Summary of the TCI findings in BD and healthy controls from previous studies. We present only the TCI traits that we have found to be significantly different in bipolar patients and healthy controls.

<p>N: number of individuals.</p><p>HA: Harm Avoidance. P: Persistence. SD: Self-Directedness. C: Cooperativeness. ST: Self-Transcendence.</p><p>BP I: bipolar I patients. BP II: bipolar II patients. BP: BP I+BP II.</p><p><b>+</b> Higher in patients than in controls.</p><p><b>−</b> Lower in patients than in controls.</p><p>n.s. non significant difference between patients and controls. n.m. not measured.</p>*<p>Other diagnostic groups were studied in addition to bipolar patients.</p><p>HRSD Hamilton’s Rating Scale for Depression.</p><p>MADRS Montgomery-Åsberg Depression Rating Scale.</p><p>YMRS Young’s Mania Rating Scale.</p><p>UR = unaffected relatives.</p

Multivariate analysis of the influence of the COMT genotype on TCI traits in bipolar patients.

<p>The table shows the mean values and the 95% confidence intervals for the TCI dimensions in which there were statistically significant effects of COMT genotype.</p><p>NS: Novelty seeking. The values of the Met/Met genotype are greater than the Val/Val genotype.</p><p>SD: Self-Directedness. The values of the Met/Met genotype are lower than the Val/Met genotype.</p><p>C: Cooperativeness. The values of the Val/Val genotype are lower than the Val/Met genotype.</p

Description of the groups of patients and controls.

<p>N: number of individuals.</p><p>One DNA sample was lost.</p

TCI scores (mean ± sd) of patients and controls.

<p>N = number of individuals.</p><p>t = Student’s t test.</p><p>W = Mann-Whitney test.</p>*<p>denotes a significant difference between patients and controls.</p