14 research outputs found
Π’ΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΊΠΈΠ½Π°Π·Π° 1 ΠΊΠ°ΠΊ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΌΠ°ΡΠΊΠ΅Ρ: ΡΡΡΡΠΊΡΡΡΠ°, ΡΡΠ½ΠΊΡΠΈΠΈ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ ΠΈ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΡΠΊΠ°Π½ΡΡ
In the review the role of the thymidine kinase (TK) to ensure the replication of DNA de novo and spare (salvage the) way in health and activateΒ alternate ways in carcinogenesis is described. The structure of cytoplasmic TK (TΠ-1), also called fetal, and the level of regulation of its activityΒ in the cells and their change during the cell cycle is described. Considering the data about the absence of TK-1 in resting (G0) cells, TK-1Β is positioned as a marker of proliferating cells, which activity is recorded from late G1 phase, peaking in S-phase, it is stored in the G2 and mitosis,Β quickly decreasing to undetectable levels in the early G1 phase.Β Data on the expression TK-1 (as compared with Ki-67 and PCNA (proliferating cell nuclear antigen)) in tumor tissues (colorectal, breast,Β cervical, lung, renal, prostate and ovarian cancer), as well as some benign and precancerous pathological processes in relation to the clinicalΒ and diagnostic features of these processes are systemized. These data suggest that the proliferative index studies on TK-1 (antibody to the domainΒ HRA-210) should be used together with Ki-67 and PCNA, for a more complete assessment of the proliferative status of malignant tumorsΒ and pre-cancerous and benign conditions, with the aim of prognosis of the tumor process and treatment planning.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠ»ΠΈ ΡΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ (Π’Π) Π² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠΈ ΡΠ΅ΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΠ de novo ΠΈ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π·Π°ΠΏΠ°ΡΠ½ΠΎΠ³ΠΎ (salvage)Β ΠΏΡΡΠΈ Π² Π½ΠΎΡΠΌΠ΅, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π·Π°ΠΏΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ ΠΏΡΠΈ ΠΊΠ°Π½ΡΠ΅ΡΠΎΠ³Π΅Π½Π΅Π·Π΅. ΠΠΏΠΈΡΠ°Π½Ρ ΡΡΡΡΠΊΡΡΡΠ° ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π’Π (Π’Π-1),Β Π½Π°Π·ΡΠ²Π°Π΅ΠΌΠΎΠΉ ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ, ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ Π΅Π΅ ΡΡΠΎΠ²Π½Ρ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΈ ΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°.Β Π‘ ΡΡΠ΅ΡΠΎΠΌ Π΄Π°Π½Π½ΡΡ
ΠΎΠ± ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ Π’Π-1 Π² ΠΏΠΎΠΊΠΎΡΡΠΈΡ
ΡΡ (G0) ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΎΠ½Π° ΠΏΠΎΠ·ΠΈΡΠΈΠΎΠ½ΠΈΡΡΠ΅ΡΡΡ Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΊΠ°ΠΊ ΠΌΠ°ΡΠΊΠ΅Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠΈΡΡΡΡΠΈΡ
Β ΠΊΠ»Π΅ΡΠΎΠΊ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΡΡΡ, Π½Π°ΡΠΈΠ½Π°Ρ Ρ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ G1βΡΠ°Π·Ρ ΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Ρ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΠ° Π² S-ΡΠ°Π·Π΅, ΡΠΎΡ
ΡΠ°Π½ΡΠ΅ΡΡΡΒ Π² G2βΡΠ°Π·Π΅ ΠΈ ΠΌΠΈΡΠΎΠ·Π΅, Π±ΡΡΡΡΠΎ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ Π΄ΠΎ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Π² ΡΠ°Π½Π½Π΅ΠΉ G1βΡΠ°Π·Π΅.Β Π‘ΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π’Π-1 (Π² ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠΈ Ρ Ki-67 ΠΈ PCNA (proliferating cell nuclear antigen)) Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Β ΡΠΊΠ°Π½ΡΡ
(ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅, ΡΠ°ΠΊΠ΅ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ, Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΠΏΠΎΡΠΊΠΈ, ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΠΈΡΠ½ΠΈΠΊΠΎΠ²),Β Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
Π² ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠΈ Ρ ΠΈΡ
ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈΒ ΠΏΠΎ Π’Π-1 (Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΊ Π΄ΠΎΠΌΠ΅Π½Ρ XPA-210) ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π½Π°ΡΡΠ΄Ρ Ρ Ki-67 ΠΈ PCNA Π΄Π»Ρ Π±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ»Π½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΡΡ
ΠΈ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ Π² ΡΠ΅Π»ΡΡ
ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ
The influence of nitinol structure on oxidation features when heated and on corrosion resistance in chloride-containing solutions
Using the methods of differential thermal analysis and voltammetry the authors have studied the influence of grain-subgrain structure of alloys on the basis of nitinol Ti49,5Ni50,5 and Ti50,0Ni47,3Fe2,7 on the laws of their oxidation when heated in air and on corrosion resistance in chloride-containing solutions (0,9 % NaCl, artificial sea water). The alloy with submicrocrystalline structure was prepared by equal-channel angle pressing in 1-3 passages, minimum average size of grain/subgrain achieved 0,25ΞΌ. It was shown that decreasing element size of grain/subgrain structure results in reduction of alloy thermal oxidation stability which appears in fall of oxidation begining tempearture, temperatures of achieving process peak rate and full oxidation. When applying electropolishing and ion-beam processing of surface the corrosion resistance is determined to a great extent by surface state but not by alloy bulk structure. Using the mechanical polishing the iron-doped alloy with submicrocrystalline structure is more corrosion resistive than undoped TiNi with coarse-grain structure