demographic, anthropometrics and biochemical indices of T2DM cases and control subjects stratified by vitamin D status.
<p>Baseline demographic, anthropometrics and biochemical indices of T2DM cases and control subjects stratified by vitamin D status.</p