Incident infection estimates based on models adjusting for possible selection bias.

<p>S₁, no adjustment; S₂, model with adjustment for selection bias exerted by seeking early testing after a suspected exposure; S₃, model with adjustment for seeking medical attention due to symptoms of acute HIV infection. Refer to Methods for further explanations. The blue curve without symbols on top in each panel shows the number of HIV notifications.</p

Characteristics of the 3’851 HIV notifications received 2008–2013.

<p>IQR, interquartile range;</p><p>* all infected abroad;</p><p>** predominantly infected abroad</p><p>Characteristics of the 3’851 HIV notifications received 2008–2013.</p

HIV-1 infections ruled incident by the 10 best-performing Inno-Lia algorithms.

<p>Analysis restricted to notifications that contained Inno-Lia results.</p><p>HIV-1 infections ruled incident by the 10 best-performing Inno-Lia algorithms.</p

Number of HIV notifications and incident HIV infections over time, as obtained by performance-based and window-based incident infection estimates.

<p>Panels on top labeled “All” show the data for all patients, lower panels show the data per risk category (MSM, men who have sex with men; HET, heterosexual transmission; IDU, intravenous drug use; UNK, unknown transmission pathway). In all panels, the blue curve with the circle symbols denotes the annual number of HIV notifications, and the black curve without symbols shows the estimated number of incident infections (means and their 95% confidence intervals). The top panels also show the results obtained with the 10 individual algorithms (grey lines in the background).</p

Incident infection estimates based on models adjusting for possible selection bias.

<p>S₁, no adjustment; S₂, model with adjustment for selection bias exerted by seeking early testing after a suspected exposure; S₃, model with adjustment for seeking medical attention due to symptoms of acute HIV infection. Refer to Methods for further explanations. The blue curve without symbols on top in each panel shows the number of HIV notifications.</p

Incident HIV-1 infection estimates utilizing the performance-based method.

<p>Incident HIV-1 infection estimates utilizing the performance-based method.</p

Factors associated with liver histological activity.

<p>Note: stepwise logistic regression (cutoff P = 0.15).</p><p>Factors associated with liver histological activity.</p

Association of CCR5delta32 with different HCV-related endpoints.

1<p>Due to the relative low CCR5delta32 allele frequency (8.6%), data are presented for the dominant mode of inheritance.</p>2<p>The number patients carrying 0, 1 or 2 copies of CCR5delta32 were 1073, 202 and 15 for patients with chronic infection and 143, 16 and 1 for spontaneous clearers. The associations were also tested by using the additive (OR = 0.61, 95% CI 0.38–1.00, P = 0.05) and recessive (OR = 0.53, 95% CI 0.07–4.07, P = 0.5) modes of inheritance. The association was similar albeit less significant when patients with positive HIV serology were removed (OR = 0.63, 95% CI 0.36–1.08, P = 0.09).</p><p>Association of CCR5delta32 with different HCV-related endpoints.</p

Patient characteristics.

<p>Numbers are the proportion of patients with the indicated feature.</p>1<p>Gender was missing in 1 patient with spontaneous clearance.</p>2<p>Age at estimated date of infection for patients with chronic infection, at cohort entry for those with spontaneous clearance (missing in 2 patients).</p>3<p>HCV genotype was missing in most patients with spontaneous clearance and in 46 chronically infected patients.</p>4<p>Alcohol consumption data before treatment was missing in 18 patients.</p>5<p>BMI treatment was missing in 215 patients.</p>6<p>HIV serology was missing in 214 patients.</p>7<p>Response treatment was assessable in 693 patients.</p>8<p>Histological activity before treatment was missing in 279 patients.</p>9<p>Fibrosis stage before treatment was missing in 273 patients.</p>10<p>Steatosis data before treatment were missing in 155 patients.</p><p>Patient characteristics.</p