851 research outputs found
Alien Registration- Taylor, Mercy J. (Blaine, Aroostook County)
https://digitalmaine.com/alien_docs/26047/thumbnail.jp
Impact of COVID-19 lockdown in Tamil Nadu: Benefits and challenges on environment perspective
Prior to COVID-19 lockdown in our country, the air around us was highly polluted due to emission of greenhouse gases for over centuries. Melting of glaciers and rising of the sea levels were evidenced as the alarming signs of Global warming. Environmental degradation was observed rapidly due to depletion and exploitation of natural resources like soil, water and air. But there are few changes observed in the environment after the country’s lockdown due to coronavirus pandemic. The effects of lockdown are also entwined with human and political effects such as uncontrollable public mobility, poor access to health care due to lack of sufficient medical facilities, unemployment, migrants’ crisis, starvation and prevailing poverty. However, apart from sufferings of entire country especially the people by social, economic and psychologic effects in day-to-day life, this lockdown has given to the nature the most optimistic scenarios in environment especially with enhanced air quality, cleaner water and undisturbed pristine forest. The present review brings out the actual picture of the eco-processes that reduced man-made pollution in air and water as well as disposal of domestic or biological waste along with societal implications after imposing lockdown in the state of Tamil Nadu
Community-led total sanitation (CLTS) in fragile contexts: the Somalia case
This paper presents the lessons learnt from a pilot CLTS intervention in the challenging context of Somalia. This experience presents the challenges in contexts where highly subsidised latrine construction was previously applied. Results show that it is still possible to trigger to a great extent a community ‘with a desire for change with regards to open defecation and facilitate them to build their own household latrines without subsidisation’. Hundreds of latrines have been constructed and Open Defecation Free status achieved in two locations in Gedo Region in South Somalia where no subsidy was provided, while not a single latrine has been constructed by households in 14 villages in Gabiley Region where subsidy was provided. Households that didn’t receive subsidy are still waiting for it and open defecation continues. Commitment, attitude and mind-set of the implementers, community and the local authority are key to success in any context – fragile or stable
SOSIALISASI KESADARAN LINGKUNGAN DIFERENSIASI MANGROVE BERBASIS PjBL STEAM PADA PESERTA DIDIK DI PESISIR PULAU AMBON
The socialization of mangrove differentiated environmental awareness based on PjBL STEAM aims to produce high-order thinking skills oriented products by implementing them in learning. In addition to producing art products about mangrove plants. This activity was motivated by the teacher's limitations in empowering participants' awareness of differentiated environment because the design and learning patterns were still traditional based on low-level cognitive achievement. On the other hand, teachers are limited to participating in various activities to support the improvement of their performance and profession including information on developing issues related to the environment as well as competencies and skills in teaching students according to the needs of the times. This activity also aims to introduce teachers to ideal pedagogical competencies in line with the demands of globalization, especially in cultivating and training creative thinking skills about environmental issues for elementary education students
Migration to Viable Platform for Effective Library Operations: Millennium Experiences of Two Academic Libraries in Nigeria
The study assessed migration of digital content and provision of viable platform for effective library operations; the Millennium experiences of two academic libraries in Nigeria. This was with a view to providing valuable information for stakeholders to guide them in software subscription and development. The descriptive survey, method was adopted for the study. eighteen librarians/ 5 para-librarians from Covenant University and 20 Librarians/ 8 para-librarians from University of Lagos constitute the target population. The purposive sampling technique was adopted. Instruments of data collection were interview, focus group discussion (FGD) and Questionnaire. The study revealed that migration experience to Millenium software was not so smooth and easy. Respondents preferred it however because it is web-based and has wide range of operations and upgrade options to suit any emerging demand in the future etc. The challenges faced by the librarians include: Subscription to individual right to access (pot) in Millenium, vendor/host controlled actual content with Millenium, absence of in-depth feasibility study and testing the product before embarking on the migration exercise. The study recommended that subscription to any software should not be based on individual pot or module as with Millenium software but be open and integrated among other
Reproductive biology of Chela fasciata Silas – an endemic ornamental barb of the of Western Ghats of India
Reproductive biology of Chela fasciata, an ornamental cyprinid fish endemic to the Western Ghats of Kerala, was studied from144 specimens (94 females and 50 males) ranging in size from 26.0 to 82.0 mm. The ovaries showed asynchronous oocyte development. The first mature female appeared at 40–45 mm total length (TL) and male at 25–30 mm TL. The size at first maturity estimated was 45.75 and 36.25 mm for females and males respectively. All females were mature at 60 mm TL and males at 45 mm TL. C. fasciata was found to be a multiple spawner with a protracted spawning season; the individuals spawn intermittently. Absolute fecundity ranged from 2669 to 4437 in fishes of size range 49.5 to 82 mm TL. The number and size of eggs were found to be directly proportional to the size and age of the fish. Fecundity showed a positive linear relationship (p<0.05) with the length and weight of both the fish and ovary
Studies on the Inhibitory Effect of Various Phytochemical Components on 3- Hydroxy 3- Methyl Glutaryl (HMG) CoA Reductase in Cholesterol Biosynthesis
Hyperlipidemia is a condition which is characterized by abnormal
elevation of lipids (triglyceride and cholesterol) and lipoproteins (LDL,
VLDL) levels in the blood. [1] It is also the major risk factor in the
initiation and progression of the atherosclerotic lesions. Evidence suggests
that the progression can be slowed if elevated serum concentration of the
atherogenic lipoprotein and triglycerides are reduced, thereby preventing
coronary heart disease. [2] Statins, a class of cholesterol lowering drugs that
inhibits cholesterol synthesis, have been most widely prescribed for
treating hypercholesterolemia and reducing cholesterol levels through
therapeutic drugs as statins have significantly reduced the risk of the
development of atherosclerosis and associated cardiovascular diseases.
Objectives:
1. To collect, identify and to prepare the aqueous extract of the
plant/plant parts.
2. To conduct the in vivo study by inducing the lipid levels of the
animals by feeding them with the hyperlipidemic diet and
treating with the drugs.
3. To monitor the body weight and food intake of the animals
throughout the study.
4. To estimate the level of Total Cholesterol, Triglycerides,
HDL, VLDL and LDL in serum and hepatic tissue.
5. To determine the atherogenic index and percentage of
protection by the drugs in serum and in hepatic tissue.
6. To assay the level of Lipid Peroxidation, Catalase (CAT),
Superoxide Dismutase (SOD), Vitamin E and Vitamin C in
plasma, hemolysate and hepatic tissue.
7. To assay the level of Aspartate Transaminase (AST), Lactate
Dehydrogenase (LDH), Creatinine Kinase (CK-MB) to
monitor the tissue damage and to estimate the level of
Glucose in blood.
8. To assess the activity of HMG CoA reductase by determining
the rate of oxidation of NADPH in the hepatocytes.
9. To screen the histopathological changes in the tissues.
10. To identify the major secondary metabolites present in the test
drug by analyzing the plant extract in Gas Chromatography-
Mass Spectrometer (GCMS).
11. Elucidation of the mode of interaction of these secondary
metabolites with their target using in silico molecular docking
studies.
Considering the results of the present study it may be concluded
that the aqueous extracts of decholestrate and phytoformulation 1 exhibit
possible protective mechanism against the development of coronary heart
disease. It also prevents hyperlipidemic complications due to lipid
peroxidation and failure in antioxidant systems. Further the GC-MS and
the molecular docking studies were helpful in isolation, identification and
characterisation of the active secondary molecules that were involved in
the inhibition of the enzyme receptor proving its antihyperlipidemic
potential
Novologues Containing a Benzamide Side Chain Manifest Anti-proliferative Activity Against Two Breast Cancer Cell Lines
The heat shock protein 90 (Hsp90) folding machinery is essential for the maturation of nascent polypeptides into their biologically active three-dimensional-structures and for the rematuration/clearance of misfolded proteins that form under cellular stress.1–3 As a prosurvival chaperone, Hsp90 overexpression is commonly observed in transformed cells, which is required to sustain the hostile tumor micro-environment associated with nutrient deprivation and hypoxia. Pharmacological inhibition of Hsp90 has been shown to induce the degradation of oncogenic proteins associated with all six hallmarks of cancer that rely upon Hsp90.4–8 Consequently, Hsp90 represents a highly sought after target for the treatment of cancer. In fact, 17 small molecules that bind competitively to the N-terminal ATP-binding pocket are under clinical evaluation against various cancers.9,10 However, heat shock factor 1 (HSF-1), the master regulator of the pro-survival heat shock response also binds Hsp90. Ultimately, Hsp90 N-terminal inhibition results in HSF-1 release, and upon phosphorylation, trimerizes and translocates to the nucleus wherein it binds the heat shock elements to activate the pro-survival, heat shock response (HSR). The HSR serves to expand the cellular buffering capacity and to assist in the maturation of mutated and oncogenic substrates.11 This concomitant heat shock response is detrimental to the treatment of cancer and may lead to drug resistance and tumor metastasis.12 Recent studies have demonstrated that allosteric modulation of the Hsp90 C-terminus can separate the pro-survival heat shock response from pro-apoptotic, client protein degradation.13–20 Two classes of small molecules derived from novobiocin 1, (Figure 1) the first identified Hsp90 C-terminal inhibitor, were discovered via the structure-activity relationship studies. KU-32 (2), which lacks a 4-hydroxyl, the 3’-carbamate, and contains an acetamide in lieu of a prenylated benzamide, represents a lead compound that induces the heat shock response at concentrations much lower than that needed for client protein degradation.2,21 Consequently, this class of analogues has been evaluated as neuroprotective agents to refold protein aggregates.22–24 In contrast, KU-174 (3) contains a biarylamide side chain in lieu of the acetamide, and induces Hsp90 client protein degradation without induction of the heat shock response.25–26 Therefore, this class of novobiocin analogues manifests optimal properties for the treatment of cancer, as no HSR is observed with such compounds
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