Oculometer for remote tracking of eye movement

Prototype oculometer which tracks lateral eye position and measures the direction of the eyes optical axis, pupil size, and blink occurrence performs measurements on the subject on a real-time basis from a remote location

System design study for an optimal remote oculometer for use in operational aircraft

System design of optimal remote oculometer for use in operational aircraf

Design of a breadboard remote oculometer

Design and fabrication of moving mirror subsystem and optics required for breadboard remote oculomete

Energy transfer in nonlinear network models of proteins

We investigate how nonlinearity and topological disorder affect the energy relaxation of local kicks in coarse-grained network models of proteins. We find that nonlinearity promotes long-range, coherent transfer of substantial energy to specific, functional sites, while depressing transfer to generic locations. Remarkably, transfer can be mediated by the self-localization of discrete breathers at distant locations from the kick, acting as efficient energy-accumulating centers.Comment: 4 pages, 3 figure

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer

Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [18F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy. Results: Breast tumour SUVmax of [18F]ICMT-11 was low at baseline and unchanged following therapy. Measurement of M30/M60 cytokeratin-18 cleavage products showed that therapy was predominantly not apoptosis in nature. While increases in caspase-3 staining on breast histology were seen, post-treatment caspase-3 positivity values were only approximately 1%; this low level of caspase-3 could have limited sensitive detection by [18F]ICMT-11-PET. Fourteen out of 15 breast cancer patients responded to first–line chemotherapy (complete or partial response); one patient had stable disease. Four patients showed increases in regions of high tumour [18F]ICMT-11 intensity on voxel-wise analysis of tumour data (classed as PADS); response was not exclusive to patients with this phenotype. In patients with lung cancer, multi-parametric [18F]ICMT-11 PET and MRI (diffusion-weighted- and dynamic contrast enhanced-MRI) showed that PET changes were concordant with cell death in the absence of significant perfusion changes. Conclusion: This study highlights the potential use of [18F]ICMT-11 PET as a promising candidate for non-invasive imaging of caspase3/7 activation, and the difficulties encountered in assessing early-treatment responses. We summarize that tumour response could occur in the absence of predominant chemotherapy-induced caspase-3/7 activation measured non-invasively across entire tumour lesions in patients with breast and lung cancer

Beryllium in the Ultra-Lithium-Deficient,Metal-Poor Halo Dwarf, G186-26

The vast majority of low-metal halo dwarfs show a similar amount of Li; this has been attributed to the Li that was produced in the Big Bang. However, there are nine known halo stars with T $>$ 5900 K and [Fe/H] $<$ $-$1.0 that are ultra-Li-deficient. We have looked for Be in the very low metallicity star, G 186-26 at [Fe/H] = $-$2.71, which is one of the ultra-Li-deficient stars. This star is also ultra-Be deficient. Relative to Be in the Li-normal stars at [Fe/H] = $-$2.7, G 182-26 is down in Be by more than 0.8 dex. Of two potential causes for the Li-deficiency -- mass-transfer in a pre-blue straggler or extra rotationally-induced mixing in a star that was initially a very rapid rotator -- the absence of Be favors the blue-straggler hypothesis, but the rotation model cannot be ruled-out completely.Comment: Accepted for Ap.J. Letters 10 pages, 4 figure

Prescription pattern of benzodiazepines for inpatients at a tertiary care university hospital in Pakistan

Objective: To determine the point prevalence of benzodiazepine prescriptions for inpatients at a tertiary care university hospital in Pakistan and to correlate it with prescription patterns of various specialties, indications and demographic variables of the patients.Methods: This 24-hours point prevalence study was done at The Aga Khan University Hospital, Karachi. By convenient random sampling, 208 inpatients were interviewed. Patients\u27 files were also studied to record the drugs administered. Data was entered into questionnaires and analyzed by SPSS 10.0.Results: The point prevalence of the benzodiazepines was 21.2%. It was higher among males than females and among surgical than non-surgical patients. Midazolam was the most commonly used benzodiazepine, followed by Alprazolam and Lorazepam. Pre-anesthesia and psychiatric symptoms were the two most common indications. Oral route was used in 84% patients for drug administration and mean Valium equivalent dosage was 4.86 mg/day. Mean length of prescription was 3 days. Longer duration of hospitalization was a significant predictor of the requirement of benzodiazepine prescription (p-value = 0.020).CONCLUSION: Prescription pattern of benzodiazepines at a tertiary care university hospital is similar to that reported in the developed countries through monitoring at various levels by physicians, clinical pharmacist and nursing staff. Data regarding the prescription pattern of benzodiazepines is scarce, and it needs to be expanded to formulate clear guidelines regarding their prescription

Universal transport in 2D granular superconductors

The transport properties of quench condensed granular superconductors are presented and analyzed. These systems exhibit transitions from insulating to superconducting behavior as a function of inter-grain spacing. Superconductivity is characterized by broad transitions in which the resistance drops exponentially with reducing temperature. The slope of the log R versus T curves turns out to be universaly dependent on the normal state film resistance for all measured granular systems. It does not depend on the material, critical temperature, geometry, or experimental set-up. We discuss possible physical scenarios to explain these findings.Comment: 4 pages, 3 figure