Poopćenje potencijskog zakona za proučavanje dinamičkih sustava

We present a more general description of the technique of Tsallis and co-workers, to study the behaviour of dynamical systems. We enlarge to any dimension the power-law generalization of the classical Lyapunov exponents, that was introduced by Tsallis and co-workers in one dimension. We apply the new generalization to the two-dimensional Hénon map and consider some cases.Izlažemo poopćen opis metode Tsallisa i sur. za proučavanje svojstava dinamičkih sustava. Proširujemo poopćenje potencijskog zakona klasičnih Lyapunovih eksponenata na proizvoljan broj dimenzija po uzoru na poopćenje koje su uveli Tsallis i sur. za jednu dimenziju. Primjenjujemo to poopćenje na dvodimenzijsku Henonovu mapu i razmatramo neke slučajeve

Poopćenje potencijskog zakona za proučavanje dinamičkih sustava

We present a more general description of the technique of Tsallis and co-workers, to study the behaviour of dynamical systems. We enlarge to any dimension the power-law generalization of the classical Lyapunov exponents, that was introduced by Tsallis and co-workers in one dimension. We apply the new generalization to the two-dimensional Hénon map and consider some cases.Izlažemo poopćen opis metode Tsallisa i sur. za proučavanje svojstava dinamičkih sustava. Proširujemo poopćenje potencijskog zakona klasičnih Lyapunovih eksponenata na proizvoljan broj dimenzija po uzoru na poopćenje koje su uveli Tsallis i sur. za jednu dimenziju. Primjenjujemo to poopćenje na dvodimenzijsku Henonovu mapu i razmatramo neke slučajeve

Synthesis of bioconjugate sesterterpenoids with phospholipids and polyunsaturated fatty acids

A series of sesterterpenoid bioconjugates with phospholipids and polyunsaturated fatty acids (PUFAs) have been synthesized for biological activity testing as antiproliferative agents in several cancer cell lines. Different substitution analogues of the original lipidic ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) are obtained varying the sesterterpenoid in position 1 or 2 of the glycerol or a phosphocholine or PUFA unit in position 3. Simple bioconjugates of sesterterpenoids and eicosapentaenoic acid (EPA) have been obtained too. All synthetic derivatives were tested against the human tumour cell lines HeLa (cervix) and MCF-7 (breast). Some compounds showed good IC50 (0.3 and 0.2 μM) values against these cell lines.This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2011-30518 and SAF2014-59716-R). Junta de Castilla y León BIO/SA59/15.Peer reviewe

Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids

A series of sesterterpenoid bioconjugates with phospholipids and polyunsaturated fatty acids (PUFAs) have been synthesized for biological activity testing as antiproliferative agents in several cancer cell lines. Different substitution analogues of the original lipidic ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) are obtained varying the sesterterpenoid in position 1 or 2 of the glycerol or a phosphocholine or PUFA unit in position 3. Simple bioconjugates of sesterterpenoids and eicosapentaenoic acid (EPA) have been obtained too. All synthetic derivatives were tested against the human tumour cell lines HeLa (cervix) and MCF-7 (breast). Some compounds showed good IC50 (0.3 and 0.2 μM) values against these cell lines