1 research outputs found
GreenMedChem : the challenge in the next decade toward eco-friendly compounds and processes in drug design
Green chemistry has become a hot topic and the focus of not only many companies but also researchers.
Green chemistry strives to identify alternative and environmentally friendly reaction conditions and simultaneously aims to increase the rates and reduce the temperature of reactions. Specifically, the goal of
green chemistry is to reduce the impact of chemical substances and processes on human health and the
effective elimination of environmental pollution through dedicated sustainable prevention programs.
Green chemistry is based on innovative scientific solutions to solve environmental problems that arise in
the laboratory. In this review, we analyse in detail each of the 12 Principles of Green Chemistry developed
by Paul Anastas in 1991, emphasising the aspects of medicinal chemistry carried out in research laboratories for the synthesis of active pharmaceutical ingredients (API). Here, we provide some examples of
greener reactions, which can substitute the older strategies carried out by both industries and academia
and offer a guide to improve the greenness of reactions. The present review highlights the methods that
can be used by medicinal chemists in their daily work not only to improve the yields but also to reduce
and prevent pollution, thereby protecting the environment and our health