Quantitative obesity-related traits in the combined study sample and the population-based Inter99 cohort.

<p>Data are means±standard deviation. <i>p</i>-values were calculated assuming a recessive model (<i>p</i>_rec) for <i>INSIG2</i> rs7566605 variant (GG/GC vs. CC) and an additive model (<i>p</i>_add) for <i>PFKP</i> rs6602024 variant (GG vs. GA vs. AA) in the combined study sample (where all four study groups, the Inter99 cohort, the ADDITION cohort, the SDC population-based and type 2 diabetes sample were included) and the population-based Inter99 cohort. Known type 2 diabetic patients were excluded from the analyses. ^*Adjustments for the effect of age, sex and study group was introduced for the combined study sample, and for age and sex in the ^**population-based Inter99 cohort.</p

Effect of physical activity on the impact of the <i>INSIG2</i> rs7566605 genotype on BMI.

<p>Participants (<i>n</i> = 5,604) from the population-based Inter99 cohort, were divided according to self-reported physical activity categorised as physically passive and physically active and stratified according to <i>INSIG2</i> rs7566605 genotype applying a recessive model. Bars indicate mean BMI, and error bars indicate standard error. The number of participants (physically passive/physically active) are (1,712/3,259) for G-allele carriers and (202/431) for homozygous C-allele carriers. We tested for interaction effects using linear models, with or without, interaction parameters for physical activity compared by an ANOVA test (<i>p</i>_Int = 0.004).</p