Self-medication of abortion pills and its complications: an observational study

Background: Medical termination of pregnancy has been legalized in India since 1971. Medical abortion pill is well effective in early weeks of pregnancy. It is safe only when it is used under medical supervision. This study was carried out to analyse the complications following self-medication of abortion pills and to suggest measures to prevent such practice.Methods: This was a retrospective observational study conducted at our hospital from March 2017 to July 2017.Results: In present study 30 (75%) patients were in age group of 20-30 years. Illiterate patients were 22 (55%). Half of the patients, 20 (50%) were having three or more than three children. Majority of women 30 (75%) had consumed the abortion pills 1-10 days before coming to the hospital and 14 (35%) of patients had come with complain of excessive bleeding per vagina. Incomplete abortion was present in 32 (80%) of patients. Instrumental evacuation was required in 28 (87.5%) patients. Laparotomy for ruptured ectopic and rupture uterus was performed in 1 (2.5%) of each patient. 6 (15%) patients were severely anaemic. Transfusion of blood was required in 9 (22.5%) of patients.Conclusions: Medical abortion is effective and safe when carried out under medical supervision. Unsupervised use of medical abortion pills was associated with many complications like incomplete abortion, rupture ectopic and ruptured uterus. So, over the counter sale of medical abortion pill should be restricted

Evaluation of physico-chemical and microbial parameters on water quality of Narmada River, India

The present study was carried out to ascertain the quality of water at western zone of Narmada River of Madhya Pradesh (India). Due to heavy discharge of harmful and deleterious substances in river, the biological, chemical and physical characteristics of water have changed to a considerable extent. The objectives of this study were to find out the changes in physico-chemical nature as well as biological health of Narmada River. A thorough study was done on the basis of prevailing seasons. The deterioration of water quality was noticed at lower site of water body in a particular season as low temperature, dissolved oxygen and higher concentration of content of chlorine, etc., all pointing towards the nutrient enrichment. This evaluation will be immensely helpful to estimate the effect of impoundments on the quality of water, fisheries development and reservoir management policy. The microbial analysis was also conducted in terms of most probable number (MPN) of total coliforms in water sample and its highest value (1239) was reported from downstream of Omkareshwar dam site of Narmada River. Water quality index of all sites of Narmada River was calculated for three seasons, viz. summer, monsoon and winter and it was found to be highest (123) at Koteshwar dam site of river in monsoon season and the lowest (70) was observed in water of upstream of Omkareshwar dam during winter. The suitable correlation coefficients were calculated for 7 pairs of variables and correlation matrices were then established seasonally.Key words: Impoundments, water quality index, dissolved oxygen, most probable numbe

Cell Nucleus-Targeting Zwitterionic Carbon Dots

An innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle has been developed for anticancer drug delivery and optical monitoring. The zwitterionic functional groups of the CDs introduced by a simple one-step synthesis using beta-alanine as a passivating and zwitterionic ligand allow cytoplasmic uptake and subsequent nuclear translocation of the CDs. Moreover, multicolor fluorescence improves the accuracy of the CDs as an optical code. The CD-based drug delivery system constructed by non-covalent grafting of doxorubicin, exhibits superior antitumor efficacy owing to enhanced nuclear delivery in vitro and tumor accumulation in vivo, resulting in highly effective tumor growth inhibition. Since the zwitterionic CDs are highly biocompatible and effectively translocated into the nucleus, it provides a compelling solution to a multifunctional nanoparticle for substantially enhanced nuclear uptake of drugs and optical monitoring of translocation.open

Synthesis and biological evaluation of novel s-triazine based aryl/heteroaryl entities: Design, rationale and comparative study

The urgent need in search of new biological entities to fight back with recent drug-resistant microbial flora, has led us report a library of s-triazine derivatives. The intermediate 4-((4-chloro-6-methoxy-1,3,5-triazin-2-yl)amino)benzonitrile 3 was substituted with various thiophenol, phenol, aniline and piperazine/piperidine/morpholine moieties to furnish the final 35 target compounds i.e. (4a–j), (5a–j), (6a–g) and (7a–h), respectively. These compounds were screened for in vitro antibacterial evaluation against bacteria (Staphylococcus aureus MTCC 96, Bacillus cereus MTCC 619, Escherichia coli MTCC 739, and Pseudomonas aeruginosa MTCC 741) and antifungal activity against fungi (Candida albicans MTCC 183, Aspergillus niger MTCC 282, and Aspergillus clavatus MTCC 1323). The title compounds were further subjected for antituberculosis activity against Mycobacterium tuberculosis H37Rv strain using the BACTEC MGIT method. In this biological evaluation, thiophenol derivatives were found to be more active than the rest (i.e. -Thiophenol > -piperazine > -Aniline > -phenol). The final compounds were characterized by FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis

Self-medication of abortion pills and its complications: an observational study

Background: Medical termination of pregnancy has been legalized in India since 1971. Medical abortion pill is well effective in early weeks of pregnancy. It is safe only when it is used under medical supervision. This study was carried out to analyse the complications following self-medication of abortion pills and to suggest measures to prevent such practice.Methods: This was a retrospective observational study conducted at our hospital from March 2017 to July 2017.Results: In present study 30 (75%) patients were in age group of 20-30 years. Illiterate patients were 22 (55%). Half of the patients, 20 (50%) were having three or more than three children. Majority of women 30 (75%) had consumed the abortion pills 1-10 days before coming to the hospital and 14 (35%) of patients had come with complain of excessive bleeding per vagina. Incomplete abortion was present in 32 (80%) of patients. Instrumental evacuation was required in 28 (87.5%) patients. Laparotomy for ruptured ectopic and rupture uterus was performed in 1 (2.5%) of each patient. 6 (15%) patients were severely anaemic. Transfusion of blood was required in 9 (22.5%) of patients.Conclusions: Medical abortion is effective and safe when carried out under medical supervision. Unsupervised use of medical abortion pills was associated with many complications like incomplete abortion, rupture ectopic and ruptured uterus. So, over the counter sale of medical abortion pill should be restricted