A-infinity algebra of an elliptic curve and Eisenstein series

We compute explicitly the A-infinity structure on the Ext-algebra of the collection $({\mathcal O}_C, L)$, where $L$ is a line bundle of degree 1 on an elliptic curve $C$. The answer involves higher derivatives of Eisenstein series.Comment: 13 pages, 3 figures; v3: added remark on the limit at the cus

Optical Spin Orientation in Strained Superlattices

Optical orientation in the strained semiconductor superlattices is investigated theoretically. The dependence of the features in spin-polarization spectra on the structure parameters is clarified. The value of polarization in the first polarization maximum in the SL structures is shown to grow with the splitting between the hh- and lh- states of the valence band, the joint strain and confinement effects on the hh1- lh1 splitting being strongly influenced by the tunneling in the barriers. In strained structures with high barriers for the holes initial polarization can exceed 95 %. Calculated polarization spectra are close to the experimental spectra of polarized electron emission.Comment: 20 pages, 8 figure

Weak localization of holes in high-mobility heterostructures

Theory of weak localization is developed for two-dimensional holes in semiconductor heterostructures. Ballistic regime of weak localization where the backscattering occurs from few impurities is studied with account for anisotropic momentum scattering of holes. The transition from weak localization to anti-localization is demonstrated for long dephasing times. For stronger dephasing the conductivity correction is negative at all hole densities due to non-monotonous dependence of the spin relaxation time on the hole wavevector. The anomalous temperature dependent correction to the conductivity is calculated. We show that the temperature dependence of the conductivity is non-monotonous at moderate hole densities.Comment: 5 pages, 4 figure

Habitation layers and pedogenic processes in forest-steppe riverine valleys west of the don: the case of iIyinka

A mesolithic site with an intrusive early medieval burial at Ilyinka in the Don basin is described. On the basis of soil analysis, environment and climate are reconstructed with reference to chronology and cultural attributio

Characterization of deep impurities in semiconductors by terahertz tunneling ionization

Tunneling ionization in high frequency fields as well as in static fields is suggested as a method for the characterization of deep impurities in semiconductors. It is shown that an analysis of the field and temperature dependences of the ionization probability allows to obtain defect parameters like the charge of the impurity, tunneling times, the Huang–Rhys parameter, the difference between optical and thermal binding energy, and the basic structure of the defect adiabatic potentials. Compared to static fields, high frequency electric fields in the terahertz-range offer various advantages, as they can be applied contactlessly and homogeneously even to bulk samples using the intense radiation of a high power pulsed far-infrared laser. Furthermore, impurity ionization with terahertz radiation can be detected as photoconductive signal with a very high sensitivity in a wide range of electric field strengths

Good Pharmacovigilance Practice in the United States and the European Union

The article presents the results of a comparative analysis of Goodpharmacovigilance practices (GVP), developed by experts of the regulatory bodiesof the European Union (EU) and the United States. It is shown that the EU GVP cover almost all possible aspects of pharmacovigilance. It is noted that the disadvantages of EU GVP are difficulties in the correct understanding and interpretation of certain definitions and processes, as well as the complexity of the implementation in practice of a number of provisions, mainly related to the organization of the quality management system, including audit and inspection. As the basis for development of the Russian Rules GVP is recommended to use the GVP E

One-dimensional Chern-Simons theory

We study a one-dimensional toy version of the Chern-Simons theory. We construct its simplicial version which comprises features of a low-energy effective gauge theory and of a topological quantum field theory in the sense of Atiyah.Comment: 37 page

S^1 \times S^2 as a bag membrane and its Einstein-Weyl geometry

In the hybrid skyrmion in which an Anti-de Sitter bag is imbedded into the skyrmion configuration a S^{1}\times S^{2} membrane is lying on the compactified spatial infinity of the bag [H. Rosu, Nuovo Cimento B 108, 313 (1993)]. The connection between the quark degrees of freedom and the mesonic ones is made through the membrane, in a way that should still be clarified from the standpoint of general relativity and topology. The S^1 \times S^2 membrane as a 3-dimensional manifold is at the same time a Weyl-Einstein space. We make here an excursion through the mathematical body of knowledge in the differential geometry and topology of these spaces which is expected to be useful for hadronic membranesComment: 9pp in latex, minor correction

Conformal Einstein equations and Cartan conformal connection

Necessary and sufficient conditions for a space-time to be conformal to an Einstein space-time are interpreted in terms of curvature restrictions for the corresponding Cartan conformal connection

Development of Medicinal Products Based on Gene-Editing Technology: Regulatory Practices

Somatic cell genome-editing systems are the most recent gene therapy technology to treat patients with monogenic hereditary cancer or HIV. Gene editing allows for changing or completely removing a defective gene with regularly interspaced short palindromic repeat (CRISPR), zinc-finger nuclease (ZFN), and transcription activator-like effector nuclease (TALEN) systems.The aim of the study was to analyse the existing international experience and regulatory requirements relating to the development of medicinal products based on genome editing of postnatal somatic cells.This article describes the mechanism of action of CRISPR, ZFN, and TALEN systems and compares their advantages and disadvantages. Regulatory and legislative authorities should take a special approach to the development, manufacture, and assessment of medicinal products based on genome editing, as well as to the ethical aspects of their use. Current requirements and recommendations for the development of medicinal products based on genome editing are mostly limited to the need to evaluate the risks of off-target effects and late-onset adverse events and the possibility to adapt clinical trial design to surrogate endpoints, exclude healthy volunteers and comparison groups, and select initial doses for clinical trials based on scientific data. Thus, a regulatory approach should also be developed for the marketing authorisation of medicinal products based on genome-editing systems