4,905 research outputs found
Investigating the Potential of Fee-Based Recreation on Private Lands in the Lower Mississippi River Delta
Private landowners may be willing to allow public access for fee-based wildlife-associated recreation. A survey and econometric techniques are proposed to determine what characteristics may influence the probability to decide to offer recreation, what organizational form landowners may prefer to manage and market fee-based recreation, and how liability concerns and other possible disincentives collectively influence landowners' access decisions.wildlife-associated recreation, liability perceptions, Resource /Energy Economics and Policy,
European Option Pricing with Liquidity Shocks
We study the valuation and hedging problem of European options in a market
subject to liquidity shocks. Working within a Markovian regime-switching
setting, we model illiquidity as the inability to trade. To isolate the impact
of such liquidity constraints, we focus on the case where the market is
completely static in the illiquid regime. We then consider derivative pricing
using either equivalent martingale measures or exponential indifference
mechanisms. Our main results concern the analysis of the semi-linear coupled
HJB equation satisfied by the indifference price, as well as its asymptotics
when the probability of a liquidity shock is small. We then present several
numerical studies of the liquidity risk premia obtained in our models leading
to practical guidelines on how to adjust for liquidity risk in option valuation
and hedging.Comment: 25 pages, 6 figure
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and, additionally, its pharmacological activation by one compound can reduce the toxicity or efficiency of a second agent administered concomitantly. In this work, we have analysed systematically the ability of 152 research, pre-clinical or clinically used drugs to induce an NRF2 response using the MCF7-AREc32 NRF2 reporter. Ten percent of the tested drugs induced an NRF2 response. The NRF2 activators were not restricted to classical cytotoxic alkylating agents but also included a number of emerging anticancer drugs, including an IGF1-R inhibitor (NVP-AEW541), a PIM-1 kinase inhibitor (Pim1 inhibitor 2), a PLK1 inhibitor (BI 2536) and most strikingly seven of nine tested HDAC inhibitors. These findings were further confirmed by demonstrating NRF2-dependent induction of endogenous AKR genes, biomarkers of NRF2 activity. The ability of HDAC inhibitors to stimulate NRF2-signalling did not diminish their own potency as antitumour agents. However, when used to pre-treat cells, they did reduce the efficacy of acrolein. Taken together, our data suggest that the ability of drugs to stimulate NRF2 activity is common and should be investigated as part of the drug-development process
The Role of Local Policies on Resource Utilization: Timber Harvesting in St. Tammany Parish, Louisiana
Seemingly unrelated regression was used to investigate if the passage of forestry-related ordinances has had an effect upon timber harvesting activities in St. Tammany Parish, Louisiana. Results indicate that a significant negative relationship exists between a $10,000 road bond ordinance and the level of timber harvest in the Parish.Resource /Energy Economics and Policy,
Automated Quantum Oracle Synthesis with a Minimal Number of Qubits
Several prominent quantum computing algorithms--including Grover's search
algorithm and Shor's algorithm for finding the prime factorization of an
integer--employ subcircuits termed 'oracles' that embed a specific instance of
a mathematical function into a corresponding bijective function that is then
realized as a quantum circuit representation. Designing oracles, and
particularly, designing them to be optimized for a particular use case, can be
a non-trivial task. For example, the challenge of implementing quantum circuits
in the current era of NISQ-based quantum computers generally dictates that they
should be designed with a minimal number of qubits, as larger qubit counts
increase the likelihood that computations will fail due to one or more of the
qubits decohering. However, some quantum circuits require that function domain
values be preserved, which can preclude using the minimal number of qubits in
the oracle circuit. Thus, quantum oracles must be designed with a particular
application in mind. In this work, we present two methods for automatic quantum
oracle synthesis. One of these methods uses a minimal number of qubits, while
the other preserves the function domain values while also minimizing the
overall required number of qubits. For each method, we describe known quantum
circuit use cases, and illustrate implementation using an automated quantum
compilation and optimization tool to synthesize oracles for a set of benchmark
functions; we can then compare the methods with metrics including required
qubit count and quantum circuit complexity.Comment: 18 pages, 10 figures, SPIE Defense + Commercial Sensing: Quantum
Information Science, Sensing, and Computation X
The Temporal Dynamics Between Work Stressors And Health Behaviors
Applying dynamic equilibrium theory (DET), we examined the temporal dynamics between role overload and three health behaviors (sleep, diet, physical activity). Participants (N = 781) completed five surveys, with 1-month lag between assessments, and the data were analyzed using general cross-lagged panel modeling (GCLM). Results indicated that people had stable health behavior patterns (i.e., there were strong unit effects) that were related to stable role overload patterns (i.e., the chronic role overload and health behavior factors were significantly related). Furthermore, while monthly increases (impulses) in role overload had a negative effect on health behaviors concurrently, health behaviors quickly adapted or regressed back toward previous levels (i.e., there were weak autoregressive and cross-lagged effects after accounting for chronic factors). Impulse response functions were created to show the specific proportion of the initial impulse effect that persisted on each health behavior over time. The results of these response functions indicated that diet and physical activity regressed back to previous levels within 1 month, whereas sleep regressed back to previous levels within 2 months. Collectively, our results suggest that people engage in fairly stable patterns of health behaviors and that these patterns are partly determined by chronic role overload. Our results also suggest that people are generally resilient to temporary changes in role overload, such that the resulting immediate changes in behavior do not persist or become habitual. These results underscore the strength of habits and the resistance to health behavior change, as well as provide support for the use of GCLM for studying DET
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Ionizing Radiation Induced Catalysis on Metal Oxide Particles
High-level radioactive waste storage tanks at DOE sites contain significant amounts of organic components (solid and liquid phases) in the form of solvents, extractants, complexing agents, process chemicals, cleaning agents, and a variety of miscellaneous compounds. These organics pose several safety and pretreatment concerns, particularly for the Hanford tank waste. Many currently proposed tank waste cleanup alternatives encounter potential safety and/or pretreatment problems associated with organics. Remediation technologies are needed that significantly reduce the amounts of problem organics without resulting in toxic or flammable gas emissions and without requiring thermal treatments. These restrictions pose serious technological barriers for current organic destruction methods, which use oxidation achieved by thermal or chemical activation
Volunteer Income Tax Assistance (VITA) Program Dramatically Increases Knowledge Retention And Student Skills
In academia, faculty have the challenge of developing programs that will instill in the students the core competencies and skills defined by the accounting profession as the benchmark for successful entry into the accounting profession by college graduates. By integrating participation in the Volunteer Income Tax Assistance program with the teaching of concepts in the classroom at Utah Valley State College, faculty have been able to increase the retention of knowledge and the development of practical skills that benefit students, potential employers, and the community
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