4,226 research outputs found
Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system
We investigated whether diffusion tensor imaging (DTI) indices of white matter integrity would offer early markers of retrograde transsynaptic degeneration (RTD) in the visual system after stroke
Objective: We investigated whether diffusion tensor imaging (DTI) indices of white matter integrity
would offer early markers of retrograde transsynaptic degeneration (RTD) in the visual system
after stroke.
Methods: We performed a prospective longitudinal analysis of the sensitivity of DTI markers of
optic tract health in 12 patients with postsynaptic visual pathway stroke, 12 stroke controls,
and 28 healthy controls. We examined group differences in (1) optic tract fractional anisotropy
(FA-asymmetry), (2) perimetric measures of visual impairment, and (3) the relationship between
FA-asymmetry and perimetric assessment.
Results: FA-asymmetry was higher in patients with visual pathway lesions than in control groups.
These differences were evident 3 months from the time of injury and did not change significantly
at 12 months. Perimetric measures showed evidence of impairment in participants with visual
pathway stroke but not in control groups. A significant association was observed between
FA-asymmetry and perimetric measures at 3 months, which persisted at 12 months.
Conclusions: DTI markers of RTD are apparent 3 months from the time of injury. This represents
the earliest noninvasive evidence of RTD in any species. Furthermore, these measures associate
with measures of visual impairment. DTI measures offer a reproducible, noninvasive, and sensitive
method of investigating RTD and its role in visual impairment
Non-degenerate four-wave mixing in rubidium vapor: transient regime
We investigate the transient response of the generated light from Four-Wave
Mixing (FWM) in the diamond configuration using a step-down field excitation.
The transients show fast decay times and oscillations that depend on the
detunings and intensities of the fields. A simplified model taking into account
the thermal motion of the atoms, propagation, absorption and dispersion effects
shows qualitative agreement with the experimental observations with the energy
levels in rubidium (5S1/2, 5P1/2, 5P3/2 and 6S1/2). The atomic polarization
comes from all the contributions of different velocity classes of atoms in the
ensemble modifying dramatically the total transient behavior of the light from
FWM.Comment: 11 pages, 11 figures, to be published in Physical Review
Coherent Control of Ultracold Collisions with Chirped Light: Direction Matters
We demonstrate the ability to coherently control ultracold atomic Rb
collisions using frequency-chirped light on the nanosecond time scale. For
certain center frequencies of the chirp, the rate of inelastic trap-loss
collisions induced by negatively chirped light is dramatically suppressed
compared to the case of a positive chirp. We attribute this to a fundamental
asymmetry in the system: an excited wavepacket always moves inward on the
attractive molecular potential. For a positive chirp, the resonance condition
moves outward in time, while for a negative chirp, it moves inward, in the same
direction as the excited wavepacket; this allows multiple interactions between
the wavepacket and the light, enabling the wavepacket to be returned coherently
to the ground state. Classical and quantum calculations support this
interpretation
Levy distribution in many-particle quantum systems
Levy distribution, previously used to describe complex behavior of classical
systems, is shown to characterize that of quantum many-body systems. Using two
complimentary approaches, the canonical and grand-canonical formalisms, we
discovered that the momentum profile of a Tonks-Girardeau gas, -- a
one-dimensional gas of impenetrable (hard-core) bosons, harmonically
confined on a lattice at finite temperatures, obeys Levy distribution. Finally,
we extend our analysis to different confinement setups and demonstrate that the
tunable Levy distribution properly reproduces momentum profiles in
experimentally accessible regions. Our finding allows for calibration of
complex many-body quantum states by using a unique scaling exponent.Comment: 7 pages, 6 figures, results are generalized, new examples are adde
Preservation Methods Differ in Fecal Microbiome Stability, Affecting Suitability for Field Studies.
Immediate freezing at -20°C or below has been considered the gold standard for microbiome preservation, yet this approach is not feasible for many field studies, ranging from anthropology to wildlife conservation. Here we tested five methods for preserving human and dog fecal specimens for periods of up to 8 weeks, including such types of variation as freeze-thaw cycles and the high temperature fluctuations often encountered under field conditions. We found that three of the methods-95% ethanol, FTA cards, and the OMNIgene Gut kit-can preserve samples sufficiently well at ambient temperatures such that differences at 8 weeks are comparable to differences among technical replicates. However, even the worst methods, including those with no fixative, were able to reveal microbiome differences between species at 8 weeks and between individuals after a week, allowing meta-analyses of samples collected using various methods when the effect of interest is expected to be larger than interindividual variation (although use of a single method within a study is strongly recommended to reduce batch effects). Encouragingly for FTA cards, the differences caused by this method are systematic and can be detrended. As in other studies, we strongly caution against the use of 70% ethanol. The results, spanning 15 individuals and over 1,200 samples, provide our most comprehensive view to date of storage effects on stool and provide a paradigm for the future studies of other sample types that will be required to provide a global view of microbial diversity and its interaction among humans, animals, and the environment. IMPORTANCE Our study, spanning 15 individuals and over 1,200 samples, provides our most comprehensive view to date of storage and stabilization effects on stool. We tested five methods for preserving human and dog fecal specimens for periods of up to 8 weeks, including the types of variation often encountered under field conditions, such as freeze-thaw cycles and high temperature fluctuations. We show that several cost-effective methods provide excellent microbiome stability out to 8 weeks, opening up a range of field studies with humans and wildlife that would otherwise be cost-prohibitive
Structural dichroism in the antiferromagnetic insulating phase of V_2O_3
We performed near-edge x-ray absorption spectroscopy (XANES) at V K edge in
the antiferromagnetic insulating (AFI) phase of a 2.8% Cr-doped V_2O_3 single
crystal. Linear dichroism of several percent is measured in the hexagonal plane
and found to be in good agreement with ab-initio calculations based on multiple
scattering theory. This experiment definitively proves the structural origin of
the signal and therefore solves a controversy raised by previous
interpretations of the same dichroism as non-reciprocal. It also calls for a
further investigation of the role of the magnetoelectric annealing procedure in
cooling to the AFI phase.Comment: 4 pages 3 figures. To be published in Phys. Rev. B (2005
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