State of the Northwest Arkansas Region 2019 Report

The State of the Northwest Arkansas Region Report is an annual publication, commissioned by the Northwest Arkansas Council, that serves as a tool for evaluating economic performance. In July 2018, the Northwest Arkansas Council created a new blueprint for development that outlines the peer regions and a strategic action agenda for 2018-2021. In this plan, the performance of Northwest Arkansas is benchmarked with other contemporary, high-performing regions, namely Austin, Des Moines, Madison, Durham-Chapel Hill, Raleigh and Provo-Orem. The 2019 State of the Region Report compares Northwest Arkansas with these geographies in the areas of gross domestic product, employment, unemployment, establishment growth, median household income, average annual wages, poverty, educational attainment, research and development, homeownership costs, commuting time, and average domestic airfares. The table below provides a summary of the performance of the Northwest Arkansas region on these measures. Important indicators such as gross domestic product, business establishment growth, average annual wages, and university R&D expenditures showed strong increases from the previous year, while improvements in metrics such as poverty rate and higher education attainment were more limited

Mapping Socioeconomic Indicators by Race and County in Arkansas

The Urban League of the State of Arkansas seeks to lead efforts in advancing and obtaining equal opportunities for all citizens with a particular focus in the areas of health, education, jobs, and housing. In keeping with this mission, the Urban League of Arkansas partnered with the Center for Business and Economic Research in the Sam M. Walton College of Business at the University of Arkansas to produce a report that provides data to identify key areas of need in the African American and Latinx communities in Arkansas and develop programs and policies to address them. In this report, the key areas of concern include issues around the school to prison pipeline, poverty rates, economic wellbeing, and educational attainment. The fourteen indicators included within these areas: incarceration rates, prison admissions, out-of -school suspensions, in-school suspensions, corporal punishment rates, expulsions rates, poverty rates, childhood poverty rates, labor force participation rates, unemployment rates, employment-to-population ratio rates, owner-occupied housing rates, high school/GED attainment rates, and higher education attainment rates. Data for each of these indicators was collected from 2015 to 2018 for the overall population, whites, African Americans, and Latinx from the Arkansas Department of Education, the U.S. Census Bureau, and the Arkansas Department of Corrections. Density maps for each indicator and their changes from 2015 to 2018 are presented on a county-level with versions for each population (white, African American, Latinx/Hispanic and overall)

State of the Northwest Arkansas Region 2020 Report

The State of the Northwest Arkansas Region Report is an annual publication, commissioned by the Northwest Arkansas Council, that serves as a tool for evaluating economic performance. In July 2018, the Northwest Arkansas Council created a new blueprint for development that outlines the peer regions and a strategic action agenda for 2018-2021. In this plan, the performance of Northwest Arkansas is benchmarked with other contemporary, high-performing regions, namely Austin, Des Moines, Madison, Durham-Chapel Hill, Raleigh and Provo-Orem. The 2020 State of the Region Report compares Northwest Arkansas (Fayetteville-Springdale-Rogers MSA) with these geographies in the areas of gross domestic product, employment, unemployment, establishment growth, median household income, average annual wages, poverty, educational attainment, research and development, homeownership cost, commuting time, and domestic airfare. The table below provides a summary of the performance of the Northwest Arkansas region. Important indicators such as gross domestic product, business establishment growth, average annual wages, and university R&D expenditures showed strong increases from the previous year, while improvements in metrics such as poverty rate and higher educational attainment were limited

Northwest Arkansas State of the Region Report 2021

The State of the Northwest Arkansas Region Report is an annual publication, commissioned by the Northwest Arkansas Council, that serves as a tool for evaluating economic performance. In 2018, the Northwest Arkansas Council created a strategic action agenda for 2018-2021. In this plan, the performance of Northwest Arkansas is benchmarked with other contemporary, high-performing regions: Austin, Des Moines, Madison, Durham-Chapel Hill, Raleigh and Provo-Orem. The 2021 State of the Region Report compares Northwest Arkansas with these regions in the areas of gross domestic product, employment, unemployment, establishment growth, average annual wages, research and development, and average domestic airfares. The 2020 Census was impacted by the COVID-19 pandemic and, as a result, updated data for the following indicators is not available: median household income, poverty, educational attainment, homeownership costs and commuting time

Renal endothelial dysfunction in acute kidney ischemia reperfusion injury

Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. The timing of potential therapies in animal models as they relate to the evolution of AKI, as well as the limitations of such approaches in the clinical setting are discussed. Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. We posit that the cause of the sustained impairment in kidney capillary density results from impaired endothelial growth responses and suggest that this limitation is a primary contributing feature underlying progression of chronic kidney disease

Survey of the Labor Market for New Ph.D. Hires in Economics 2022-23

This year, the survey questionnaire was sent to 369 organizations. Questionnaires were returned by 144 organizations (39.0 percent). Of this year’s responses, 86 (59.7 percent) were from those who responded to the last survey conducted for the 2021-22 academic year. Among the academic institutions responding, the distribution of highest degrees offered was as follows: Ph.D.—56.3 percent; Master’s—8.3 percent and Bachelor’s—34.7 percent. The responses are reported for all respondents, and separately for Ph.D. Degree granting institutions and for schools whose highest degree offered is the Bachelor’s or Master’s Degree. Data for the top 30 institutions in the revised National Research Council’s Research Doctorate Report, 2011, are reported as a subset of Ph.D. Degree granting schools. They are referred to as the Top 30

Survey of the Labor Market for New Ph.D. Hires in Economics 2021-2022

This year, the survey questionnaire was sent to 368 organizations. Questionnaires were returned by 144 organizations (39.1 percent). Of this year’s responses, 53 (36.8 percent) were from those who responded to the last survey conducted for the 2020-21 academic year. Among the academic institutions responding, the distribution of highest degrees offered was as follows: Ph.D.—51.4 percent; Master’s—11.8 percent and Bachelor’s—35.4 percent. The responses are reported for all respondents, and separately for Ph.D. Degree granting institutions and for schools whose highest degree offered is the Bachelor’s or Master’s Degree. Data for the top 30 institutions in the revised National Research Council’s Research Doctorate Report, 2011, are reported as a subset of Ph.D. Degree granting schools. They are referred to as the Top 30

Survey of the Labor Market for New Ph.D. Hires in Economics 2020-2021

This year, the survey questionnaire was sent to 367 organizations. Questionnaires were returned by 141 organizations (38.4 percent). Of this year’s responses, 66 (46.8 percent) were from those who responded to the last survey conducted for the 2019-20 academic year. Among the academic institutions responding, the distribution of highest degrees offered was as follows: Ph.D.—50.4 percent; Master’s—9.9 percent and Bachelor’s—38.3 percent. The responses are reported for all respondents, and separately for Ph.D. Degree granting institutions and for schools whose highest degree offered is the Bachelor’s or Master’s Degree. Data for the top 30 institutions in the revised National Research Council’s Research Doctorate Report, 2011, are reported as a subset of Ph.D. Degree grantingschools. They are referred to as the Top 30

Anti-angiogenic activity of kidney derived endothelial cells

poster abstractThe identification of novel endogenous mediators of angiogenic/vasculogenic processes may provide for novel therapeutic targets to modulate blood vessel growth in disease states, such as cardiovascular disease or cancer. Studies in our lab have shown that blood vessels in kidney have little endogenous regenerative capacity. Kidney derived microvascular endothelial cells (KEC) were isolated from rat kidney or from transgenic mice bearing the temperature sensitive SV40 mutant (and subsequently grown at non-permissive temperature, 37oC). Both rat and mouse KECs manifested significantly reduced growth rates when compared with several commonly used EC lines (rat pulmonary EC, HUVEC and human cord blood colony forming ECs). In 2D matrigel assays, all commonly used ECs faithfully formed characteristic branching structures; while all KECs failed to form stabile branching structures. Time-course analysis of branching activity demonstrated that KEC initially formed primitive branching nodes within 3 hours of culture, but these structures regressed such that no branched structures were observed between 6-12 hours. Co-culture of KECs with any branching competent EC impaired branching dose dependently. When co-cultured with ECFC, labeled KECs incorporated into primitive ECFC branches within the first 3 hours of plating. However, when compared with ECFC branches, ECFC-KEC mixed branches showed a more rapid regression of the branched structures between 12-24 hrs. Interestingly, conditioned media from KEC did not affect branching of competent ECFC. Taken together, these data indicate that KEC have anti-angiogenic activity that may destabilize ECs during angiogenesis. The anti-angiogenic activity requires cell-cell contact, suggesting the possible presence of an angio-inhibitory molecule on the cell surface of KECs. Current and future studies seek to generate additional KEC lines, and will determine if KEC cell fractions mediate the anti-angiogenic effect. In addition, we will seek to determine if KECs mitigate progression of angiogenic dependent tumor formation in vivo

Assessing identity, phenotype, and fate of endothelial progenitor cells

From the paradigm shifting observations of Harvey, Malpighi, and van Leeuwenhoek, blood vessels have become recognized as distinct and dynamic tissue entities that merge with the heart to form a closed circulatory system.1 Vessel structures are comprised predominantly of a luminal layer of endothelial cells that is surrounded by some form of basement membrane, and mural cells (pericytes or vascular smooth muscle cells) that make up the vessel wall. In larger more complex vessel structures the vessel wall is composed of a complex interwoven matrix with nerve components. Understanding the cellular and molecular basis for the formation, remodeling, repair, and regeneration of the vasculature have been and continue to be popular areas for investigation. The endothelium has become a particularly scrutinized cell population with the recognition that these cells may play important roles in maintaining vascular homeostasis and in the pathogenesis of a variety of diseases.2 Although it has been known for several decades that some shed or extruded endothelial cells enter the circulation as apparent contaminants in the human blood stream,3 only more recent technologies have permitted the identification of not only senescent sloughed endothelial cells,4 but also endothelial progenitor cells (EPCs), which have been purported to represent a normal component of the formed elements of circulating blood5 and play roles in disease pathogenesis.6–9 Most citations refer to an article published in 1997 in which Asahara and colleagues isolated, characterized, and examined the in vivo function of putative EPCs from human peripheral blood as a major impetus for generating interest in the field.10 This seminal article presented some evidence to consider emergence of a new paradigm for the process of neovascularization in the form of postnatal vasculogenesis. Since publication of that article, interest in circulating endothelial cells, and particularly EPCs, has soared, and one merely has to type the keyword search terms, endothelial progenitor cell, to recover more than 8984 articles including 1347 review articles in PubMed (as of June 2008). What can we possibly add in the form of another EPC review that will be considered of significant value for the reader? We will attempt to review some of the early article in the field and reflect on how information in those articles was gradually derivatized into perhaps more conflicting rather than unifying concepts. We will also attempt to concisely address some of the important determinants and principles that are now leading to a new understanding of what functionally constitutes an EPC and outline some of the current measures used to identify, enumerate, and quantify these cells. Finally, we give our opinion of the best definition for an EPC based on some comparative analyses performed primarily in human subjects