3,614 research outputs found
Rfx6 Maintains the Functional Identity of Adult Pancreatic ÎČ Cells.
SummaryIncreasing evidence suggests that loss of ÎČ cell characteristics may cause insulin secretory deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature ÎČ cells in mice. Rfx6 loss in adult ÎČ cells leads to glucose intolerance, impaired ÎČ cell glucose sensing, and defective insulin secretion. This is associated with reduced expression of core components of the insulin secretion pathway, including glucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2+ channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of âdisallowedâ genes, a group usually specifically repressed in adult ÎČ cells, and thus to the maintenance of ÎČ cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to ÎČ cell failure in humans
Detection of single electron spin resonance in a double quantum dot
Spin-dependent transport measurements through a double quantum dot are a
valuable tool for detecting both the coherent evolution of the spin state of a
single electron as well as the hybridization of two-electron spin states. In
this paper, we discuss a model that describes the transport cycle in this
regime, including the effects of an oscillating magnetic field (causing
electron spin resonance) and the effective nuclear fields on the spin states in
the two dots. We numerically calculate the current flow due to the induced spin
flips via electron spin resonance and we study the detector efficiency for a
range of parameters. The experimental data are compared with the model and we
find a reasonable agreement.Comment: 7 pages, 5 figures. To be published in Journal of Applied Physics,
proceedings ICPS 200
Microwave sintering of dense and lattice 3Y-TZP samples shaped by digital light processing
Nowadays it is possible to produce ceramic parts with solid and complex shapes with rapid and efficient shaping and sintering techniques. In this paper, 3mol% yttria stabilized zirconia (3Y-TZP) dense and lattice parts were shaped by Digital light processing method (DLP) and densified by conventional (CV) and microwave (MW) sintering. 3Y-TZP samples were MW sintered up to 1550 °C with different heating rates (10, 30, and 50 °C/min) for the dense samples and 30 °C/min for the lattice samples. Controlled thermal cycles with a homogenous heating and no thermal runaway was reached. CV sintering was carried out at 10 °C/min up to 1550 °C. No inter-layer delamination was detected after sintering by the two methods. Both dense and lattice MW-sintered samples reached high final densities (equivalent to obtained values with CV-sintered samples, i.e., â„98% T.D.), but exhibited a lower average grain size than CV-sintered materials. The different architectures between dense and lattice samples resulted in a different specific absorbed power: the power absorbed by the dense sample is lower than that absorbed by the lattice one meaning that this sample architecture heats up easily
The EU and Asia within an evolving global order: what is Europe? Where is Asia?
The papers in this special edition are a very small selection from those presented at the EU-NESCA (Network of European Studies Centres in Asia) conference on "the EU and East Asia within an Evolving Global Order: Ideas, Actors and Processes" in November 2008 in Brussels. The conference was the culmination of three years of research activity involving workshops and conferences bringing together scholars from both regions primarily to discuss relations between Europe and Asia, perceptions of Europe in Asia, and the relationship between the European regional project and emerging regional forms in Asia. But although this was the last of the three major conferences organised by the consortium, it in many ways represented a starting point rather than the end; an opportunity to reflect on the conclusions of the first phase of collaboration and point towards new and continuing research agendas for the future
Combining clinical factors and quantitative ultrasound improves the detection of women both at low and high risk for hip fracture
Summary: We hypothesized that combining clinical risk factors (CRF) with the heel stiffness index (SI) measured via quantitative ultrasound (QUS) would improve the detection of women both at low and high risk for hip fracture. Categorizing women by risk score improved the specificity of detection to 42.4%, versus 33.8% using CRF alone and 38.4% using the SI alone. This combined CRF-SI score could be used wherever and whenever DXA is not readily accessible. Introduction and hypothesis: Several strategies have been proposed to identify women at high risk for osteoporosis-related fractures; we wanted to investigate whether combining clinical risk factors (CRF) and heel QUS parameters could provide a more accurate tool to identify women at both low and high risk for hip fracture than either CRF or QUS alone. Methods: We pooled two Caucasian cohorts, EPIDOS and SEMOF, into a large database named "EPISEMâ, in which 12,064 women, 70 to 100years old, were analyzed. Amongst all the CRF available in EPISEM, we used only the ones which were statistically significant in a Cox multivariate model. Then, we constructed a risk score, by combining the QUS-derived heel stiffness index (SI) and the following seven CRF: patient age, body mass index (BMI), fracture history, fall history, diabetes history, chair-test results, and past estrogen treatment. Results: Using the composite SI-CRF score, 42% of the women who did not report a hip fracture were found to be at low risk at baseline, and 57% of those who subsequently sustained a fracture were at high risk. Using the SI alone, corresponding percentages were 38% and 52%; using CRF alone, 34% and 53%. The number of subjects in the intermediate group was reduced from 5,400 (including 112 hip fractures) and 5,032 (including 111 hip fractures) to 4549 (including 100 including fractures) for the CRF and QUS alone versus the combination score. Conclusions: Combining clinical risk factors to heel bone ultrasound appears to correctly identify more women at low risk for hip fracture than either the stiffness index or the CRF alone; it improves the detection of women both at low and high ris
Cross-Over between universality classes in a magnetically disordered metallic wire
In this article we present numerical results of conduction in a disordered
quasi-1D wire in the possible presence of magnetic impurities. Our analysis
leads us to the study of universal properties in different conduction regimes
such as the localized and metallic ones. In particular, we analyse the
cross-over between universality classes occurring when the strength of magnetic
disorder is increased. For this purpose, we use a numerical Landauer approach,
and derive the scattering matrix of the wire from electron's Green's function.Comment: Final version, accepted for publication in New Journ. of Physics, 27
pages, 28 figures. Replaces the earlier shorter preprint arXiv:0910.427
Transport through side-coupled double quantum dots: from weak to strong interdot coupling
We report low-temperature transport measurements through a double quantum dot
device in a configuration where one of the quantum dots is coupled directly to
the source and drain electrodes, and a second (side-coupled) quantum dot
interacts electrostatically and via tunneling to the first one. As the interdot
coupling increases, a crossover from weak to strong interdot tunneling is
observed in the charge stability diagrams that present a complex pattern with
mergings and apparent crossings of Coulomb blockade peaks. While the weak
coupling regime can be understood by considering a single level on each dot, in
the intermediate and strong coupling regimes, the multi-level nature of the
quantum dots needs to be taken into account. Surprisingly, both in the strong
and weak coupling regimes, the double quantum dot states are mainly localized
on each dot for most values of the parameters. Only in an intermediate coupling
regime the device presents a single dot-like molecular behavior as the
molecular wavefunctions weight is evenly distributed between the quantum dots.
At temperatures larger than the interdot coupling energy scale, a loss of
coherence of the molecular states is observed.Comment: 9 pages, 5 figure
Computer-Assisted Proofs of Some Identities for Bessel Functions of Fractional Order
We employ computer algebra algorithms to prove a collection of identities
involving Bessel functions with half-integer orders and other special
functions. These identities appear in the famous Handbook of Mathematical
Functions, as well as in its successor, the DLMF, but their proofs were lost.
We use generating functions and symbolic summation techniques to produce new
proofs for them.Comment: Final version, some typos were corrected. 21 pages, uses svmult.cl
Remanence effects in the electrical resistivity of spin glasses
We have measured the low temperature electrical resistivity of Ag : Mn
mesoscopic spin glasses prepared by ion implantation with a concentration of
700 ppm. As expected, we observe a clear maximum in the resistivity (T ) at a
temperature in good agreement with theoretical predictions. Moreover, we
observe remanence effects at very weak magnetic fields for the resistivity
below the freezing temperature Tsg: upon Field Cooling (fc), we observe clear
deviations of (T ) as compared with the Zero Field Cooling (zfc); such
deviations appear even for very small magnetic fields, typically in the Gauss
range. This onset of remanence for very weak magnetic fields is reminiscent of
the typical signature on magnetic susceptibility measurements of the spin glass
transition for this generic glassy system
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