2,350 research outputs found
Alien Registration- Messer, Myrtle B. (Moscow, Somerset County)
https://digitalmaine.com/alien_docs/9285/thumbnail.jp
Time-dependent Schr\"odinger equations having isomorphic symmetry algebras. I. Classes of interrelated equations
In this paper, we focus on a general class of Schr\"odinger equations that
are time-dependent and quadratic in X and P. We transform Schr\"odinger
equations in this class, via a class of time-dependent mass equations, to a
class of solvable time-dependent oscillator equations. This transformation
consists of a unitary transformation and a change in the ``time'' variable. We
derive mathematical constraints forthe transformation and introduce two
examples.Comment: LaTeX, 18 pages, new format, edite
Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).
Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model
Ascertaining the Core Collapse Supernova Mechanism: An Emerging Picture?
Here we present the results from two sets of simulations, in two and three
spatial dimensions. In two dimensions, the simulations include multifrequency
flux-limited diffusion neutrino transport in the "ray-by-ray-plus"
approximation, two-dimensional self gravity in the Newtonian limit, and nuclear
burning through a 14-isotope alpha network. The three-dimensional simulations
are model simulations constructed to reflect the post stellar core bounce
conditions during neutrino shock reheating at the onset of explosion. They are
hydrodynamics-only models that focus on critical aspects of the shock stability
and dynamics and their impact on the supernova mechanism and explosion. In two
dimensions, we obtain explosions (although in one case weak) for two
progenitors (11 and 15 Solar mass models). Moreover, in both cases the
explosion is initiated when the inner edge of the oxygen layer accretes through
the shock. Thus, the shock is not revived while in the iron core, as previously
discussed in the literature. The three-dimensional studies of the development
of the stationary accretion shock instability (SASI) demonstrate the
fundamentally new dynamics allowed when simulations are performed in three
spatial dimensions. The predominant l=1 SASI mode gives way to a stable m=1
mode, which in turn has significant ramifications for the distribution of
angular momentum in the region between the shock and proto-neutron star and,
ultimately, for the spin of the remnant neutron star. Moreover, the
three-dimensional simulations make clear, given the increased number of degrees
of freedom, that two-dimensional models are severely limited by artificially
imposed symmetries.Comment: 9 pages, 3 figure
HLA-G: expression in human keratinocytes in vitro and in human skin in vivo
Classical, polymorphic major histocompatibility complex class I molecules are
expressed on most nucleated cells.They present peptides at the cell surface and,
thus, enable the immune system to scan peptides for their antigenicity. The
function of the other, nonclassical class I molecules in man is controversial.
HLA-G which has been shown by transfection experiments to be expressed at the
cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a
role of HLA-G in the control of rejection of the allogeneic fetus has been
discussed. We found that HLA-G expression is induced in keratinocytes by
culture in vitro. Three different alternative splicing products of HLA-G can be
detected: a full length transcript, an mRNA lacking exon 3 and a transcript devoid
of exon 3 and 4. Reverse transcription followed by polymerase chain reaction also
revealed the presence of HLA-G mRNA in vivo in biopsies of either diseased or
healthy skin
An adjudicated hermeneutic single-case efficacy design study of experiential therapy for panic/phobia
This paper illustrates the application of an adjudicated form of Hermeneutic Single Case Efficacy Design (HSCED), a critical-reflective method for inferring change and therapeutic influence in single therapy cases. The client was a 61 year-old European-American male diagnosed with panic and bridge phobia. He was seen for 23 sessions of individual Process-Experiential/Emotion-Focused Therapy. In this study, affirmative and skeptic teams of researchers developed opposing arguments regarding whether the client changed over therapy and whether therapy was responsible for these changes. Three judges representing different theoretical orientations then assessed data and arguments, rendering judgments in favor of the affirmative side. We discuss clinical implications and recommendations for the future interpretive case study research
Sediment-Phosphorus Relationships in Deer Creek Reservoir
Summary and Conclusions: Laboratory analyses of sediment samples recovered from Deer Creek Reservoir showed the sediments to have amoderate potential for serving as a source of phosphorus (P) for the overlying water solumn under anaerobic conditions. This source could account for the occurrence or exacerbation of blue-green algal blooms in the upper end of the reservoir when the sediment surface becomes anaerobic late in the summer. It could also delay the response of the reservoir to programs that decrease external P loading, if the upper end of the reservoir still has large enough algal blooms to render the sediment-water interface anaerobic. The redox cycle of Fe is closely associated with P release in the reservoir sediments, and aerobic P release rates are probably insignificant in the phosphorus budget of the reservoir. Sediment profiles indicate that the tropich state of the lake has probably not changed significantly since the reservoir was first filled. The profiles do indicate, however, that much of the P input to the lake may be in the relatively unreactive apatite-P traction, and attempts at reducing P loading from external sources should take into account the degree of availability of the P thus removed
Neutrino-driven supernovae: Boltzmann neutrino transport and the explosion mechanism
Core-collapse supernovae are, despite their spectacular visual display,
neutrino events. Virtually all of the 10^53 ergs of gravitational binding
energy released in the formation of the nascent neutron star is carried away in
the form of neutrinos and antineutrinos of all three flavors, and these
neutrinos are primarily responsible for powering the explosion. This mechanism
depends sensitively on the neutrino transport between the neutrinospheres and
the shock. In light of this, we have performed a comparison of multigroup
Boltzmann neutrino transport (MGBT) and multigroup flux-limited diffusion
(MGFLD) in post-core bounce environments. Differences in the mean inverse flux
factors, luminosities, and RMS energies translate to heating rates that are up
to 2 times larger for Boltzmann transport, with net cooling rates below the
gain radius that are typically 0.8 times the MGFLD rates. These differences are
greatest at earlier postbounce times for a given progenitor mass, and for a
given postbounce time, greater for greater progenitor mass. The increased
differences with increased progenitor mass suggest that the net heating
enhancement from MGBT is potentially robust and self-regulated.Comment: 7 pages, 2 figures, 1 table; LaTex using iopconf.sty; To appear in:
Proceedings of The Second Oak Ridge Symposium on Atomic & Nuclear
Astrophysic
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