Integrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities

Motivation: The analysis of a number of different genetic features like copy number (CN) variation, gene expression (GE) or loss of heterocygosity has considerably increased in recent years, as well as the number of available datasets. This is particularly due to the success of microarray technology. Thus, to understand mechanisms of disease pathogenesis on a molecular basis, e.g. in cancer research, the challenge of analyzing such different data types in an integrated way has become increasingly important. In order to tackle this problem, we propose a new procedure for an integrated analysis of two different data types that searches for genes and genetic regions which for both inputs display strong equally directed deviations from the reference median. We employ this approach, based on a modified correlation coefficient and an explorative Wilcoxon test, to find DNA regions of such abnormalities in GE and CN (e.g. underexpressed genes accompanied by a loss of DNA material). Results: In an application to acute myeloid leukemia, our procedure is able to identify various regions on different chromosomes with characteristic abnormalities in GE and CN data and shows a higher sensitivity to differences in abnormalities than standard approaches. While the results support various findings of previous studies, some new interesting DNA regions can be identified. In a simulation study, our procedure also shows more reliable results than standard approaches. Availability: Code and data available as R packages edira and ediraAMLdata from http://www.statistik.tu-dortmund.de/~schaefer/ Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics onlin

The applying of three-dimensional reconstruction for planning and supporting surgical operations

Аппаратно-программный комплекс для помощи хирургу во время проведения операции,представляет собой систему отображения набора анатомических компьютерных 3D моделей зоны интереса на дисплее в хирургической операционной. Данные анатомические модели получаются в результате предварительной реконструкции на основе сегментации медицинских изображений, таких модальностей как КТ, МРТ, ПЭТ и др. Аппаратно-программный комплекс поддержки проведения хирургического вмешательства включает в себя также систему захвата движения, предназначенную длябесконтактного управления, за сч?т жестов оператора набором анатомических 3D моделей на дисплее. Система позволяет управлять положением набора 3D моделей, их масштабом и прозрачностью отдельных моделей, а также перемещаться между наборами 3D моделей, построенных для различных стадий проведения хирургической операции.Hardware and software system to assist the surgeon during surgery. This is a system for displaying a set ofanatomical 3D computer models of regions of interest on display in the surgery. These anatomical models areobtained by a preliminary reconstruction based segmentation of medical images of such modalities as CT, MRI,PET, etc. Hardware and software system support surgery also includes motion-capture system designed for contactmanagement, through gestures of the operator, a set of 3D anatomical models on display. The system allows tocontrol the position of the set of 3D models, their scale and transparency of individual models and to navigatebetween sets of 3D models for various stages of the surgery

Обоснование выбора электродвигателя и схемы его включения для системы точного поддержания скорости

Рассматривается применение в системах точного поддержания скорости различных синхронных электродвигателей. В результате сравнения рекомендовано применение в таких системах конденсаторного синхронного реактивного двигателя с трехфазными обмотками статора. Это позволяет упростить и удешевить систему точного электропривода и повысить ее надежность

On the physical nature of photon and the modeling of its wave function of free propagation in space and time

In the framework of quantum mechanics the physical nature of the photon is discussed. It is substantiated that a photon is a quantum quasiparticle, the free propagation of which must be considered taking into account the processes in a physical vacuum at Planck distances. For practical purposes on a macroscopic scale, the photon propagation can be modeled using the wave function (wave packet) normalized to the unit probability in the coordinate representation

Совершенствование управленческого учета на предприятии

Объектом исследования является группа компаний, производящая Эко-продукты. Цель работы – совершенствование системы управленческого учета группы компаний в части формирования финансовой отчетности. В процессе исследования были изучены теоретические аспекты управленческого учета, а также методы и инструменты, используемые в нем. Рассмотрена роль управленческого учета в информационном обеспечении руководства предприятия. Проводилась организационно-экономическая характеристика предприятия, в рамках которой была рассмотрена действующая организационная структура и проведен финансовый анализ. Проанализирована действующая система управленческого учета группы компаний. Проведен финансовый анализ по двум формам отчетности.The object of research is a group of companies that produce eco-products. The purpose of the work is to improve the management accounting system of a group of companies in terms of the formation of financial statements. During the study, the theoretical aspects of management accounting were studied, as well as the methods and tools used in it. The role of management accounting in the information support of enterprise management is considered. The organizational and economic characteristics of the enterprise were carried out, in the framework of which the current organizational structure was reviewed and a financial analysis was carried out. The current management accounting system of a group of companies is analyzed. Conducted financial analysis in two reporting forms

Oh the first was number one, and she wanted to have some fun

Bawdy song.No ref