Determination of physical parameters of the eclipsing binary V729 Cyg

We report new BVRI photometric observations of an eclipsing, massive binary V729 Cyg taken between 2008 and 2011. We performed light curve modeling of the new data and those available in the literature using the Wilson-Devinney code. The best fit was obtained for a contact configuration, similarly to results derived previously by other investigators. However, a huge temperature difference of about 10 000K - 12 000K was derived, inconsistent with theoretical calculations. Ruling out a possibility of V729 Cyg being a semi-detached system harbouring an accretion disk, we determined physical parameters of components

Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity

A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their tyrosinase and urease inhibitory activity. Evaluation of prepared derivatives demonstrated that compounds (8b) and (8j) are most potent mushroom tyrosinase inhibitors whereas all of the obtained compounds showed higher urease inhibitory activity than the standard thiourea. The compounds (8a), (8f) and (8i) exhibited excellent enzyme inhibitory activity with IC50 0.037, 0.044 and 0.042 μM, respectively, while IC50 of thiourea is 20.9 μM